Galectin-receptor interaction: a key player in liver fibrosis induced by Schistosoma japonicum infection
Ziyun Huang,
Xingzhuo Liu,
Shiguang Huang
et al.
Abstract:Background
Schistosoma japonicum eggs lodge in the liver and induce a fibrotic granulomatous immune response in the liver of host. Galectin 3 (Gal-3) is a protein implicated in fibrosis in multiple organs. However, the pathology and molecular mechanisms promoting hepatic granuloma formation remain poorly understood.
Methods
To investigate the effect of blocking galectin-receptor interactions by α-lactose on liver immunopathology in mice with S. jap… Show more
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