Gallbladder Adenomyomatosis Mimicking Carcinoma: A Diagnostic Dilemma

Mahajan, Abhishek; Sripathi, Smiti

doi:10.1200/jgo.2016.005249

Cited by 10 publications

(17 citation statements)

References 11 publications

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“…In our case, the patient presented with acute cholecystitis. Without timely treatment, this can progress to gangrene and perforation [ 12 , 13 , 14 ]. For these reasons, in our case, the indication for surgery is given.…”

Section: Discussionmentioning

confidence: 99%

Diffuse Gallbladder Adenomyomatosis with an Inflammatory Complication in an Adult

Hoang

Van

Nguyen

et al. 2021

Case Rep Gastroenterol

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Gallbladder adenomyomatosis (GA) is a benign alteration of the gallbladder wall. There are three types involved: segmental, fundal, and diffuse pattern; the last type is very rare. Ultrasound is the imaging method of choice for diagnosing that shows Rokitansky-Aschoff sinuses with cholesterol deposition creating comet-tail artifacts. Asymptomatic GA does not require surgery in case there are no malignant lesions defined by imaging diagnosis. We present the rare case of a 51-year-old man who was admitted to hospital due to abdominal pain concomitant with inflammatory syndrome. Imaging and histological findings were appropriate to diagnose diffuse GA and complication of cholecystitis.

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Section: Discussionmentioning

confidence: 99%

Diffuse Gallbladder Adenomyomatosis with an Inflammatory Complication in an Adult

Hoang

Van

Nguyen

et al. 2021

Case Rep Gastroenterol

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“…GA, or adenomyomatous hyperplasia, is a benign hyperplasia of the gallbladder wall and is a relatively common lesion, accounting for 9% of cholecystectomy specimens [ 5 , 6 ]. It is most predominantly found in women in their 50s with the majority presenting with complaints of chronic right upper quadrant pain or with leucocytosis of atypical acute cholecystitis [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Dysplasia or carcinoma usually occurs in the epithelial layer of GA, and several authors believe that the cause of cancer development is due to gallstones, chronic inflammation, and dysplastic changes rather than due to the tumor itself. Thus, GAs are not considered malignant lesions [ 1 , 3 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

Diffuse Gallbladder Adenomyomatosis in a Child

Pham¹,

Xuan²,

Dang³

2021

Cureus

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Adenomyomatosis of the gallbladder is a benign condition, usually occurring in middle age, in which the epithelium of the gallbladder proliferates and the gallbladder wall thickens with the presence of Rokitansky-Aschoff sinuses (RAS). The diffuse form is an unusual subtype of adenomyomatosis. Herein, we describe a 17-year-old female who presented with dull and intermittent pain in the right hypochondriac region for more than a month. Ultrasound followed by magnetic resonance imaging showed marked diffuse gallbladder wall thickening. A gross cholecystectomy specimen showed a diffusely enlarged gallbladder. The final diagnosis of gallbladder adenomyomatosis (GA) was confirmed by the histopathologic appearance of muscular and epithelial hyperplasia, contributing to mural thickening with epithelial invaginations forming the pathognomonic intramural diverticula known as the RAS. This case highlights that the diffuse form of GA is uncommon and is often accompanied by chronic inflammation, sometimes requiring differential diagnosis from gallbladder malignancies, especially when there is no image showing a “comet tail” of cholesterol crystals in the wall.

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“…Benign neoplasms and tumor-like lesions of the gallbladder and the extrahepatic bile ducts are infrequent, and diagnosis of these lesions are often difficult to establish on the basis of signs and symptoms. 1 , 2 Of these entities, adenomatous hyperplasia, with characteristic histopathological features of hyperplasia of metaplastic pyloric-type glands and of deep-seated glands in the absence of cellular atypia of the gallbladder, is uncommon. 2 These histological changes result in a thickened and nodular gallbladder mucosa.…”

Section: Introductionmentioning

confidence: 99%

Adenomatous Hyperplasia of the Gallbladder in the Setting of Mirizzi Syndrome, Mimicking Adenocarcinoma of the Gallbladder

Odongo

Dreque

Bongomin

et al. 2021

IMCRJ

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Background Adenomatous hyperplasia (AH) is an uncommon benign lesion of the gallbladder (GB), predominantly seen in men. AH is commonly confused with malignant GB neoplasms in the setting of chronic cholecystitis and gallstones. There is a scarcity of published literature on AH, suggesting its rarity and the need for this case report. Case Presentation A 24-year-old woman from Western Uganda presented with signs and symptoms consistent with extrahepatic biliary obstruction. Trans-abdominal ultrasound scan revealed cholecystomegaly (13.9 cm by 4.29 cm), thickened GB wall at 5.2 mm, with a poorly defined hypoechoic polypoid solid mass involving the fundal body of the GB. Explorative laparotomy with cholecystectomy and lymph node sampling was performed. Histopathological examination was consistent with adenomatous hyperplasia of the GB. The symptoms and laboratory values improved on follow-up in the clinic after laparotomy. Conclusion Adenomatous hyperplasia may be misdiagnosed as a malignant GB neoplasm, especially in the setting of chronic cholecystitis and gallstones. If a correct histopathological diagnosis is made, no further diagnostic work-up is necessary following surgical interventions.

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Gallbladder Adenomyomatosis Mimicking Carcinoma: A Diagnostic Dilemma

Cited by 10 publications

References 11 publications

Diffuse Gallbladder Adenomyomatosis with an Inflammatory Complication in an Adult

Diffuse Gallbladder Adenomyomatosis with an Inflammatory Complication in an Adult

Diffuse Gallbladder Adenomyomatosis in a Child

Adenomatous Hyperplasia of the Gallbladder in the Setting of Mirizzi Syndrome, Mimicking Adenocarcinoma of the Gallbladder

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