Galectin-3: A Novel Biomarker Predicts Sudden Cardiac Death in Hypertrophic Cardiomyopathy

Emet, Samim; Dadashov, Mubariz; Sonsöz, Mehmet Rasih; Çakır, Mustafa; Yılmaz, Mustafa; Elıtok, Ali; Bilge, Ahmet Kaya; Mercanoğlu, Fehmi; Öncül, Aytaç; Adalet, Kâmil; Onur, Imran

doi:10.1016/j.amjms.2018.08.013

Cited by 12 publications

(11 citation statements)

References 15 publications

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“…11 Our recent study indicated Gal-3 gene deletion had no effect on the extent of cardiac fibrosis, 10 however it was unknown whether deletion of Gal-3 would reduce the frequency of VTA considering that some studies implicated such possibility of Gal-3 in addition to its pro-fibrotic effect. [21][22][23][24] Our results reveal lack of change in the severity of VTA by Gal-3 gene deletion in the TG mice. This finding is not entirely unexpected considering the fact that the amount of cardiac fibrosis is comparable between TG/ KO versus TG counterparts in this model.…”

Section: Discussionmentioning

confidence: 55%

“…In addition to the structural remodelling, electrophysiological remodelling also contributes to the onset of arrhythmias 11 . Our recent study indicated Gal‐3 gene deletion had no effect on the extent of cardiac fibrosis, 10 however it was unknown whether deletion of Gal‐3 would reduce the frequency of VTA considering that some studies implicated such possibility of Gal‐3 in addition to its pro‐fibrotic effect 21‐24 . Our results reveal lack of change in the severity of VTA by Gal‐3 gene deletion in the TG mice.…”

Section: Discussionmentioning

confidence: 60%

“…The use of isoflurane inhalation is able to maintain HR at the level close to the conscious state, but would reduce HRV as shown by previous studies. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] Nevertheless, such influence by anaesthesia would be comparable between nTG and TG mice and the disease-associated variation of R-R intervals remains at a significant level. In the Interestingly, we noticed significant differences, between TG and TG/KO mice, in a few nonlinear-domain indices, including FuEn, SampEn and LZC, albeit HR or linear-domain indices were not altered in TG/KO relative to that of TG mice.…”

Section: Discussionmentioning

confidence: 99%

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Association between heart rate variability indices and features of spontaneous ventricular tachyarrhythmias in mice

Zhao

Nguyen

et al. 2020

Clin Exp Pharma Physio

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Direct evidence is limited for the association between heart rate variability (HRV) indices and ventricular tachyarrhythmias (VTAs). While galectin-3 (Gal-3) is regarded as a causal factor for cardiac remodelling and a biomarker for arrhythmias, its regulation on VTAs and HVR is unknown. Using aged transgenic (TG) mice with cardiac overexpression of β 2 -adrenoceptors and spontaneous VTAs, we studied whether changes in HRV indices correlated with the severity of VTAs, and whether Gal-3 gene knockout (KO) in TG mice might limit VTA. Body-surface ECG was recorded (10-minute period) in 9-to 10-month-old mice of non-transgenic (nTG), TG and TG × Gal-3 knockout (TG/KO). Time-domain, frequency-domain and nonlinear-domain HRV indices were calculated using the R-R intervals extracted from ECG signals and compared with frequency of VTAs. TG and TG/KO mice developed frequent VTAs and showed significant changes in certain time-domain and nonlinear-domain HRV indices relative to nTG mice. The severity of VTAs in TG and TG/KO mice in combination, estimated by VTA counts and arrhythmia score, was significantly correlated with certain timedomain and nonlinear-domain HRV indices. In conclusion, significant changes in HRV indices were evident and correlated with the severity of spontaneous VTAs in TG mice. The frequency of VTA and HRV indices were largely comparable between TG and TG/KO mice. Deletion of Gal-3 in TG mice altered certain HRV indices implying influence by neuronally localized Gal-3 on autonomic nervous activity. K E Y W O R D S cardiomyopathy, galectin-3, heart rate variability, transgenic mouse model, ventricular tachyarrhythmia

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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Association between heart rate variability indices and features of spontaneous ventricular tachyarrhythmias in mice

