Galaxolide and Irgacure 369 are novel environmental androgens

Li, Mingzhao; Ren, Wei; Wang, Pan

doi:10.1016/j.chemosphere.2023.138329

Cited by 4 publications

(1 citation statement)

References 61 publications

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“…Although there is no regulation for the 28 high-priority compounds recognized in NMRPs, they have been reported to cause toxicity, consistent with our study. For example, galaxolide has been reported to be a new environmental androgen, exerting toxicological effects on the development of male reproductive organs. DMF is a versatile solvent.…”

Section: Resultsmentioning

confidence: 99%

Screening and Evaluation of Children’s Sensitively Toxic Chemicals in New Mosquito Repellent Products Based on a Nationwide Investigation

Liu,

Jin,

et al. 2024

Environ. Sci. Technol.

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New mosquito repellent products (NMRPs) are emerging popular repellents among children. There are increasing reports on children's sensitization reactions caused by NMRPs, while regulations on their productions, sales, or usage are still lacking. One of the reasons could be the missing comprehensive risk assessment. We first conducted a nationwide investigation on children's NMRP usage preferences. Then, we high-throughput screened volatile or semivolatile organic chemicals (VOCs/ SVOCs) in five representative NMRPs by the headspace gas chromatography−orbitrap high-resolution mass spectrometry analytical method. After that, toxic compounds were recognized based on the toxicity forecaster (ToxCast) database. A total of 277 VOCs/SVOCs were recognized, and 70 of them were identified as toxic compounds. In a combination of concentrations, toxicities, absorption, distribution, metabolism, and excretion characteristics in the body, 28 chemicals were finally proposed as priority-controlled compounds in NMRPs. Exposure risks of recognized toxic chemicals through NMRPs by inhalation and dermal intake for children across the country were also assessed. Average daily intakes were in the range of 0.20−7.31 mg/kg/day for children in different provinces, and the children in southeastern coastal provinces were found to face higher exposure risks. By controlling the high-priority chemicals, the risks were expected to be reduced by about 46.8% on average. Results of this study are therefore believed to evaluate exposure risks, encourage safe production, and promote reasonable management of NMRPs.

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Section: Resultsmentioning

confidence: 99%