Gall bladder emptying in severe idiopathic constipation

Penning, Corine; Gielkens, H. A. J.; Delemarre, J. B. V. M.; Lamers, C. B. H. W.; Masclee, Ad

doi:10.1136/gut.45.2.264

Cited by 30 publications

(25 citation statements)

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“…In the subset of constipated patients with slow transit, both delayed gastric emptying and impaired gallbladder contraction have been described, but no association between these alterations and specific dyspeptic symptoms has been reported [1, 3, 5]. …”

Section: Discussionmentioning

confidence: 99%

“…An altered function of GI tract regions proximal to the colon has been described in chronic constipation, supposedly underlying the dyspeptic symptoms [1, 3, 4, 6]. …”

Section: Discussionmentioning

confidence: 99%

“…It has been hypothesized that constipation is part of a generalized gastrointestinal (GI) motor disorder in which proximal GI motility can also be impaired [1,2,3,4]. Indeed, alterations in small bowel motility, gastric emptying and gallbladder contraction have been reported in chronically constipated patients [1,2,3,4,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, alterations in small bowel motility, gastric emptying and gallbladder contraction have been reported in chronically constipated patients [1,2,3,4,5,6]. …”

Section: Introductionmentioning

confidence: 99%

“…Penning et al [1, 3] have shown that in the subgroup of patients with slow transit chronic constipation, the reduced colonic motility may be responsible for dyspeptic symptoms, probably by influencing gastric emptying rate, or gallbladder responses. But, again, whether such changes in motor functions translate into different dyspeptic symptoms is uncertain.…”

Section: Introductionmentioning

confidence: 99%

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Symptoms and Pathophysiological Correlations in Patients with Constipation and Functional Dyspepsia

et al. 2005

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Introduction: Patients with constipation often report dyspeptic symptoms, but whether constipation is associated with specific dyspeptic symptoms and altered gastrointestinal (GI) motility, remains to be established. Our aim was to study symptoms association and GI motility parameters in patients with constipation and functional dyspepsia. Patients and Method: 42 patients with different symptoms and severity of constipation and dyspepsia were enrolled. Scintigraphic gastric emptying, colonic transit time and gallbladder contraction were studied in all subjects. Results: No significant association was observed between individual symptoms of constipation and dyspepsia. Patients with more severe constipation did not have higher dyspepsia severity scores. Colonic transit time, gastric half emptying and gallbladder contraction were not significantly correlated. Although patients with severe nausea had faster colonic transit than those with absent/mild symptom (19 ± 2 vs. 48 ± 7 h; p < 0.05), the multivariate analysis only revealed a significant association between severe postprandial fullness, delayed t_1/2 (OR 1.05, CI 1–1.1) and impaired gallbladder contraction (OR 0.94, CI 0.89–0.99). Conclusions: Constipation was not associated with severity, or any particular dyspeptic symptom. Although motor abnormalities of both colon and proximal GI tract regions existed in the subset of constipated dyspeptic patients, they did not seem associated with the genesis of different dyspeptic symptoms.

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Section: Discussionmentioning

confidence: 99%

“…An altered function of GI tract regions proximal to the colon has been described in chronic constipation, supposedly underlying the dyspeptic symptoms [1, 3, 4, 6]. …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Indeed, alterations in small bowel motility, gastric emptying and gallbladder contraction have been reported in chronically constipated patients [1,2,3,4,5,6]. …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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