Galectin-3 Expression in Pancreatic Cell Lines Under Distinct Autophagy-Inducing Stimulus

Filho, Antônio Felix da Silva; Sousa, Lizandra Maia de; Consonni, Sílvio Roberto; Pitta, Maíra Galdino da Rocha; Carvalho, Hernandes F.; Rêgo, Moacyr Jesus Barreto de Melo

doi:10.1017/s1431927620024526

Cited by 5 publications

(5 citation statements)

References 61 publications

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“…Gal-3, a crucial regulator in cellular processes, modulates various signaling pathways, one of which is the Epidermal Growth Factor Receptor (EGFR)/AKT/ Forkhead Box O3 (FOXO3) pathway [61]. It has been elucidated that the interaction between Gal-3 and this pathway, along with others such as EGFR/ERK/ Runt-related Transcription Factor 1 (Runx1) and Bone Morphogenetic Protein (BMP)/smad/ Inhibitor of DNA Binding 3 (Id-3), plays pivotal roles in PDAC progression [61][62][63]. However, further studies are needed to consolidate these findings with other research, and a deeper understanding of the nuances involved is essential.…”

Section: Galectin-3 In Intracellular Signaling Pathways: Interactions...mentioning

confidence: 99%

“…In pancreatic ductal adenocarcinoma, Gal-3 plays a significant role in responding to ischemia and nutrient deprivation, conditions commonly found in the tumor microenvironment [61]. The expression of Gal-3 is modulated by these conditions, as evidenced by increased Gal-3 mRNA and protein levels in pancreatic cancer cell lines, such as PANC-1 and Mia PaCa-2, when exposed to hypoxic and nutrient-deprived environments [61].…”

Section: Galectin-3 Interaction With Ischemia and Nutrient Deprivatio...mentioning

confidence: 99%

“…Gal-3 potentially regulates this shift, resulting in alterations in key molecules like glucose transporter1 (GLUT-1), AMP-activated protein kinase (AMPK), and mammalian target of rapamycin (mTOR). By enhancing aerobic glycolysis and enzyme activities, Gal-3 ensures the necessary energy levels for cell survival in a deprived environment [61].…”

Section: Galectin-3 Interaction With Ischemia and Nutrient Deprivatio...mentioning

confidence: 99%

“…These include angiogenesis enhancement, immune modulation, and the uptake of extracellular content. Through the regulation of vascular availability and nutrient competition with immune cells, secreted Gal-3 contributes to the survival of PDAC cells in hostile microenvironments [61].…”

Section: Galectin-3 Interaction With Ischemia and Nutrient Deprivatio...mentioning

confidence: 99%

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Galectin-3’s Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential

Dimitrijevic Stojanovic,

Stojanovic,

Radosavljevic

et al. 2023

Biomolecules

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Galectin-3 (Gal-3) plays a multifaceted role in the development, progression, and prognosis of pancreatic ductal adenocarcinoma (PDAC). This review offers a comprehensive examination of its expression in PDAC, its interaction with various immune cells, signaling pathways, effects on apoptosis, and therapeutic resistance. Additionally, the prognostic significance of serum levels of Gal-3 is discussed, providing insights into its potential utilization as a biomarker. Critical analysis is also extended to the inhibitors of Gal-3 and their potential therapeutic applications in PDAC, offering new avenues for targeted treatments. The intricate nature of Gal-3’s role in PDAC reveals a complex landscape that demands a nuanced understanding for potential therapeutic interventions and monitoring.

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Section: Galectin-3 In Intracellular Signaling Pathways: Interactions...mentioning

confidence: 99%

Section: Galectin-3 Interaction With Ischemia and Nutrient Deprivatio...mentioning

confidence: 99%

Section: Galectin-3 Interaction With Ischemia and Nutrient Deprivatio...mentioning

confidence: 99%

Section: Galectin-3 Interaction With Ischemia and Nutrient Deprivatio...mentioning

confidence: 99%

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Galectin-3’s Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential

Dimitrijevic Stojanovic,

Stojanovic,

Radosavljevic

et al. 2023

Biomolecules

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“…Gal-3 may negatively regulates autophagy in melanoma cells, which is evidence by reduced the pro-survival function autophagy and consequent treatment resistance [ 157 ]. In pancreatic cell lines, Gal-3 is involved in the regulation of autophagy to maintain intracellular homeostasis under extreme conditions such as hypoxia and nutrient deficiency [ 158 ].…”

Section: Introductionmentioning

confidence: 99%

Galectins and galectin-mediated autophagy regulation: new insights into targeted cancer therapy

Liú

Zhu

2023

Biomark Res

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Galectins are animal lectins with specific affinity for galactosides via the conserved carbohydrate recognition domains. Increasing studies recently have identified critical roles of galectin family members in tumor progression. Abnormal expression of galectins contributes to the proliferation, metastasis, epithelial-mesenchymal transformation (EMT), immunosuppression, radio-resistance and chemoresistance in various cancers, which has attracted cumulative clinical interest in galectin-based cancer treatment. Galectin family members have been reported to participate in autophagy regulation under physiological conditions and in non-tumoral diseases, and implication of galectins in multiple processes of carcinogenesis also involves regulation of autophagy, however, the relationship between galectins, autophagy and cancer remains largely unclear. In this review, we introduce the structure and function of galectins at the molecular level, summarize their engagements in autophagy and cancer progression, and also highlight the regulation of autophagy by galectins in cancer as well as the therapeutic potentials of galectin and autophagy-based strategies. Elaborating on the mechanism of galectin-regulated autophagy in cancers will accelerate the exploitation of galectins-autophagy targeted therapies in treatment for cancer.

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The interrelation of galectins and autophagy

Zheng

Xia

et al. 2023

International Immunopharmacology

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Galectin-3 Expression in Pancreatic Cell Lines Under Distinct Autophagy-Inducing Stimulus

Abstract: Abstract

Cited by 5 publications

References 61 publications

Galectin-3’s Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential

Galectin-3’s Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential

Galectins and galectin-mediated autophagy regulation: new insights into targeted cancer therapy

The interrelation of galectins and autophagy

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