Galectin‐3 enhances atrial remodelling and arrhythmogenesis through CD98 signalling

Cheng, Wanli; Chen, Yao‐Chang; Li, Shao‐Jung; Lee, Ting‐I; Higa, Satoshi; Chung, Cheng Chih; Kao, Yu Hsun; Chen, Shih Ann; Chen, Yi‐Jen

doi:10.1111/apha.13784

Cited by 12 publications

(4 citation statements)

References 48 publications

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“…(35). Unexpectedly, we observed that atrial fibrillation was more frequent in profile 1 patients, underlining the newly identified role of both local and systemic inflammation on atrial fibrillation occurrence (45)(46)(47).…”

Section: Discussionsupporting

confidence: 52%

Soluble TREM-1 plasma levels are associated with acute kidney injury, acute atrial fibrillation and prolonged ICU stay after cardiac surgery- a proof-concept study

Vandestienne

Braik

Lavillegrand

et al. 2023

Front. Cardiovasc. Med.

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BackgroundCardiopulmonary bypass (CPB) during cardiac surgery leads to deleterious systemic inflammation. We hypothesized that TREM-1, a myeloid receptor shed after activation, drives systemic inflammation during CPB.MethodsProspective observational bi-centric study. Blood analysis (flow cytometry and ELISA) before and at H2 and H24 after CPB. Inclusion of adult patients who underwent elective cardiac surgery with CPB.ResultsTREM-1 expression on neutrophils decreased between H0 and H2 while soluble (s)TREM-1 plasma levels increased. sTREM-1 levels increased at H2 and at H24 (p < 0.001). IL-6, IL-8, G-CSF and TNF-α, but not IL-1β, significantly increased at H2 compared to H0 (p < 0.001), but dropped at H24. Principal component analysis showed a close relationship between sTREM-1 and IL-8. Three patterns of patients were identified: Profile 1 with high baseline sTREM-1 levels and high increase and profile 2/3 with low/moderate baseline sTREM-1 levels and no/moderate increase overtime. Profile 1 patients developed more severe organ failure after CPB, with higher norepinephrine dose, higher SOFA score and more frequently acute kidney injury at both H24 and H48. Acute atrial fibrillation was also more frequent in profile 1 patients at H24 (80% vs. 19.4%, p = 0.001). After adjustment on age and duration of CPB, H0, H2 and H24 sTREM-1 levels remained associated with prolonged ICU and hospital length of stay.ConclusionsBaseline sTREM-1 levels as well as early kinetics after cardiac surgery identified patients at high risk of post-operative complications and prolonged length of stay.

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Section: Discussionsupporting

confidence: 52%

Soluble TREM-1 plasma levels are associated with acute kidney injury, acute atrial fibrillation and prolonged ICU stay after cardiac surgery- a proof-concept study

Vandestienne

Braik

Lavillegrand

et al. 2023

Front. Cardiovasc. Med.

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“…47 NF-κB can down regulate calcium channels and then cause AF. 48 Atrial heterogeneity is associated with varying degrees of iron infiltration into the myocardium. P-wave dispersion is the difference between the same patient's maximum P-wave duration and the minimum P-wave duration.…”

Section: Oxidative Stressmentioning

confidence: 99%

“…Another mechanism is that oxidative stress activates nuclear factors‐κB(NF‐κB) 47 . NF‐κB can down regulate calcium channels and then cause AF 48 …”

Section: Oxidative Stressmentioning

confidence: 99%

Iron and atrial fibrillation: A review

Liu

Yang

et al. 2023

Pacing Clinical Electrophis

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Atrial fibrillation (AF), one of the most common arrhythmias in clinical practice, is classified into paroxysmal, persistent, and permanent AF according to its duration. The development of AF is associated with increased cardiovascular morbidity and mortality. However, the exact etiology of this disease remains poorly understood. Recent studies found disorders of iron metabolism might be involved in the progression of AF. Abnormal iron metabolism in cardiomyocytes provides arrhythmogenic substrates through a variety of mechanisms, including calcium mishandling, ion channel remodeling, and oxidative stress overaction. Interestingly, in AF patients with iron overload, interventions on iron metabolism, such as iron chelators and ferroptosis inhibitors, has been shown to prevent AF via reducing ferroptosis. Herein, we review the possible mechanisms, consequences, and therapeutic implications of altered atrial iron handling for AF pathophysiology.

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“…Gal-3 poses pro-fibrotic effects upon the atrial interstitium, promoting arrhythmogenesis through CD98 (its membrane surface receptor) signaling [ 48 ]. As fibrosis is the main precipitant factor for the development of atrial fibrillation (AF), the biomarker role of Gal-3 in AF has been proposed [ 49 ].…”

Section: Gal-3 and Cardiac Remodelingmentioning

confidence: 99%

The Role of Galectin-3 in Predicting Congenital Heart Disease Outcome: A Review of the Literature

Făgărășan

Săsăran

Gozar

et al. 2023

IJMS

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Galectin-3 (Gal-3) is a novel pro-fibrotic biomarker that can predict both right and left cardiac dysfunction caused by various cardiovascular conditions. Its expression seems to be progressively altered with evolving cardiac remodeling processes, even before the onset of heart failure. Hence, Gal-3 has been found to be an individual predictor of acute and chronic heart failure or to serve as part of an integrated biomarker panel that can foresee adverse cardiac outcomes. In congenital heart disease (CHD), Gal-3 correlates with cardiac mortality and complications in both children and adults and is proposed as a therapeutic target in order to reverse the activation of pro-fibrosis pathways that lead to heart failure. Positive associations between serum Gal-3 levels, post-operatory hospitalization rates, complications and ventricular dysfunction have also been reported within studies conducted on patients with CHD who underwent corrective surgery. Thus, this review tried to address the potential utility of Gal-3 in patients with CHD and particularly in those who undergo corrective surgery. The heterogeneity of the literature data and the lack of validation of the results obtained by the current studies on larger cohorts cannot be neglected, though. Further longitudinal research is required to establish how Gal-3 can relate to long-term outcomes in pediatric CHD.

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Galectin‐3 enhances atrial remodelling and arrhythmogenesis through CD98 signalling

Cited by 12 publications

References 48 publications

Soluble TREM-1 plasma levels are associated with acute kidney injury, acute atrial fibrillation and prolonged ICU stay after cardiac surgery- a proof-concept study

Soluble TREM-1 plasma levels are associated with acute kidney injury, acute atrial fibrillation and prolonged ICU stay after cardiac surgery- a proof-concept study

Iron and atrial fibrillation: A review

The Role of Galectin-3 in Predicting Congenital Heart Disease Outcome: A Review of the Literature

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