Gallbladder Adenosquamous Cancer With Situs Inversus Totalis: A Case Report and Literature Review

Abstract

Background: Situs inversus totalis (SIT) is a rare genetic congenital disease, characterized by complete right-left inversion of all the internal organs. We herein describe a meaningful case which was diagnosed as gallbladder adenosquamous carcinoma, a rare histology type of gallbladder cancer, with SIT. Case presrntaton: A 59-year-old Chinese woman was admitted for persistent epigastric distention and intermittent abdominal pain. The abdominal CT scan revealed a huge mass at the gallbladder bottom, involving the adjacent transverse colon and liver. En-bloc radical resection of the gallbladder cancer, including partial colonectomy and hepatectomy with regional node dissection, followed by colocolostomy and Roux-en-Y choledochojejunostomy, was successfully performed Pathology analysis indicated an adenosquamous carcinoma with positive adenocarcinoma marker (CK7, CK19) and squamous carcinoma markers (CK5/6, P63). Conclusion: The SIT anomaly might increase the risk of malignancies by sharing genome mutations, suggesting the importance of surveillance in the SIT settings.

Successful management of ectopic kidney stones in a patient with situs inversus totalis: a rare case report

“…SIT is frequently associated with kartagener syndrome, which describes a constellation of cardiovascular [ 6 ] and hepatobiliary abnormalities [ 7 ]. Renal anomalies, including agenesis [ 8 ], dysplasia [ 9 ], and hypoplasia [ 10 ] are the most prominent reported association with SITs. Genes might support this anomaly [ 11 ], as similar cases of SIT were reported in our patient’s family (his brother and daughter).…”