Gallbladder neuron count in cholelithiasis patients with and without Chagas disease

Crema, Eduardo; Ribeiro, Luís; Adad, Sheila Jorge; Ectchebehere, Renata Margarida; Júnior, Aiodair Martins; Silva, Alex Augusto

doi:10.1590/s0037-86822007000100003

Cited by 7 publications

(3 citation statements)

References 5 publications

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“…Gallbladder neuron counts in cholelithiasis in patients with Chagas disease have demonstrated a reduction in the number of neurons in the gallbladder wall 21. Given that the enteric excitatory motor neurons are damaged in Chagas disease, the prevalence of cholelithiasis, megagallbladder and megacholedochus is higher 74,75.…”

Section: Discussionmentioning

confidence: 99%

The Chronic Gastrointestinal Manifestations of Chagas Disease

Matsuda

Miller

Evora

2009

Clinics

139

117

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Chagas disease is an infectious disease caused by the protozoan Trypanosoma cruzi. The disease mainly affects the nervous system, digestive system and heart. The objective of this review is to revise the literature and summarize the main chronic gastrointestinal manifestations of Chagas disease. The chronic gastrointestinal manifestations of Chagas disease are mainly a result of enteric nervous system impairment caused by T. cruzi infection. The anatomical locations most commonly described to be affected by Chagas disease are salivary glands, esophagus, lower esophageal sphincter, stomach, small intestine, colon, gallbladder and biliary tree. Chagas disease has also been studied in association with Helicobacter pylori infection, interstitial cells of Cajal and the incidence of gastrointestinal cancer.

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Section: Discussionmentioning

confidence: 99%

The Chronic Gastrointestinal Manifestations of Chagas Disease

Matsuda

Miller

Evora

2009

Clinics

139

117

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“…Accordingly, megagallbladder could be part of other organomeglies in patients with Chagas' disease, and there is a well-known increased prevalence of gallstones among these patients. However, the studies on gallbladder function in Chagasic patients have reported both increased and increased gallbladder motility associated with the autonomic denervation that is a characteristic feature of the disease [33,34]. A higher FV has been described in diabetic patients, together with a similar impairment of the gallbladder motility, resulting in a higher prevalence of gallstones in diabetics [35].…”

Section: Discussionmentioning

confidence: 99%

Increased Prevalence of Gallstone Disease and Impaired Gallbladder Motility in Patients with Barrett’s Esophagus

et al. 2007

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The prevalence of gallstones in patients with Barrett's esophagus (BE) and their gallbladder motility relative to that of healthy volunteers and GERD patients without BE were investigated. Of the 707 patients reviewed, 203 (125 males and 78 females) had BE. The prevalence of gallstones was significantly higher in the patients with BE than in those without BE (34 vs. 20%, respectively). The gallbladder functions of 22 patients with GERD, 27 patients with BE and 21 healthy volunteers were assessed by ultrasonography before and after a test meal. The patients with BE had significantly higher fasting volume and residual volume, but lower ejection volume, ejection fraction and ejection rate values than those of the healthy controls. None of the ultrasonographic parameters of patients without BE were significantly different from those of the controls. Patients with BE have a more complex gastrointestinal motility disorder that involves the gallbladder, and this makes this subset of patients with GERD more prone to gallstone disease.

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“…A fascinating finding has been demonstrated upon histopathological examination of the gallbladder of patients with gastrointestinal involvement in chronic CD. A reduced neuronal count on the gallbladder wall has been shown when compared with healthy controls [218,219]. Additionally, the prevalence of cholelithiasis is increased in patients with CD, given the motility impairment of the gallbladder [220,221].…”

Section: Gallbladder and Biliary Tractmentioning

confidence: 99%

Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review

et al. 2021

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Chronic manifestations of Chagas disease present as disabling and life-threatening conditions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful research has outlined the different molecular mechanisms underlying Trypanosoma cruzi’s infection and the host-parasite interactions that follow, prompt diagnosis and treatment remain a challenge, particularly in developing countries and also in those where the disease is considered non-endemic. This review intends to present an up-to-date review of the parasite’s life cycle, genetic diversity, virulence factors, and infective mechanisms, as well as the epidemiology, clinical presentation, diagnosis, and treatment options of the main chronic complications of Chagas disease.

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Gallbladder neuron count in cholelithiasis patients with and without Chagas disease

Abstract: Various investigators agree that the incidence of cholelithiasis is greater in patients with

Cited by 7 publications

References 5 publications

The Chronic Gastrointestinal Manifestations of Chagas Disease

The Chronic Gastrointestinal Manifestations of Chagas Disease

Increased Prevalence of Gallstone Disease and Impaired Gallbladder Motility in Patients with Barrett’s Esophagus

Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review

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