Gallenblasenpolypen: Prävalenz und Risikofaktoren

Kratzer, Wolfgang; Schmid, A; Akinli, A. S.; Thiel, R van; Mason, Richard; Schüler, Andreas; Haenle, Mark Martin

doi:10.1055/s-0029-1245265

Cited by 17 publications

(11 citation statements)

References 23 publications

(73 reference statements)

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“…The current study also confirmed a prevalence (6.9%) of gallbladder polyps in the Chinese population lower than that previously reported in Taiwan (9.5%), 4 but higher than those reported in Danish (4.3%), 26 Japanese (5.6%) 27,28 and German (6.1%) 15 populations. This study demonstrated a higher prevalence of gallbladder polyps in male than in female subjects in all age groups (except in people aged >70 years), which is consistent with findings in some studies, 5,14,29,30 but contrary to those in others 31,32 .…”

Section: Discussionsupporting

confidence: 91%

“…Many previous studies have shown that the risk factors associated with biliary stones are age, race, gender, obesity and diabetes mellitus; and that those associated with gallbladder polyps are age, gender, body mass index (BMI), HBV infection and diabetes mellitus 4,5,14–16 . However, in China, prevalences of biliary stones and gallbladder polyps are seldom reported and the risk factors for these conditions are incompletely defined, 2,4,14,17 especially in terms of associations between hyperlipidaemia, TGW and hepatitis B status, and gallbladder polyps.…”

Section: Introductionmentioning

confidence: 99%

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Prevalences of and risk factors for biliary stones and gallbladder polyps in a large Chinese population

Luan

et al. 2012

HPB

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Objectives: This study aimed to identify the prevalences of and risk factors associated with the development of gallbladder stones and polyps in a large Chinese population. Methods: Prevalences of and risk factors for biliary stones and gallbladder polyps were retrospectively investigated among subjects who underwent a general check‐up at the Health Screening Centres of Peking Union Medical College Hospital and Beijing Charity Hospital between January 2007 and June 2010. Results: A total of 60 064 people were enrolled in the study. Overall prevalences of biliary stones and gallbladder polyps were 4.2% (n= 2527) and 6.9% (n= 4119), respectively. Risk factors associated with increased odds ratios (ORs) for the development of biliary stones were female gender (OR = 1.51), age ≥50 years (OR = 2.09), history of hypertension (OR = 1.37), thickened gallbladder wall (cholecystitis) (OR = 1.98), fasting blood glucose ≥6.10 mmol/l (OR = 1.27), body mass index ≥25 kg/m2 (OR = 1.25), systolic blood pressure ≥140 mmHg (OR = 1.31) and diastolic blood pressure ≥90 mmHg (OR = 1.44). Factors associated with gallbladder polyps were female gender (OR = 0.66), thickened gallbladder wall (OR = 2.09), negativity for hepatitis B surface antigen (HBsAg) and positivity for hepatitis B core antibody (anti‐HBc) (OR = 2.61), and positivity for both HBsAg and anti‐HBc (OR = 3.21). Conclusions: Prevalences of biliary stones and gallbladder polyps among Chinese people are similar to those reported for other populations. Biliary stones appear to be associated with female gender, age, obesity, blood glucose, blood pressure and cholecystitis. Male gender, hepatitis B virus infection and cholecystitis were strong risk factors for the formation of gallbladder polyps.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Prevalences of and risk factors for biliary stones and gallbladder polyps in a large Chinese population

Luan

et al. 2012

HPB

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“…The prevalence of GBPs ranges from 1.0-6.9% in the West [3]. GBPs have been reported to have prevalences of 1.4 and 6.1% in Germany [4,5]. Zheng et al [6] reported that the incidence of GBPs was 7.3% in a large Chinese population.…”

Section: Introductionmentioning

confidence: 99%

Association between the non-HDL-cholesterol-to-HDL-cholesterol ratio and the risk of gallbladder polyp formation among men: a retrospective cohort study

