Gallbladder Neuroendocrine Carcinoma: A Case Report with Radiological–Pathological Correlation

Abstract

Neuroendocrine tumors (NET) of the biliary system, specifically the gallbladder (GB), are extremely rare, accounting for only 0.2% of all NETs. The majority of GBNETs are discovered by chance during a histological examination of GB samples at autopsy, after cholecystectomy, or after surgery for other suspected biliary pathology. GBNETs are thought to develop from preexisting endocrine cells in the GB's neck or from induced endocrine cells caused by intestinal metaplasia of the body and fundus. We present a case of squamous cell carcinoma of the GB with neuroendocrine differentiation due to its rarity.

Neuroendocrine tumor of the gall bladder: A rare case report with review of literature

“…Furthermore, primary liver NETs and their metastases exhibit significant arterial enhancement, confirming their hypervascular nature and showing washout on venous or delayed phase [16] . Few GBNET case reports demonstrated hyperenhancement in the arterial phase and washout in venous/delayed phase [17] . This was consistent with our case which had hypervascularity and relative washout.…”