Gallbladder Carcinoma in an Achondroplasia Boy

Abstract

Carcinoma of the gallbladder in an extremely rare tumor in childhood. We have found only five cases in the literature. Most of them were associated with an ethnic group - The Navajo Indians - who are known to have high incidence of gallbladder disease. We report here on the exceptional presence of this type of tumor in a child, who also had achondroplasia. This, as far as we can determine, is the first such case ever reported.

Management of Polypoid Gallbladder Lesions in Children: A Multicenter Study

“…With Caucasian children, malignant transformation has only been reported for secondary PLG. [15][16][17] Our multi-institutional study is the largest series ever reported, although the number of patients is still limited compared with the adult population. 18 All of the lesions were isolated PLG, except one case with a delayed diagnosis of metachromatic leukodystrophy.…”

Gallbladder cancer in a patient with Miller‐Dieker syndrome

“…However, there have been very few reported cases of gallbladder cancer in children. In fact, to our knowledge, there are only four paediatric cases in the literature 3–6. One of these patients had a gallstone 4 and the other had a choledochal cyst 5 as a risk factor.…”

“…One of these patients had a gallstone 4 and the other had a choledochal cyst 5 as a risk factor. The third patient had achondroplasia as an associated disorder 6.…”

The natural history and significance of ultrasonographically defined polypoid lesions of the gallbladder in children

“…Most children who have developed a gallbladder malignancy had other associated disorders including anomalous arrangement of the pancreaticobiliary duct, metachromatic leukodystrophy, or achondroplasia. There are reports of gallbladder malignancy in otherwise healthy Navajo Indian children and one in a 9-year-old Japanese girl [47][48][49][50].…”