Galenic formulations of
            <i>Cannabis sativa</i>
            : comparison of the chemical properties of extracts obtained by simple protocols using lipidic vehicles

Aguirre, Matías Ezequiel; Orallo, Dalila Elisabet; Suarez, Patricia Alejandra; Ramírez, Cristina L.

doi:10.1080/14786419.2023.2184357

Cited by 4 publications

(2 citation statements)

References 25 publications

(6 reference statements)

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“…However, although they tested different formulations (liquids, semisolids), they only investigated Frontiers in Pharmacology frontiersin.org pure CBD and not extracts or other cannabinoids. Majority of the studies have aimed to the development of innovative methods for the preparation of cannabis galenic oil formulations (Società Italiana Farmacisti Preparatori, 2016;Casiraghi et al, 2018;Baratta et al, 2019;Ternelli et al, 2020;Baratta et al, 2021) and their quality assessment (Bettiol et al, 2019;Dei Cas et al, 2020), or cannabinoid extraction using lipid-based vehicles (Aguirre et al, 2023). Nevertheless, Aguirre et al's work did not focus on stability testing of the prepared formulations.…”

Section: Discussionmentioning

confidence: 99%

Phytocannabinoid-rich galenic preparations for topical administration: extraction and stability testing

Kaczorová,

Peč,

Béres

et al. 2023

Front. Pharmacol.

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Although medical cannabis was legalized in Czechia in 2013 and its use in topical treatments of skin disorders is now allowed, galenic formulations prepared from medical cannabis have not been widely implemented in the Czech healthcare system. One of the main reasons is the lack of a straightforward standardized protocol for their preparation. Cannabinoids, e.g., cannabidiol (CBD) and tetrahydrocannabinol (THC), have been shown to have therapeutic effects on various skin conditions, such as atopic dermatitis, psoriasis, scleroderma, acne and skin pigmentation. Recognizing the potential of dermatological treatment with medical cannabis, the present study aimed to evaluate the extraction capacity of various pharmaceutical bases for cannabinoids and the stability of prepared galenic formulations for dermatological applications with respect to cannabinoid content. The results showed that the stability of cannabinoids in formulations depended on the bases’ physical and chemical properties. The highest THC decomposition was observed in cream bases and Vaseline, with estimated percentage loss of total content of up to 5.4% and 5.6% per week, respectively. In contrast, CBD was more stable than THC. Overall, the tested bases were comparably effective in extracting cannabinoids from plant material. However, olive oil and Synderman bases exhibited the highest cannabinoid extraction efficiencies (approximately 70%) and the best storage stabilities in terms of the content of monitored compounds. The proposed preparation protocol is fast and easily implementable in pharmacies and medical facilities.

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Section: Discussionmentioning

confidence: 99%

Phytocannabinoid-rich galenic preparations for topical administration: extraction and stability testing

Kaczorová,

Peč,

Béres

et al. 2023

Front. Pharmacol.

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“…This step was conducted twice to enhance the efficacy of purification outcomes. The resultant product underwent characterization utilizing High-performance Liquid Chromatography (HPLC) [ 20 ]. Quantification of cannabidiol (CBD) to ascertain its degree of purity was executed employing a reverse-phase Zorbax SB-Aq column with dimensions of 4.6 mm ID × 250 mm, possessing a particle size of 5 µm.…”

Section: Methodsmentioning

confidence: 99%

Anthelmintic Effect of Cannabidiol against Echinococcus granulosus sensu stricto

Albani,

Fuentes,

Ramírez

et al. 2024

TropicalMed

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Cystic echinococcosis is a global parasitic zoonosis caused by infection with the larval stage of Echinococcus granulosus sensu lato. Cystic echinococcosis affects more than 1 million people worldwide, causing important economic costs in terms of management and livestock associated losses. Albendazole is the main drug used in treating human cystic echinococcosis. In spite of this, its low aqueous solubility, poor absorption, and consequently erratic bioavailability are the cause of its chemotherapeutic failures. Based on the described problem, new treatment alternatives urgently need to be developed. The aim of the present research was to study the in vitro and in vivo efficacy of cannabidiol (CBD), the second most abundant component of the Cannabis sativa plant, was demonstrated against E. granulosus sensu stricto. CBD (50 µg/mL) caused a decrease in protoscoleces viability of 80 % after 24 h of treatment which was consistent with the observed tegumental alterations. Detachment of the germinal layer was observed in 50 ± 10% of cysts treated with 50 µg/mL of CBD during 24 h. In the clinical efficacy study, all treatments reduced the weight of cysts recovered from mice compared with the control group. However, this reduction was only significant with ABZ suspension and the CBD + ABZ combination. As we could observe by the SEM study, the co-administration of CBD with ABZ suspension caused greater ultrastructural alteration of the germinal layer in comparison with that provoked with the monotherapy. Further in vivo research will be conducted by changing the dose and frequency of CBD and CBD + ABZ treatments and new available CBD delivery systems will also be assayed to improve bioavailability in vivo.

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Long-term stability and bactericidal properties of galenic formulations of Cannabis sativa oils

Orallo,

Fuentes,

Benavidez

et al. 2024

Fitoterapia

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Galenic formulations of Cannabis sativa : comparison of the chemical properties of extracts obtained by simple protocols using lipidic vehicles

Cited by 4 publications

References 25 publications

Phytocannabinoid-rich galenic preparations for topical administration: extraction and stability testing

Phytocannabinoid-rich galenic preparations for topical administration: extraction and stability testing

Anthelmintic Effect of Cannabidiol against Echinococcus granulosus sensu stricto

Long-term stability and bactericidal properties of galenic formulations of Cannabis sativa oils

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