2013
DOI: 10.1016/j.jcv.2013.10.022
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Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection

Abstract: Background Dengue virus (DENV) infection remains a major public health burden worldwide. Soluble mediators may play a critical role in the pathogenesis of acute DENV infection. Galectin-9 (Gal-9) is a soluble β-galactoside-binding lectin, with multiple immunoregulatory and inflammatory properties. Objective To investigate plasma Gal-9 levels as a biomarker for DENV infection. Study design We enrolled 65 DENV infected patients during the 2010 epidemic in the Philippines and measured their plasma Gal-9 and c… Show more

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Cited by 55 publications
(89 citation statements)
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References 27 publications
(27 reference statements)
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“…allergy patient who also had a skin rash and generalized itching (Chagan-Yasutan et al 2010). Accordingly, the Gal-9 level can increase in adverse drug phenomena, though the elevations were relatively small due to the size of the lesion.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…allergy patient who also had a skin rash and generalized itching (Chagan-Yasutan et al 2010). Accordingly, the Gal-9 level can increase in adverse drug phenomena, though the elevations were relatively small due to the size of the lesion.…”
Section: Discussionmentioning
confidence: 99%
“…An enzyme-linked immunosorbent assay was used to measure the levels of Gal-9 (Gal Pharma Co., Ltd., Takamatsu, Japan) and soluble IL-2 receptor (sIL-2R) (Cell free N IL-2R, Kyowa Medex, Japan) (Chagan-Yasutan et al 2013). Measurements were conducted in duplicate, and the mean value was used for analysis.…”
Section: Enzyme-linked Immunosorbent Assaymentioning
confidence: 99%
“…Recent studies revealed that humans infected with acute human immunodeficiency virus (HIV)-1 have extremely high plasma Gal-9 levels that rapidly decrease after treatment (Chagan-Yasutan et al 2009;Saitoh et al 2012). Furthermore, plasma Gal-9 levels were markedly elevated during the critical phase of acute dengue virus infection (Chagan-Yasutan et al 2013).…”
Section: Introductionmentioning
confidence: 99%
“…We have used LAMP to identify dengue genotypes in 27 out of 65 samples (42%). Amongst the 27 patients at SLH who were included in our study, Dengue virus 1, 2, 3, and 4 were found in 13, four, seven, and three patients, respectively (Chagan-Yasutan et al 2013).…”
Section: Loop-mediated Isothermal Amplification Assay As Point-ofcarementioning
confidence: 89%
“…Gal-9 levels tracked viral load, and were associated with multiple cytokines and chemokines including monocyte frequencies and hematologic variables of coagulation. We proposed that Gal-9 could serve as an important novel biomarker of acute dengue virus infection and reflect disease severity (Chagan-Yasutan et al 2013). It was also suggested that manipulating Gal-9 signals may have immunotherapeutic potential and could represent an alternative approach for improving immune responses to virus infections and/or vaccines (Merani et al 2015).…”
Section: Biomarkers For Severity And/or Resiliencementioning
confidence: 99%