Gallbladder Sarcoma: A Clinicopathological Study of Seven Cases from the UK and Austria with Emphasis on Morphological Subtypes

Husain, Ehab; Prescott, R.; Haider, Syeda Asma; Al-Mahmoud, R. W. T.; Zelger, Bernhard; Al-Daraji, Wael I.

doi:10.1007/s10620-008-0358-z

Cited by 19 publications

(32 citation statements)

References 26 publications

(23 reference statements)

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“…PGBS is most commonly seen in the seventh decade of life as gallbladder cancer, and its diagnosis is mostly based on postoperative specimen reports revealing its immunohistochemical and morphological features. The disease mainly occurs in older female adults two times higher than in men with symptoms of acute cholecystitis , and it has overall poor prognosis (1)(2)(3) . The symptoms and signs of gallbladder sarcomas are nonspecific.…”

Section: Discussionmentioning

confidence: 99%

“…The symptoms and signs of gallbladder sarcomas are nonspecific. Clinically most of the patients present with right upper quadrant pain with or without jaundice, loss of appetite, palpable mass, hyperbilirubinemia, weight loss, vomiting, pruritis, symptoms of acute and chronic cholecystitis, and elevated alkaline phosphatase levels (1,2) .…”

Section: Discussionmentioning

confidence: 99%

“…Risk factors and pathogenesis of PGBS is poorly understood. Mostly abnormal bile composition that causes stones, cholelithiasis with accompanying cholecystitis is blamed Irritation and chronic inflammatory changes have been suggested as promoting factors in the pathogenesis of PGBS (2)(3)(4) .…”

Section: Discussionmentioning

confidence: 99%

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Primary Gallbladder Pleomorphic Sarcoma: A Rare Case

Atıcı¹,

Demır²,

Yeşilkurt³

et al. 2019

TERH

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Primary gallbladder pleomorphic sarcoma is a very rarely seen type of tumor and its prognosis is not well known mainly due to the limited number of cases reported. Here, we present a case with primary gallbladder pleomorphic sarcoma of which diagnosis was based on morphology and immunohistochemistry. A 70-year-old male presented with three months of abdominal pain in the upper right quadrant and weight loss. The patient reported a past medical history of chronic cholecystitis. Using abdominal magnetic resonance imaging (MRI), the patient was diagnosed with gallbladder cancer. Radical cholecystectomy, with segment 4b and 5 resection of the underlying liver tissue and dissection of the pericholedochal lymph nodes were performed. Patient's postoperative course was unremarkable and he was discharged on the postoperative 5 th day. The immunohistochemical analyses supported the diagnosis of primary gallbladder pleomorphic sarcoma. The patient was referred to the department medical oncology for adjuvant chemotherapy Primary gallbladder pleomorphic sarcoma is a very rare histological type with an unclear pathogenesis. A better understanding of pathogenesis and treatment for this disease, with the larger case series may be better addressed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary Gallbladder Pleomorphic Sarcoma: A Rare Case

Atıcı¹,

Demır²,

Yeşilkurt³

et al. 2019

TERH

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“…A variety of tumor types have been described including leiomyosarcoma, rhabdomyosarcoma, angiomyosarcoma, Kaposi's sarcoma, malignant fibrous histiyocytoma, and synovial sarcoma [2]. Leiomyosarcoma of the gallbladder is an especially rare malignant tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Adenomatous hyperplasia of gallbladder is the most common benign mesenchymal proliferation, accounting for more than 40% of tumor-like lesions of the organ [1,2]. The malignant degeneration of adenomatous hyperplasia is rare.…”

Section: Introductionmentioning

confidence: 99%

Primary leiomyosarcoma of gallbladder

et al. 2012

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Malignant mesenchymalneoplasms of the gallbladder are extremely rare with only 105 cases of primary gallbladder sarcoma having been described. It has a very aggressive behavior and is usually diagnosed at advanced stages. Therefore, curative surgical management may not be possible. We performed a radical cholecystectomy (S4b + S5 segmentectomy), omentectomy and small bowel resection in a 54-year-old patient with locally invasive leiomyosarcoma of the gallbladder. Further studies are needed to confirm the benefit of aggressive treatment for patients with leiomyosarcoma of the gallbladder.

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