Galectin-3 increase in endurance athletes

Hättasch, Robert; Spethmann, Sebastian; Boer, Rudolf A. de; Ruifrok, W. P.; Schattke, Sebastian; Wagner, Moritz; Schroeckh, Sabrina; Durmus, Tahir; Schimke, Ingolf; Sanad, Wasiem; Baumann, Gert; Borges, Adrian C.; Knebel, Fabian

doi:10.1177/2047487313492069

Cited by 31 publications

(34 citation statements)

References 33 publications

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“…Absolute and per cent increments were comparable between patients and controls. Qualitatively similar changes have been reported recently after physical endurance training in healthy subjects [20,21]. Of particular note, the similar daytime pattern of Galectin-3 and COMP and their incremental responses to physical challenge [19] may reflect that there is a link between Galectin-3 and COMP.…”

Section: Discussionsupporting

confidence: 83%

Within‐day variation and influence of physical exercise on circulating Galectin‐3 in patients with rheumatoid arthritis and healthy individuals

et al. 2015

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Galectin‐3 has been suggested as a pro‐inflammatory mediator in rheumatoid arthritis (RA). Previous studies have reported overexpression of Galectin‐3 in RA synovitis and increased levels in synovial fluid and serum in long‐standing RA compared with osteoarthritis and healthy controls. Our objectives were to study whether serum Galectin‐3 (1) exhibits circadian variation and/or (2) responds to exercise in RA and controls. The study on circadian patterns (1) comprised eleven patients with newly diagnosed RA, disease duration less than 6 months (ERA), 10 patients with long‐standing RA [5–15 years (LRA)] and 16 self‐reportedly healthy control subjects. During 24 h, 7 blood samples were drawn at 3‐h intervals starting at 10 a.m. through 10 p.m. and at 7 and 10 a.m. on the following day. The study on the effect of physical activity (2) included 10 patients with ERA, 10 with LRA and 14 controls. The participants underwent a standardized exercise programme and four blood samples were drawn before, during and after exercise. Serum Galectin‐3 was quantified by ELISA (R&D systems). (1) Galectin‐3 was increased at baseline in both RA subsets (P = 0.08). There were no diurnal oscillations (P = 0.85). Day‐to‐day variation amounted to 3%. (2) Baseline Galectin‐3 was increased in LRA versus controls and ERA (P < 0.01 and 0.05). Physical exercise induced 10–15% Galectin‐3 increments in RA and controls (P < 0.001) peaking after 1–3 h. To conclude, Galectin‐3 did not exhibit circadian variation. Day‐to‐day variation was 3%. Exercise elicited comparable increments in patients with RA of short and long duration and controls, approaching normal after 1–3 h.

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Section: Discussionsupporting

confidence: 83%

Within‐day variation and influence of physical exercise on circulating Galectin‐3 in patients with rheumatoid arthritis and healthy individuals

et al. 2015

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“…As previously mentioned, veteran athletes show an increase in markers of plasma fibrosis. 64,111 Endomyocardial biopsies in athletes with ventricular arrhythmias have provided some insight into the arrhythmogenic substrate in humans. Dello Russo and colleagues observed fibro-fatty replacement in 5 of 13 athletes and active myocarditis foci in 7 of 13 athletes with symptomatic ventricular arrhythmias but no apparent structural heart disease.…”

Section: [H2] Pathophysiology Of Gene-elusive Arvcmentioning

confidence: 99%

Diagnosis, pathophysiology, and management of exercise-induced arrhythmias

Guasch

Mont

2016

Nat Rev Cardiol

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The cardiovascular benefits of physical activity are indisputable. Nevertheless, growing evidence suggests that both atrial fibrillation and right ventricular arrhythmia can be caused by intense exercise in some individuals. Exercise-induced atrial fibrillation is most commonly diagnosed in middle-aged, otherwise healthy men who have been engaged in endurance training for >10 years, and is mediated by atrial dilatation, parasympathetic enhancement, and possibly atrial fibrosis. Cardiac ablation is evolving as a first-line tool for athletes with exercise-induced arrhythmia who are eager to remain active. The relationship between physical activity and right ventricular arrhythmia is complex and involves genetic and physical factors that, in a few athletes, eventually lead to right ventricular dilatation, followed by subsequent myocardial fibrosis and lethal ventricular arrhythmias. Sinus bradycardia and atrioventricular conduction blocks are common in athletes, most of whom remain asymptomatic, although incomplete reversibility has been shown after exercise cessation. In this Review, we summarize the evidence supporting the existence of exercise-induced arrhythmias and discuss the specific considerations for the clinical management of these patients.

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“…Recently, Gal-3 has been shown as a helpful tool for better management of heart dysfunction [16], because its plasma level is strongly associated with changes in left ventricular structure and function. Its level also increases after different forms of physical activity [17][18][19], but there is no data on the effect of SCUBA diving on Gal-3 plasma concentration.…”

Section: Introductionmentioning

confidence: 99%

Galectin-3 and Cardiovascular Biomarkers Reflect Adaptation Response to Scuba Diving

et al. 2020

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To understand better the adaptation response of the cardiovascular system (CVS) to self-contained underwater breathing apparatus (SCUBA) diving, Galectin-3 (Gal-3) and specific CVS biomarkers were measured in plasma of 16 male recreational divers before and after (30 min, 3 and 6 h) diving (total time of 30 min at 30 m depth) undertaken a after long non-dive period. The one-time SCUBA dive caused a significant increase in Gal-3, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity troponin-I (hs-TnI), and myoglobin immediately after diving. Whereas Gal-3 and myoglobin dropped down to the basal levels during the recovery period, NT-proBNP and hs-TnI concentration continued to increase. An immediate increase of vascular endothelial growth factor, detected immediately after diving, was followed by a significant decrease and return to the basal level, 3 and 6 h after diving, respectively. After a significant initial decrease, endothelin-1 increased during the recovery period, but did not return to the basal level. The observed changes in these biomarkers reflect comprehensive, but transient adaptation of CVS and muscular system to the specific environmental conditions during the SCUBA dive. Whether the recurrent activation of these adaption mechanisms due to repetitive dives has positive or negative effects on CVS remains to be elucidated.

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Galectin-3 increase in endurance athletes

Abstract: Plasma galectin-3 is substantially elevated in endurance athletes after running but does not correlate with cardiac function, other biomarkers, or myocardial fibrosis. In mice, we demonstrate that galectin-3 increase during endurance exercise originates primarily from skeletal muscle.

Cited by 31 publications

References 33 publications

Within‐day variation and influence of physical exercise on circulating Galectin‐3 in patients with rheumatoid arthritis and healthy individuals

Within‐day variation and influence of physical exercise on circulating Galectin‐3 in patients with rheumatoid arthritis and healthy individuals

Diagnosis, pathophysiology, and management of exercise-induced arrhythmias

Galectin-3 and Cardiovascular Biomarkers Reflect Adaptation Response to Scuba Diving

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