Zhao

Nguyen

et al. 2020

Clin Exp Pharma Physio

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“…Of note, in this population, five-year risk of SCD is routinely assessed using a standard questionnaire outlined in the 2014 European Society of Cardiology guidelines [9]. The authors observed a positive correlation between the estimated five-year risk of SCD and serum levels of galectin-3, thus indicating an additive tool for SCD-prediction in this population [95].…”

Section: Galectin-3mentioning

confidence: 99%

Classic and Novel Biomarkers as Potential Predictors of Ventricular Arrhythmias and Sudden Cardiac Death

Shomanova

Ohnewein

Schernthaner

et al. 2020

JCM

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Sudden cardiac death (SCD), most often induced by ventricular arrhythmias, is one of the main reasons for cardiovascular-related mortality. While coronary artery disease remains the leading cause of SCD, other pathologies like cardiomyopathies and, especially in the younger population, genetic disorders, are linked to arrhythmia-related mortality. Despite many efforts to enhance the efficiency of risk-stratification strategies, effective tools for risk assessment are still missing. Biomarkers have a major impact on clinical practice in various cardiac pathologies. While classic biomarkers like brain natriuretic peptide (BNP) and troponins are integrated into daily clinical practice, inflammatory biomarkers may also be helpful for risk assessment. Indeed, several trials investigated their application for the prediction of arrhythmic events indicating promising results. Furthermore, in recent years, active research efforts have brought forward an increasingly large number of “novel and alternative” candidate markers of various pathophysiological origins. Investigations of these promising biological compounds have revealed encouraging results when evaluating the prediction of arrhythmic events. To elucidate this issue, we review current literature dealing with this topic. We highlight the potential of “classic” but also “novel” biomarkers as promising tools for arrhythmia prediction, which in the future might be integrated into clinical practice.

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“…Markers of endothelial dysfunction, remodeling, and immune cell infiltration are present at even early stages of HCM ( 74 ), potentially enabling earlier detection. Galectin-3, a systemic marker of cardiac fibrosis, is elevated in patients with HCM and is significantly higher in patients with a history of cardiac arrest, syncope, fatal arrhythmias, or sudden cardiac death ( 34 ). The extent of fibrosis can also be correlated with increases in Stromal Cell-Derived Factor (SDF) and Macrophage Chemoattractant Protein-1 (MCP-1), which increase immune cell recruitment ( 33 ), and chronic systemic increases in pro-fibrotic and inflammatory cytokines such as IL-1, TNF-α, and CRP ( 32 ).…”

Section: Inflammation-mediated Fibrotic Diseasementioning

confidence: 99%

The Immune and Inflammatory Basis of Acquired Pediatric Cardiac Disease

Jui

Singampalli

Shani

et al. 2021

Front. Cardiovasc. Med.

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Children with acquired heart disease face significant health challenges, including a lifetime of strict medical management, multiple cardiac surgeries, and a high mortality risk. Though the presentation of these conditions is diverse, a unifying factor is the role of immune and inflammatory responses in their development and/or progression. For example, infectious agents have been linked to pediatric cardiovascular disease, leading to a large health burden that disproportionately affects low-income areas. Other implicated mechanisms include antibody targeting of cardiac proteins, infection of cardiac cells, and inflammation-mediated damage to cardiac structures. These changes can alter blood flow patterns, change extracellular matrix composition, and induce cardiac remodeling. Therefore, understanding the relationship between the immune system and cardiovascular disease can inform targeted diagnostic and treatment approaches. In this review, we discuss the current understanding of pediatric immune-associated cardiac diseases, challenges in the field, and areas of research with potential for clinical benefit.

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Galectin-3: A Novel Biomarker Predicts Sudden Cardiac Death in Hypertrophic Cardiomyopathy

Cited by 12 publications

References 15 publications

Association between heart rate variability indices and features of spontaneous ventricular tachyarrhythmias in mice

Association between heart rate variability indices and features of spontaneous ventricular tachyarrhythmias in mice

Classic and Novel Biomarkers as Potential Predictors of Ventricular Arrhythmias and Sudden Cardiac Death

The Immune and Inflammatory Basis of Acquired Pediatric Cardiac Disease

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