Gallbladder contractility: variation in normal subjects.

Donald, J. J.; Fache, J S; Buckley, Anne; Burhenne, H J

doi:10.2214/ajr.157.4.1892030

Cited by 23 publications

(26 citation statements)

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“…Radiologically the gallstone volume can be assessed using the ellipsoid formula. 24 While a cause and effect relationship cannot be substantiated with the present study, constant erosion of the gall bladder wall by gallstones over time may constitute a risk.…”

Section: 7-10contrasting

confidence: 54%

Correlation of gallstone characteristics with mucosal changes in gall bladder

Marie

Duhan²,

Singh³

et al. 2012

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Section: 7-10contrasting

confidence: 54%

Correlation of gallstone characteristics with mucosal changes in gall bladder

Marie

Duhan²,

Singh³

et al. 2012

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“…Pons et al [18] and Krishnamurthy et al [19] studied the reproducibility of GBEF by CCK CS on 44 subjects and 52 subjects respectively and found it reproducible with correlation coefficients of 0.439 and 0.73 respectively. On the other hand, Donald et al [16] studied gallbladder contractility in 30 healthy subjects by fatty meal ultrasonography and reported wide GBEF variability within each subject. However, their study focused on variability of GB volumes and GBEF values between and within the subjects.…”

Section: Discussionmentioning

confidence: 99%

Reproducibility of Gallbladder Ejection Fraction Measured by Fatty Meal Cholescintigraphy

Al-Muqbel

Hani

El-Heis

et al. 2010

Nucl Med Mol Imaging

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Purpose There are conflicting data in the literature regarding the reproducibility of the gallbladder ejection fraction (GBEF) measured by fatty meal cholescintigraphy (CS). We aimed to test the reproducibility of GBEF measured by fatty meal CS. Methods Thirty-five subjects (25 healthy volunteers and 10 patients with chronic abdominal pain) underwent fatty meal CS twice in order to measure GBEF1 and GBEF2. The healthy volunteers underwent a repeat scan within 1-13 months from the first scan. The patients underwent a repeat scan within 1-4 years from the first scan and were not found to have chronic acalculous cholecystitis (CAC). Our standard fatty meal was composed of a 60-g Snickers chocolate bar and 200 ml full-fat yogurt. Results The mean ± SD values for GBEF1 and GBEF2 were 52±17% and 52±16%, respectively. There was a direct linear correlation between the values of GBEF1 and GBEF2 for the subjects, with a correlation coefficient of 0.509 (p=0.002). Subgroup data analysis of the volunteer group showed that there was significant linear correlation between volunteer values of GBEF1 and GBEF2, with a correlation coefficient of 0.473 (p=0.017). Subgroup data analysis of the non-CAC patient group showed no significant correlation between patient values of GBEF1 and GBEF2, likely due to limited sample size. Conclusions This study showed that fatty meal CS is a reliable test in gallbladder motility evaluation and that GBEF measured by fatty meal CS is reproducible.

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“…Indeed, since gallstones are diagnosed mostly with US, it seems desirable to obtain as much information as possible with this procedure in order to assess the eligibility of patients for nonsurgical treatment. In particular, since a good gallbladder function seems to be a prerequisite for ESWL [3,4], the demonstration of impaired gallbladder emptying at US could help rule out this therapeutic option. In the present work, US determination of gallbladder emptying after ceruletide gave results comparable to OCG after fatty meal.…”

Section: Discussionmentioning

confidence: 99%

“…Since serial measurements are not easily affordable in clinical practice, a single measurement is generally performed at the presumed time of maximal contraction. However, a considerable degree of uncertainty exists, since some authors take such measurements 30 to 40 min after the meal [7; 9, 17], while others wait 45 to 60 min [3,9,12]. Such differences might depend on meal composition, but one should remember that meal-induced gallbladder contraction depends on several factors.…”

Section: Discussionmentioning

confidence: 99%

“…Impaired gallbladder motility is a contributing factor in the pathogenesis of gallstones [1,2] and can reduce the success of extracorporeal shock-wave lithotripsy (ESWL) [3,4]. While ultrasound (US) is presently the procedure of choice for the diagnosis of gallstones, oral cholecystography (OCG) with fatty meal remains the Correspondence to: M. Muraca standard test for the study of gallbladder function [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Ultrasonic evaluation of gallbladder emptying with ceruletide: comparison to oral cholecystography with fatty meal

et al. 1994

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Assessment of gallbladder function is required prior to nonsurgical treatment of gallstones. In order to develop a practical and reproducible method of evaluation, gallbladder emptying was studied by ultrasound (US) in 55 gallstone patients after intramuscular administration of ceruletide (0.3 micrograms/kg). In 27 of these subjects, the US procedure was compared to oral cholecystography (OCG) with fatty meal. Maximal percent gallbladder contraction was reached 30 min after ceruletide in all patients. Maximal percent contractions were 47.5 +/- 27.7 during US with ceruletide and 33.9 +/- 16.3 during OCG with fatty meal (p = 0.03). A significant linear relationship was found between the results obtained with the two different procedures (r = 0.57; p = 0.002). Serial US determinations of gallbladder emptying were performed in 16 patients. Individual variation was below 20% in 11 subjects, and in five subjects it ranged between 20 and 40%. Minor, self-limiting side effects were observed in 13 patients. US determination of gallbladder emptying after ceruletide appears to be a practical and reliable method to assess gallbladder function.

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Gallbladder contractility: variation in normal subjects.

Abstract: These data show that a wide variation exists within a normal person in the degree of gallbladder contraction exhibited from one day to another, and a single test for gallbladder contraction can be misleading.

Cited by 23 publications

References 0 publications

Correlation of gallstone characteristics with mucosal changes in gall bladder

Correlation of gallstone characteristics with mucosal changes in gall bladder

Reproducibility of Gallbladder Ejection Fraction Measured by Fatty Meal Cholescintigraphy

Ultrasonic evaluation of gallbladder emptying with ceruletide: comparison to oral cholecystography with fatty meal

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