Gallbladder Paraganglioma: Report of a Rare Case

Öztaş, Muharrem; Ersöz, Nail; Özerhan, İsmail Hakkı; guler, armagan; Ünlü, Aytekin; Can, Mehmet Fatih; Peker, Yusuf

doi:10.5455/gulhane.22140

Cited by 3 publications

(2 citation statements)

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“…One case had manifested with gastrointestinal bleeding. 4 In our case, the asymptomatic gallbladder mass was discovered incidentally on PET-CT images of the abdomen.…”

Section: Discussionmentioning

confidence: 57%

Case of the Very Rare Gallbladder Paraganglioma

Shukla

Kashikar

Shraddha

et al. 2021

Indian J Radiol Imaging

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Gallbladder paraganglioma is a very rare condition, and only a few cases have been reported in the literature. Herein, we present and discuss the clinical and radiological findings of a 72-year-old woman who complained of heaviness, pain, and on and off watery discharge from the left ear for 1 year and reduced hearing in both ears. She was thoroughly investigated radiologically where multiple paragangliomas were found with the discovery of the very rare gallbladder paraganglioma. There is a need to realize the importance of thorough radiological evaluation in cases of head and neck paraganglioma to look for more such lesions in the body for early identification of patients with familial paraganglioma syndromes. With this practice, gene mutation carriers can be identified early in the course of their disease and brought to surgical attention before their disease becomes extensive and potentially life-threatening.

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“…One case had manifested with gastrointestinal bleeding. 4 In our case, the asymptomatic gallbladder mass was discovered incidentally on PET-CT images of the abdomen.…”

Section: Discussionmentioning

confidence: 57%

Case of the Very Rare Gallbladder Paraganglioma

Shukla

Kashikar

Shraddha

et al. 2021

Indian J Radiol Imaging

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“…Radiologically, paragangliomas do not exhibit any specific features on CT or magnetic resonance imaging (MRI). Extra-adrenal paragangliomas may show a similar appearance to a hemangioma on a CT due to its hypervascularity, and on T2-weighted MRI, it may exhibit a “salt and pepper” pattern over the regions with high and low signal intensities [ 20 , 21 ]. The case report by Mahin et al showed that gallbladder paraganglioma was intensively hyper-enhancing in the arterial phase on CT, raising concern for malignancy, which prompted cholecystectomy [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Gallbladder Paraganglioma: A Mysterious Histological Finding

Eun¹,

Harvey²,

Rana³

et al. 2023

Cureus

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Gallbladder paragangliomas are extremely rare with only a handful of cases reported so far. There are no definitive guidelines for the management of gallbladder paragangliomas due to their rarity. We present a case of a 53-year-old male who was found to have gallbladder paraganglioma post-laparoscopic cholecystectomy, performed for right upper abdominal pain. On review of the literature, all previously reported cases had been nonsecretory and benign. For patients who have no symptoms of secretory paragangliomas and no family history of endocrine syndromes, cholecystectomy and clinical follow-up may be a sufficient initial management following an incidental finding of gallbladder paraganglioma.

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Paraganglia of the Gallbladder: An Underrecognized Incidental Finding and Potential Diagnostic Pitfall

Ramlal

Voytek

Ligato

2020

Archives of Pathology &Amp; Laboratory Medicine

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Context.— The identification of paraganglia (PG) in the gallbladder (GB) is infrequent, and easily overlooked as it is not something routinely reported. Occasionally they may be misinterpreted as neoplastic cells, such as low-grade carcinomas, germ cell tumors, or because of their close resemblance to neuroendocrine cells, as low-grade neuroendocrine neoplasms. Objective.— To evaluate the incidence and histological features of PG of the GB in patients that underwent cholecystectomy, and discuss the potential misinterpretation of these benign structures as clusters of neoplastic cells. Design.— A retrospective study of cholecystectomy specimens performed over a 6-month period were reviewed for identification of PG. Immunohistochemical studies for chromogranin, synaptophysin, S100, and cytokeratin AE1/AE3 were performed in selected cases. Results.— A total of 365 GB were reviewed and in 16 cases (4.4%) PG was identified within the subserosal connective tissue of the GB wall or cystic duct adjacent to small capillaries, nerves, and ganglia. They consisted of well-demarcated, lobular structures ranging in size from 0.2 to 0.5 cm, which were predominantly composed of chief cells; with strong expression for chromogranin and synaptophysin and negative CKAE1/AE3, and a minor component of S100-positive sustentacular cells. Conclusions.— PG is an uncommon finding with a prevalence of 4.4% in our study. Awareness of their location, histologic features, and immunohistochemical profile may help practicing pathologists to confirm their benign nature, avoid a misdiagnosis of malignancy, and prevent unnecessary diagnostic work-up and treatment.

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Gallbladder Paraganglioma: Report of a Rare Case

Cited by 3 publications

References 0 publications

Case of the Very Rare Gallbladder Paraganglioma

Case of the Very Rare Gallbladder Paraganglioma

Gallbladder Paraganglioma: A Mysterious Histological Finding

Paraganglia of the Gallbladder: An Underrecognized Incidental Finding and Potential Diagnostic Pitfall

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