Galanin's implications for post-stroke improvement

Song, Jeong Sup; Kim, Oh Yoen

doi:10.5115/acb.2016.49.4.223

Cited by 5 publications

(3 citation statements)

References 98 publications

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“…Relevant clinical data 10 show that patients with ischemic stroke are very prone to depression after onset, characterized by low spirits, lack of interest and sense of worthlessness, which are mostly accompanied by sleep disorders, cognitive defects and physical symptoms. The meta-analysis found that the incidence of depression two weeks - seven years after stroke was as high as 33%.…”

Section: Discussionmentioning

confidence: 99%

Effects of paroxetine hydrochloride combined with idebenone on inflammatory factors and antioxidant molecules in treatment of depression after ischemic stroke

Yuan¹,

Chen²,

Huang³

2022

Pak J Med Sci

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Objectives: To evaluate the effects of paroxetine hydrochloride combined with idebenone on inflammatory factors and antioxidant molecules in the treatment of depression after ischemic stroke. Methods: Randomized controlled trial was adopted on 80 patients with depression after ischemic stroke were randomly divided into two groups, with 40 patients in each group at Xingtai Sanli Health Quannan Clinic from March 17, 2019 to December 20, 2021. Both groups were given basic treatment. On this basis, the control group was treated with paroxetine hydrochloride, while the study group was treated with paroxetine hydrochloride combined with idebenone. The clinical efficacy was evaluated using the Hamilton Rating Scale for Depression (HRSD) before and after treatment. Additionally, the difference in HRSD score after treatment and the improvement in inflammatory factors and antioxidant molecules were compared and analyzed between the two groups. Results: After treatment, the HRSD score of the study group was significantly improved compared with that of the control group (p= 0.00). The effective rate was 82.5% in the study group, which was significantly higher than 62.5% in the control group (p= 0.04). After treatment, TNF-a, CRP and IL-6 in the study group were significantly lower than those in the control group (p= 0.00). Serum SOD, TAC and CAT levels in the study group were significantly higher than those in the control group after treatment (SOD and TAC, p= 0.00; CAT, p= 0.01). The incidence of adverse reactions was 37.5% in the study group and 25% in the control group. Although the incidence of adverse reactions in the study group was higher than that in the control group, the difference was not statistically significant (p= 0.23). Conclusion: Paroxetine hydrochloride combined with idebenone in the treatment of depression after ischemic stroke can significantly improve HRSD score, enhance clinical efficacy, reduce the levels of inflammatory factors, and increase the levels of antioxidant factors, without a significant increase in adverse reactions. Therefore, it is a safe and effective treatment method. doi: https://doi.org/10.12669/pjms.39.1.5679 How to cite this: Yuan L, Chen T, Huang Z. Effects of paroxetine hydrochloride combined with idebenone on inflammatory factors and antioxidant molecules in treatment of depression after ischemic stroke. Pak J Med Sci. 2023;39(1):---------. doi: https://doi.org/10.12669/pjms.39.1.5679 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Effects of paroxetine hydrochloride combined with idebenone on inflammatory factors and antioxidant molecules in treatment of depression after ischemic stroke

Yuan¹,

Chen²,

Huang³

2022

Pak J Med Sci

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“…Studies by Kofler et al [ 13 ] showed that galanin is involved in skin immunity, as its expression was demonstrated to be upregulated in inflammation-remodeled tissue. In poststroke inflammation, galanin regulates the release of inflammatory cytokines and inflammatory cell infiltration in the brain [ 14 ]. Galanin regulates cellular responses by activating three distinct G-protein-coupled receptors, galanin receptor 1 (GalR1), GalR2, and GalR3, which diverge in their distributions, pharmacology, and signaling.…”

Section: Introductionmentioning

confidence: 99%

Galanin Coordinates Macrophage-Associated Fibro-Inflammatory Response and Mitochondrial Integrity in Myocardial Infarction Reperfusion Injury

Savchenko,

Kramar,

Todua

et al. 2024

IJMS

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Myocardial infarction activates an intense fibro-inflammatory reaction that is essential for cardiac remodeling and heart failure (HF). Bioactive peptide galanin plays a critical role in regulating cardiovascular homeostasis; however, its specific functional relevance in post-infarction fibro-inflammatory reprogramming remains obscure. Here, we show that galanin coordinates the fibro-inflammatory trajectory and mitochondrial integrity in post-infarction reperfusion injury. Aberrant deposition of collagen was associated with a marked increase in CD68-positive macrophage infiltration in cardiac tissue in mice subjected to myocardial ischemia/reperfusion (I/R) for 14 days compared to sham controls. Furthermore, we found that the myocardial expression level of a specific marker of M2 macrophages, CD206, was significantly down-regulated in I/R-challenged mice. In contrast, galanin treatment started during the reperfusion phase blunted the fibro-inflammatory responses and promoted the expression of CD206 in I/R-remodeled hearts. In addition, we found that the anti-apoptotic and anti-hypertrophic effects of galanin were associated with the preservation of mitochondrial integrity and promotion of mitochondrial biogenesis. These findings depict galanin as a key arbitrator of fibro-inflammatory responses to cardiac I/R injury and offer a promising therapeutic trajectory for the treatment of post-infarct cardiovascular complications.

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“…1 According to the location of the lesion, the size of the area of inadequate perfusion, and the amount of collateral blood flow, dysfunctions such as anxiety, depression, motor, sensory, cognitive, and communication disorders are observed in patients following a stroke. 2 A sensorimotor disorder might include somatosensory changes that impair movement control and joint stabilit. 1 During the stroke, the upper motor neuron is reached, with a change in muscle tone with sagging and weak muscles related to the glenohumeral joint.…”

Section: Introductionmentioning

confidence: 99%

Inter-and intra-rater analysis of hemiparetic shoulder abduction using PhysioPlay™

et al. 2019

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Changes in balance are observed in some hemiparetics following a stroke, generating significant physical, social, and economic impacts; thus, an assessment was developed to facilitate treatment plans for patients. Goniometry is currently used as an evaluation tool for range of motion (ROM); however, the development of exergames has brought a new perspective to the assessment, which uses a dynamic mechanism and has little subjectivity. Objective: This study evaluates the inter-and intra-rater reliability of ROM measurement of the shoulder abduction in post-stroke patients using the exergame PhysioPlay™. Method: Thirteen volunteer chronic stroke survivors, aged 58.23 ± 9.96 years (men and women), participated in this study. Two physiotherapists evaluated the abduction of the shoulder using goniometry and the exergame PhysioPlay™. A retest was performed one week later. Clinical trial registry number – RBR-55smwr. Results: The results of the analyses using intraclass correlation coeficient (ICC) showed an excellent inter- and intra-rater reliability level (r > 0.90; p < .05). The Pearson correlation between the maximum measures obtained in the goniometry and the software PhysioPlay™ showed a high correlation (r > 0.90, p= .001). Conclusion: The Kinect associated with the exergame PhysioPlay™ presented excellent reliability in capturing the ROM measure compared to the conventional goniometry.

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Galanin's implications for post-stroke improvement

Cited by 5 publications

References 98 publications

Effects of paroxetine hydrochloride combined with idebenone on inflammatory factors and antioxidant molecules in treatment of depression after ischemic stroke

Effects of paroxetine hydrochloride combined with idebenone on inflammatory factors and antioxidant molecules in treatment of depression after ischemic stroke

Galanin Coordinates Macrophage-Associated Fibro-Inflammatory Response and Mitochondrial Integrity in Myocardial Infarction Reperfusion Injury

Inter-and intra-rater analysis of hemiparetic shoulder abduction using PhysioPlay™

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