Gallbladder metastasis from renal cell carcinoma: A case report and literature review

Takagi, Kimiaki; Kawase, Kota; Minoshima, Kenichi; Yamaha, Masayoshi; Maekawa, Yuka; Yokoi, Shigeaki; Kusakabe, Mitsuhiko; Horie, Masanobu

doi:10.1016/j.eucr.2019.01.006

Cited by 12 publications

(12 citation statements)

References 5 publications

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“…On ultrasonography, the tumor often has a hyperechoic band on its surface because of its submucosal nature [4], though our present cases did not show such a clear hyperechoic band. In our present cases, color Doppler US and contrast-enhanced CT showed hypervascularity within the tumor, which may reflect the Fig.…”

Section: Discussioncontrasting

confidence: 74%

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Gallbladder metastasis of renal cell carcinoma presenting as a hypervascular polypoid lesion: case report of two cases with immunohistochemical analysis

et al. 2020

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Background: Metastasis of renal cell carcinoma (RCC) to the gallbladder is rare, and its clinicopathological feature remains poorly understood. We here present two cases of gallbladder metastasis from RCC presenting as a hypervascular polypoid lesion. Case presentation: The first case was a 73-year-old man who had undergone right nephrectomy for clear cell RCC. Imaging studies detected a hypervascular polypoid lesion in the gallbladder 6 years after nephrectomy. Laparoscopic cholecystectomy was done. The pathological findings of the polypoid lesion showed proliferation of clear cells in the submucosal layer. Immunohistochemically, the tumor was positive for carbonic anhydrase 9 (CA9) but negative for cytokeratin 7 (CK7), suggestive of metastatic RCC. The second case was a 43-year-old man who had undergone right nephrectomy for clear cell RCC. Imaging studies revealed a hypervascular polypoid lesion of 20 mm in diameter in the gallbladder 1 year after nephrectomy. The patient underwent expanded cholecystectomy and extra-hepatic bile duct resection with lymphadenectomy. Microscopically, the polypoid lesion of the gallbladder was composed of clear cells in the submucosal layer. Immunohistochemical analysis showed positive staining for epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA) but negative staining for CK7, leading to the diagnosis of metastatic RCC. Conclusions: Gallbladder metastasis from RCC is rare but should be considered when a hypervascular polypoid lesion in the gallbladder is detected during the follow-up period after RCC treatment.

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Section: Discussioncontrasting

confidence: 74%

“…During a median follow-up period of 10 months, 31 patients (67%) were alive and 6 patients (13%) died from metastatic disease. The presence or absence of metastasis to other organs might determine the survival time in these patients [3,4].…”

Section: Discussionmentioning

confidence: 99%

Gallbladder metastasis of renal cell carcinoma presenting as a hypervascular polypoid lesion: case report of two cases with immunohistochemical analysis

et al. 2020

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“…4 Among the cases of gallbladder metastasis, acute cholecystitis as a clinical presentation is thought to be associated with a poor prognosis and solitary metastasis is associated with favourable prognosis. 8 Recent studies in medical oncology demonstrated the efficacy of targeted therapy over immunotherapy. Previously interferon therapy was given but it resulted in only a modest response without any survival benefit.…”

Section: Discussionmentioning

confidence: 99%

Gallbladder metastasis from primary renal malignancy: case report and review

Harsha

Ali²,

Singh³

et al. 2022

Int Surg J

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Gallbladder metastases are rare, that too from a renal malignancy are further rare. Renal cell carcinoma (RCC) accounts for 3% of adult malignancies and >30% of cases are already metastatic by the time of presentation. Neither gallbladder is a usual site for RCC to metastasize nor is clear cell RCC common in gallbladder secondaries. We report one such case of a 50-year-old man who was incidentally diagnosed to have left sided renal cell carcinoma and developed gallbladder and lung metastases detected in follow-up imaging. Patient underwent radical nephrectomy followed by extended cholecystectomy later on. And presently is receiving targeted therapy for pulmonary metastases.

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“…Gastric cancer was the most common primary tumor metastasizing to the GB, followed by RCC, HCC, and colorectal cancer ( 9 10 ). Considering that RCC increases globally, with incidentally detected lesions during imaging studies, the prevalence of GB metastasis from this tumor may well reflect the incidence of these primary tumors.…”

Section: Discussionmentioning

confidence: 99%