Galbanic acid inhibits HIF-1α expression via EGFR/HIF-1α pathway in cancer cells

Eskandani, Morteza; Abdolalizadeh, Jalal; Hamishehkar, Hamed; Nazemiyeh, Hossein; Barar, Jaleh

doi:10.1016/j.fitote.2014.12.003

Cited by 47 publications

(26 citation statements)

References 43 publications

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“…Results showed that GBA dose-and time-dependently decreased the in vitro growth of OVCAR-3 human epithelial carcinoma cells with an IC50 of approximately 37, 12.1 and 10μM GBA at 24, 48 and 72h, respectively [14].…”

Section: Introductionmentioning

confidence: 97%

Combined spectroscopy and molecular modeling studies on the binding of galbanic acid and MMP9

Kiani

Almasi

Shokoohinia

et al. 2015

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 97%

Combined spectroscopy and molecular modeling studies on the binding of galbanic acid and MMP9

Kiani

Almasi

Shokoohinia

et al. 2015

International Journal of Biological Macromolecules

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“…The human gastric (AGS, CRL-1739) and umbilical vein/vascular endothelium cells (Huvec, ATCC: CRL-1730) were obtained from the National Cell Bank of Iran (Pasteur Institute, Tehran, Iran). 30 The mentioned cells were cultured at a seeding density of 1.0×10 4 cells/ cm 2 in RPMI 1640 medium containing 10 % FBS, 0.1 μg/μL concentration of penicillin/streptomycin and then incubated at 37°C and 5% CO 2 . After reaching the confluency of 40%-50%, the cultivated cells were treated with the conditioned-media composed of the co-cultured cells and bacteria for 4-6 hours.…”

Section: Cell Culture and Treatmentmentioning

confidence: 99%

Lactobacillus plantarum induces apoptosis in gastric cancer cells via modulation of signaling pathways in Helicobacter pylori

et al. 2019

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Introduction: Gastric cancer is considered the second prevalent cause of death around the world. This type of cancer is generally induced by Helicobacter pylori which could colonize within the gastric mucosa of the infected cases. To date, triple antibiotic therapy has routinely been utilized for controlling the H. pylori-induced infection. However, this strategy has been unsuccessful, in large part because of issues such as occurring point mutations in the H. pylori genome that can induce resistance to the antibiotics administered. Recently, it has been shown that different probiotics may have strong anti-cancer effects, in which they are capable of inhibiting H. pylori by both immunological and non-immunological mechanisms. Here, we aimed at finding possible anticancer impacts of the probiotic bacterium Lactobacillus plantarum on gastric cancer, AGS cells. Methods: The anti-cancer effects of the conditioned media of the locally isolated L. plantarum on the AGS cells were evaluated by different analyses such as flow cytometry, DNA ladder assay, DAPI staining, and RT-PCR. Results: Our findings showed that the conditioned media of L. plantarum can inhibit both H. pylori and AGS cells through up-/down-regulation of PTEN, Bax, TLR4, and AKT genes. The exudates of the probiotic L. plantarum bacteria can increase the expression of PTEN, Bax, and TLR4, and also decrease the expression of AKT gene. Conclusion: In agreement with different reports, our results proved the anti-cancer effects of the locally isolated L. plantarum through some immunological cell signaling pathways. Accordingly, it seems the probiotics could be considered as at least a complementary treatment for different types of malignancies.

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“…Although chemical drugs are some of the most important treatments for cancer, they have a number of side effects that can limit their use and efficacy. Thus, protection of cancer by natural agents has become a flourishing research field in recent years (Eskandani and others ; Kafil and others ; Moridi Farimani and others ). In this sense, several Heracleum species were evaluated for their antiproliferative activities.…”

Section: Biological Activitiesmentioning

confidence: 99%

The Genus Heracleum: A Comprehensive Review on Its Phytochemistry, Pharmacology, and Ethnobotanical Values as a Useful Herb

Bahadori

Dinparast

Zengin

2016

Comp Rev Food Sci Food Safe

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Heracleum species, also known as hogweed, are traditionally used as food additives, spices, and flavoring agents. Moreover, these plants are widely used in folklore medicine for the treatment of many disorders such as inflammation, flatulence, stomachache, epilepsy, psoriasis, and as carminative, wound healing, antiseptic, antidiarrheal, tonic, digestive, pain killer, analgesic, and anticonvulsant agents. The genus Heracleum has broad pharmacological activities: anti-inflammatory, antimicrobial, anticholinesterase, anti-oxidant, antiviral, cytotoxic, and anticarcinogenic. A total of 94 compounds have been isolated from plants of the Heracleum genus, all indicating vital biological activities. Also, about 50 compounds have been identified as major components in their essential oils. The genus is rich in several types of bioactive coumarin compounds, with huge potential for the discovery of new coumarins. Various parts of these plants produce essential oils (mainly aliphatic esters and monoterpenes) with a wide spectrum of biological activities. Heracleum species have great potential for applications in the food, cosmetics, perfumery, and pharmaceutical industries due to their broad ethnobotanical uses and pharmacological properties. Accordingly, this review aims to categorize updated and comprehensive information on ethnobotanical uses, phytochemistry, and pharmacology of Heracleum species in order to open new perspectives for future studies, including possible uses as functional ingredients in food products.

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Galbanic acid inhibits HIF-1α expression via EGFR/HIF-1α pathway in cancer cells

Cited by 47 publications

References 43 publications

Combined spectroscopy and molecular modeling studies on the binding of galbanic acid and MMP9

Combined spectroscopy and molecular modeling studies on the binding of galbanic acid and MMP9

Lactobacillus plantarum induces apoptosis in gastric cancer cells via modulation of signaling pathways in Helicobacter pylori

The Genus Heracleum: A Comprehensive Review on Its Phytochemistry, Pharmacology, and Ethnobotanical Values as a Useful Herb

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