et al. 2020

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Background: Dyslipidaemia and male sex are associated with gallbladder polyp (GBP) formation. However, the potential relation between the non-high-density lipoprotein-cholesterol-to-high-density lipoprotein-cholesterol (non-HDL-c/HDL-c) ratio and GBPs in men is unclear. Methods: A total of 1866 eligible subjects were selected for this retrospective cohort study from Wuhan Union Hospital between April 1, 2013, and November 30, 2014. Clinical and laboratory data of subjects were collected. Patients with GBPs or cholecystectomy at baseline, with missing data for baseline lipid profiles, following abdominal ultrasonography or taking lipid-lowering drugs were excluded. The patients were divided into five groups based on their non-HDL-c/HDL-c ratios, and descriptive analyses of the baseline data were performed. A Cox proportional hazards model was applied to estimate the relationship between the non-HDL-c/HDL-c ratio and GBPs. Results: After a median follow-up of 1 year, 7.34% (n = 137) of the subjects developed GBPs. Compared with subjects without GBPs, those who developed GBPs after follow-up had significantly higher triglyceride (TG) levels and non-HDL-c/HDL-c ratios. The prevalence of GBPs showed a linearity increment with age, peaked in the 30-39 years group, 40-49 years group and 50-59 years group, and then declined slightly. The results of univariate analysis showed that the non-HDL-c/HDL-c ratio (hazard ratio (HR) = 1.29, 95% confidence interval (CI), 1.05-1.60, P = 0.0159) was positively correlated with GBPs. In the fully adjusted Cox regression model, the HRs were 2.24 for quintile 2 (95% CI: 1.13-4.44, P = 0.0203), 1.50 for quintile 3 (95% CI: 0.73-3.10, P = 0.269), 2.52 for quintile 4 (95% CI: 1.26-5.01, P = 0.0087) and 2.13 for quintile 5 (95% CI: 1.04-4.37, P = 0.0397). No interaction was found among the subgroups. Conclusions: A higher non-HDL-c/HDL-c ratio is independently related to a higher risk of GBP formation in Chinese men. Further research is needed to investigate whether this association exists in different regions and races.

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“…Patients in the cholesterol polyp group were older compared with the non-polyp group (48.28 ± 12.81 vs. 40.9 ± 13.85, respectively, P < 0.001), 21.00 (7.00), P < 0.001]. FPG, hypertension, and TG were not significantly different between the two groups ( Table 1).…”

Section: Univariate Analysis Of Cholesterol Polyp Formationmentioning

confidence: 92%

Risk factors for cholesterol polyp formation in the gallbladder are closely related to lipid metabolism

Yang

Bai

et al. 2021

Lipids Health Dis

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Background The purpose of this study was to assess the risk factors for cholesterol polyp formation in the gallbladder. Methods This was a multicenter retrospective study based on pathology. From January 2016 to December 2019, patients who underwent cholecystectomy and non-polyp participants confirmed by continuous ultrasound follow-ups were reviewed. Patients in the cholesterol polyp group were recruited from three high-volume centers with a diagnosis of pathologically confirmed cholesterol polyps larger than 10 mm. Population characteristics and medical data were collected within 24 h of admission before surgery. The non-polyp group included participants from the hospital physical examination center database. They had at least two ultrasound examinations with an interval longer than 180 days. Data from the final follow-up of the non-polyp group were analyzed. The risk factors for cholesterol polyp formation were analyzed by comparing the two groups. Results A total of 4714 participants were recruited, including 376 cholesterol polyp patients and 4338 non-polyp participants. In univariate analysis, clinical risk factors for cholesterol polyps were age, male sex, higher body mass index (BMI), higher low-density lipoprotein (LDL), lower high-density lipoprotein (HDL), and higher aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. In multivariate logistic analysis, independent risk factors were age > 50 years (odds ratio [OR] = 3.02, 95% confidence interval [CI] 2.33–3.91, P < 0.001], LDL > 2.89 mmol/L (OR = 1.38, 95% CI 1.08–1.78, P = 0.011), lower HDL (OR = 1.78 95% CI 1.32–2.44, P < 0.001), AST > 40 IU/L (OR = 3.55, 95% CI 2.07–6.07, P < 0.001), and BMI > 25 kg/m 2 (OR = 1.32, 95% CI 1.01–1.72, P = 0.037). Conclusions Age, LDL, HDL, AST, and BMI are strong risk factors for cholesterol polyp formation. Older overweight patients with polyps, accompanied by abnormal lipid levels, are at high risk for cholesterol polyps.

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Gallenblasenpolypen: Prävalenz und Risikofaktoren

Cited by 17 publications

References 23 publications

Prevalences of and risk factors for biliary stones and gallbladder polyps in a large Chinese population

Prevalences of and risk factors for biliary stones and gallbladder polyps in a large Chinese population

Association between the non-HDL-cholesterol-to-HDL-cholesterol ratio and the risk of gallbladder polyp formation among men: a retrospective cohort study

Risk factors for cholesterol polyp formation in the gallbladder are closely related to lipid metabolism

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