Galantamine: A Review Update

Abstract

Galantamine, like nor-belladine, is a benzazepine. Galanthus and other plants of the Amaryllidaceae are the most common sources of it. Galantamine is used to combat the muscle effects of gallamine triethiodide and tubocurarine by acting as a cholinesterase inhibitor. The review reveals the protective effects of galantamine on the functions and integrity of the liver, brain and memory impairment. Various independent studies have shown anti-Alzheimer, antioxidant, antidiabetic and neuroprotective effect of galantamine. The current review highlights current knowledge and the health-promoting effects of a drug known as galantamine. This review summarizes the current state in the pharmacology of galantamine, focusing on its effects on tolerance, dosage, drug interactions and pharmacological studies in animal models.
 Keywords: Galantamine, Pharmacology, Acetylcholinesterase inhibitor, Neuroprotective, Protective effect.

Pathogenesis of Alzheimer’s Disease and Diversity of 1,2,3-Triazole Scaffold in Drug Development: Design Strategies, Structural Insights, and Therapeutic Potential

“…Galantamine also maintained cognitive function and activities of daily living in patients with mild to moderate Alzheimer's disease. 100,101 Galantamine and cryspine A (interacting with CAS) and melatonin (interacting with PAS) have been observed to possess neuroprotective efficacies. Inspired from the fragments in the galantamine, cryspine A, and melatonin, Moleda et al discovered the dual-binding cholinesterase inhibitors which bind either from CAS or from PAS of the enzyme by using combinatorial libraries of azide and alkynes to enable the click reactions.…”

Monitoring of the use of spent grape pomace after industrial distillation as a potent antioxidant and enzymes inhibitor

“…Nowadays, commercial drugs such as acarbose and voglibose are used for the control of glycemic response as well as tacrine, and galantamine for inhibiting acetylcholinesterase activity. However, there is a big incidence of several side effects such as abdominal discomfort, diarrhoea and flatulence (Hameed et al ., 2022), chronic hepatotoxicity issues (Yang et al ., 2023), allergic reactions (rash, rash or itching), trouble with breathing or swallowing, the feeling of tightness in the chest (Kaur et al ., 2022). Therefore, the use of other alternatives with similar efficacy and reduced side effects is highly encouraged (Złotek et al ., 2020).…”