Gallbladder Sludge and Lithiasis in an Infant Born to a Morphine User Mother

Figueroa-Colón, Reinaldo; Tolaymat, Naser; Kao, Simon C.

doi:10.1097/00005176-199002000-00015

Cited by 9 publications

(4 citation statements)

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“…Radiologists use this action of morphine to augment radionuclide cholescintigraphy for identification of cholecystitis and ductal obstruction 59–62 . Morphine‐induced failure of the SO to relax is likely to be one of the factors involved in the biliary stasis and cholelithiasis associated with chronic administration of morphine in animals 63 and humans 64 …”

Section: Opiatesmentioning

confidence: 99%

“…[59][60][61][62] Morphine-induced failure of the SO to relax is likely to be one of the factors involved in the biliary stasis and cholelithiasis associated with chronic administration of morphine in animals 63 and humans. 64 Like other sphincters, activation of the inhibitory innervation of the SO relaxes myogenic tone and opens the sphincter. The probable explanation for the action of morphine and presumably opioid peptides to inhibit opening of the SO is suppression of excitability in inhibitory motor neurones to the sphincteric musculature.…”

Section: Opiatesmentioning

confidence: 99%

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Function of opioids in the enteric nervous system

Wood

Galligan

2004

Neurogastroenterology Motil

319

300

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Alterations in gastrointestinal motility and secretion underlie the constipating action of therapeutically administered opiates. The prototype opiate is morphine, which acts to delay gastric emptying and intestinal transit, to suppress intestinal secretion of water and electrolytes and to suppress transport of bile into the duodenum. The effects of opiates, synthetic opioids and endogenously released opioid peptides on these organ-level gastrointestinal functions reflect actions on electrical and synaptic behaviour of neurones in the enteric nervous system. Adverse effects and positive therapeutic effects of administration of opioid-receptor-blocking drugs on the digestive tract must be understood in the context of the neurophysiology of the enteric nervous system and mechanisms of neural control of gastrointestinal smooth muscle, secretory glands and blood-lymphatic vasculature. We review here the integrated systems of physiology and cellular neurobiology that are basic to understanding the actions of opioid agonists and antagonists in the digestive tract.

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Section: Opiatesmentioning

confidence: 99%

Section: Opiatesmentioning

confidence: 99%

Function of opioids in the enteric nervous system

Wood

Galligan

2004

Neurogastroenterology Motil

319

300

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“…There are few studies that have investigated the effects of morphine on the biliary system. In one study, gallbladder stone formation in mothers addicted to morphine was reported (17). In a study conducted by Zsigmond et al, the injection of morphine significantly reduced the diameter of the bile duct (18).…”

Section: Discussionmentioning

confidence: 99%

Effect of Fentanyl and Morphine on Gallbladder Dimensions in Newborns Admitted to the Neonatal Intensive Care Unit: A Randomized Double-Blinded Clinical Trial

Naderi

Goodarzi

Naziri³

et al. 2017

Iran J Pediatr

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Background: The effect of fentanyl and morphine, two most frequently used drugs for premedication in general anesthesia, on gallbladder of newborns, has not been sufficiently investigated. Intubation and mechanical ventilation in a neonatal respiratory distress syndrome are stressful procedures, in which these two drugs are used to reduce stress and pain. We studied the effect of these drugs on neonatal bile system during these procedures

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“…Symptomatic gallstone disease is uncommon in infants (1‐7) and children before puberty (8‐13). In recent years, an increase in the frequency of gallstones in the very young age group has been reported (14,15).…”

mentioning

confidence: 99%

Characteristics of Gallbladder Bile of Infants and Children

Halpern,

Vinograd,

Laufer

et al. 1996

J. pediatr. gastroenterol. nutr.

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SummaryIn the past, biliary lipids of infants and children were studied in duodenal aspirates. This study was performed on original bile aspirated from the gallbladder. The analysis of lipids in bile demonstrated a significantly lower total lipid content in the bile of infants than in children (3.3 g/dl vs. 9.1 g/dl). The most prominent difference was demonstrated in the bile salt concentration (43.2 mM vs. 126.7 mM) and thereafter in the phospholipid content. Infants had a shorter nucleation time and a higher cholesterol saturation index than did children. These results may explain the increased tendency of infants to produce sludge and gallstones during total parenteral nutrition.

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Gallbladder Sludge and Lithiasis in an Infant Born to a Morphine User Mother

Cited by 9 publications

References 0 publications

Function of opioids in the enteric nervous system

Function of opioids in the enteric nervous system

Effect of Fentanyl and Morphine on Gallbladder Dimensions in Newborns Admitted to the Neonatal Intensive Care Unit: A Randomized Double-Blinded Clinical Trial

Characteristics of Gallbladder Bile of Infants and Children

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