Gallbladder Carcinoma Presenting With Elbow Swelling

Pande, Shantanu; Goyal, Devendra; Chowdhury, Zachariah; Dhal, Ipsita; Singh, Abhishek Kumar

doi:10.1097/rlu.0000000000003147

Cited by 1 publication

(1 citation statement)

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“…It is the most common malignant tumor in the biliary system, accounting for more than 70% of biliary malignancies. 88 , 89 Gemcitabine (GEM) is a chemotherapeutic agent for treating advanced metastatic cholangiocarcinoma and gallbladder cancer. However, GEM resistance is seen in many types of cancer.…”

Section: Anticancer Properties Of Maslinic Acidmentioning

confidence: 99%

The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review

Yu¹,

Xie²,

Cao³

et al. 2021

DDDT

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Cancer is still an insurmountable problem for humans and critically attacking human health. In recent years, natural products have gained increasing attention in the field of anti-tumor due to their extensive sources and minimal side effects. Maslinic acid (MA), a pentacyclic triterpene acid mainly derived from the olive tree (Olea europaea L.) has been confirmed to possess great anti-cancer effects. This paper reviewed the inhibitory effect of MA and its derivatives on lung cancer, colon cancer, ovarian cancer, gastric cancer, lymphatic, leukemia, breast cancer, pancreatic cancer, melanoma, prostate cancer, renal cell carcinoma, gallbladder cancer, and bladder cancer, among others. MA inhibited the proliferation of various tumor cells and showed lower IC 50 values in melanoma 518A2 cells and gastric cancer MKN28 cells compared with other cell lines. A series of semi-synthetic derivatives obtained by modifying MA chemical structure have been shown to have high cytotoxicity to human tumor cell lines, but low cytotoxicity to nonmalignant cells, which is conducive to developing its potential as a chemotherapeutic agent. These studies suggest that MA derivatives have broad prospects in the development of antitumor therapeutics in the future and warrant further study.

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Section: Anticancer Properties Of Maslinic Acidmentioning

confidence: 99%