Galectin-3 Reflects Mitral Annular Plane Systolic Excursion Being Assessed by Cardiovascular Magnetic Resonance Imaging

Abstract

Background. This study investigates whether serum levels of galectin-3 may reflect impaired mitral annular plane systolic excursion (MAPSE) in patients undergoing cardiac magnetic resonance imaging (cMRI). Methods. Patients undergoing cMRI during routine clinical care were included prospectively within an all-comers design. Blood samples for biomarker measurements were collected within 24 hours following cMRI. Statistical analyses were performed in all patients and in three subgroups according to MAPSE (MAPSE I: ≥11 mm, MAPSE II: ≥8 mm–<11 mm, and MAPSE III: <8 mm). Patients with right ventricular dysfunction (<50%) were excluded. Results. 84 patients were included in the study. Median LVEF was 59% (IQR 51–64%). Galectin-3 correlated significantly with NT-proBNP (r = 0.42, p = 0.0001). Galectin-3 increased significantly according to the different stages of impaired MAPSE (p = 0.006) and was able to discriminate both patients with impaired MAPSE <11 mm (area under the curve (AUC) = 0.645, p = 0.024) and <8 mm (AUC = 0.733, p = 0.003). Combining galectin-3 with NT-proBNP improved discrimination of MAPSE <8 mm (AUC 0.803, p = 0.0001). In multivariable logistic regression models galectin-3 was still associated with impaired MAPSE (MAPSE < 11 mm: odds ratio (OR) = 3.53, p = 0.018; MAPSE < 8 mm: OR = 3.18, p = 0.06). Conclusions. Galectin-3 reflects MAPSE being assessed by cardiac MRI.

Soluble ST2 and Galectin-3 and Progression of CKD

“…For example, volume overload is a key mechanism that likely contributes to both cardiac and kidney disease. Galectin-3 has been associated with increased pulmonary artery and biventricular pressures54, 55, 56 and decreased left ventricular function 57 ; thus, elevations in galectin-3 may reflect pathways that affect kidney function via renal venous congestion 58 . Inflammation is also likely an important mechanism in cardiorenal pathophysiology.…”

Intraobserver and interobserver reproducibility of M-mode and B-mode acquired mitral annular plane systolic excursion (MAPSE) and its dependency on echocardiographic image quality in children

“…Recently, a fully automatic algorithm for the detection of LV dysfunction based on MAPSE measurements was introduced [ 13 ]. Moreover, cardiac biomarkers like NT-proBNP, galectin-3 and high sensitivity troponin T and I reflect cardiac MRI derived MAPSE [ 14 , 15 ]. Finally, MAPSE was shown to be a relevant prognostic index.…”