Gallbladder Metastasis from Renal Cell Carcinoma: A Case Report with Review of the Literature

Ueda, Issei; Aoki, Takatoshi; H, Oki; Takahashi, Hiroyuki; Hayashida, Yoshiko; Minagawa, Nozomi; Yamaguchi, Koji; Fujimoto, Naohiro; Matsumoto, Tetsuro; Yamada, Shin‐ichi; Korogi, Yukunori

doi:10.2463/mrms.2013-0130

Cited by 21 publications

(27 citation statements)

References 21 publications

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“…In this study, we found most (91%) of the metastatic RCCs presented as a polypoid mass with narrow stalk, and 82% were hypervascular lesion by image studies. It has been observed that metastatic adenocarcinoma of the GB manifested as infiltrative and persistently enhancing wall thickenings, while the metastatic non-adenocarcinoma such as RCC usually manifested as a polypoid lesion in the gallbladder by computed tomography (CT) imaging study [3, 4, 14]. Some imaging studies with ultrasound, CT scan or MRI also showed a hypervascular polypoid mass like that of our case [4, 14].…”

Section: Discussionsupporting

confidence: 60%

“…It has been observed that metastatic adenocarcinoma of the GB manifested as infiltrative and persistently enhancing wall thickenings, while the metastatic non-adenocarcinoma such as RCC usually manifested as a polypoid lesion in the gallbladder by computed tomography (CT) imaging study [3, 4, 14]. Some imaging studies with ultrasound, CT scan or MRI also showed a hypervascular polypoid mass like that of our case [4, 14]. The metastatic polypoid mass showed high intensity on diffusion-weighted images, and the apparent diffusion coefficient was relatively low on MRI.…”

Section: Discussionmentioning

confidence: 99%

“…The metastatic polypoid mass showed high intensity on diffusion-weighted images, and the apparent diffusion coefficient was relatively low on MRI. These imaging findings are considered characteristic and may be helpful for preoperative diagnosis [4, 14]. Therefore, metastatic RCC should be taken into account for a gallbladder polyp with narrow hypervascular stalk, especially for those with the history of RCC.…”

Section: Discussionmentioning

confidence: 99%

“…Second, the reference lists of PubMed-selected metastatic RCC to gallbladder articles were screened systematically for additional studies of interest. A total of 35 related articles were selected for study [1–5, 7–9, 11, 12, 14–38]. …”

Section: Methodsmentioning

confidence: 99%

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Metastatic polyp of the gallbladder from renal cell carcinoma

et al. 2017

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BackgroundGallbladder metastasis from renal cell carcinoma (RCC) is extremely rare. The purpose of this study is to clarify the characteristics of metastatic RCC to gallbladder.MethodsThe pooled data for analysis were collected from the case of metastatic RCC to gallbladder encountered by our institution along with sporadic cases reported in literature from 1991 to 2015.ResultsA total of 50 cases of metastatic RCC to gallbladder were recruited for study. Fifty-seven percentage of the primary RCC was from the right kidney and 43% from the left. The median interval between diagnoses of primary and metastatic RCC to gallbladder was 36 months, with the longest duration up to 324 months. Most (70%) were asymptomatic. The size of metastatic RCC to gallbladder ranged from 0.8 cm to 9 cm, with median of 2.6 cm. Majority (91%) of the metastatic RCCs presented as a polypoid mass with narrow stalk, and 82% were hypervascular lesion. The overall 1 year, 3 year and 5 year survival rate was 91.5%, 76.2% and 59.3% respectively, with a median of 26.5 months. Number of the metastatic site, timing of gallbladder metastasis, symptom, tumor size and operation type of cholecystectomy seemed to have no impact on survival.ConclusionsMetastatic RCC to the gallbladder should be taken into account for a gallbladder polypoid mass with narrow hypervascular stalk during the diagnosis and/or follow-up of primary RCC. Gallbladder metastasis from RCC is not necessarily to be an advanced stage with poor outcome, and cholecystectomy is recommended whenever possible.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Metastatic polyp of the gallbladder from renal cell carcinoma

et al. 2017

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“…Presentation is usually asymptomatic with lesions discovered on imaging or autopsy with an overall incidence of 0.6% [2]. Radiologically metastatic renal cell carcinoma to the gallbladder presents with hypervascular polypoid lesions on CT and US [3,4]. Recent studies specify a distinct MRI pattern with a low-intensity T1 signal, enhancement with gadolinium administration, and a low diffusion coefficient on a diffusion-weighted phase [3].…”

mentioning

confidence: 99%

Renal Cell Carcinoma Metastatic to the Gallbladder

Hazen

Deeken

Cocieru

2017

J Gastrointest Canc

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Metachronous gallbladder metastasis from renal cell carcinoma—a rare clinical manifestation

Mrak

Lackner

Mischinger

et al. 2016

Wien Klin Wochenschr

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Renal cell carcinoma (RCC) represents a rare tumor entity accounting for approximately 3 % of all malignancies in the adult population. Approximately 30 % of all patients suffering from RCC develop metastases after nephrectomy and another 30 % of patients suffer from synchronous metastases at the date of diagnosis. Gallbladder metastases represent an extremely rare clinical condition and up to date there are only 35 published cases of gallbladder metastasis from RCC. Surgical resection should be the treatment of choice in any case based on the reported data in literature. In spite of the small series of cases, survival can be improved even in patients suffering from additional sites of metastases.

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Gallbladder Metastasis from Renal Cell Carcinoma: A Case Report with Review of the Literature

Cited by 21 publications

References 21 publications

Metastatic polyp of the gallbladder from renal cell carcinoma

Metastatic polyp of the gallbladder from renal cell carcinoma

Renal Cell Carcinoma Metastatic to the Gallbladder

Metachronous gallbladder metastasis from renal cell carcinoma—a rare clinical manifestation

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