Galanin inhibition of vasoactive intestinal polypeptide release and circular muscle motility in the isolated perfused canine ileum

Fox-Threlkeld, J. E. T.; McDonald, Thomas J.; Cipris, S.; Woskowska, Z.; Daniel, E. E.

doi:10.1016/0016-5085(91)90381-t

Cited by 37 publications

(24 citation statements)

References 10 publications

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“…This fact strongly suggest that exact roles of this zinc transporter, just like in the case of other enteric neuronal active substances and enteric nervous system as a whole (Fox-Threlkeld et al 1991; Botella et al 1992; Furness 2008), clearly depend on the fragment of digestive tract.…”

Section: Discussionmentioning

confidence: 98%

“…In turn, functions of galanin within the GI tract are not quite clear and depend on animal species and intestinal fragment studied. It is known that GAL shows stimulating influence on the ileal muscles of the rat and pig (Botella et al 1992), while within the canine pylorus and ileum, it exhibits the relaxatory action (Fox-Threlkeld et al 1991). …”

Section: Discussionmentioning

confidence: 99%

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Zinc Transporter 3 (Znt3) as an Active Substance in the Enteric Nervous System of the Porcine Esophagus

Wojtkiewicz¹,

Makowska

Bejer-Oleńska³

et al. 2016

J Mol Neurosci

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Zinc transporter 3 (ZnT3), a member of the SLC 30 zinc transporter family, is involved in the transport of zinc ions from the cytoplasm into synaptic vesicles or intracellular organelles. The aim of the present study was to investigate for the first time the percentage of ZnT3-like immunoreactive (ZnT3-LI) neurons in the enteric nervous system (ENS) of the porcine esophagus and denotation of their neurochemical coding. Routine double- and triple-immunofluorescence labeling of cervical, thoracic, and abdominal fragments of esophagus for ZnT3 with protein gene product (PGP 9.5; used as pan-neuronal marker), nitric oxide synthase (NOS), somatostatin, vasoactive intestinal peptide (VIP), vesicular acetylcholine transporter (VAChT), neuropeptide Y (NPY), and galanin (GAL) was performed. The percentage of ZnT3-LI neurons in myenteric ganglia amounted to 50.2 ± 4.7, 63.4 ± 8.3, and 77.1 ± 1.1 % of all PGP 9.5-like immunoreactive neuronal cells in cervical, thoracic, and abdominal esophagus, respectively. In submucous ganglia, these values in particular parts of esophagus amounted to 46.3 ± 6.3, 81.0 ± 8.1, and 74.4 ± 4.4 %. Znt3 co-localized mainly with VAChT, NPY, GAL, NOS, and VIP, but the degree of co-localization depended on the “kind” of enteric ganglia and part of esophagus studied. The obtained results suggest that both ZnT3 and zinc ions may play important and various roles in the neuronal regulation of esophageal functions.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Zinc Transporter 3 (Znt3) as an Active Substance in the Enteric Nervous System of the Porcine Esophagus

Wojtkiewicz¹,

Makowska

Bejer-Oleńska³

et al. 2016

J Mol Neurosci

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“…For instance, it is known that GAL induces the contraction of muscles in the rat, guinea-pig, rabbit and pig (Botella et al, 1992), while in canine pylorus and ileum (Fox-Threlkeld et al, 1991) and guinea-pig ileum (Sternini et al, 2004) it displays the relaxatory activity.…”

Section: Resultsmentioning

confidence: 99%

Proliferative enteropathy (PE): Induced changes in galanin-like immunoreactivity in the enteric nervous system of the porcine distal colon

Gonkowski¹,

Burliński²,

Całka³

2009

Acta vet. (Beogr.)

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The aim of this study was to investigate the changes of galanin (GAL) like immonoreactivity in the porcine descending colon during proliferative entheropathy (PE). Accordingly, the distribution pattern of GAL - like immunoreactive (GAL-LI) nerve structures was studied by the immunofluorescence technique in the circular muscle layer, myenteric (MP), outer submucous (OSP) and inner submucous plexuses (ISP), as well as in the mucosal layer of the porcine descending colon under physiological conditions and during PE. In control animals GAL-LI perikarya have been shown to constitute 4.03 ± 0.1%, 6.67 ± 0.3% and 11.20 ± 0.5% in MP, OSP and ISP, respectively. PE caused changes in the GAL - like immunoreactivity, which differed in particular parts of the studied bowel segment. During PE the number of GAL-LI perikarya amounted to 2.90±0.5%, 8.42±1.0% and 21.72±1,4% within the MP, OSP and ISP, respectively. Moreover PE caused an increase in the number of GAL-LI nerve fibers in the colonic circular muscle and mucosal layers, as well as in all intramural plexuses, especially in ISP, where nearly every ganglion contained a very dense meshwork of the GAL-positive nerve fibers under the studied pathological factor. This study for the first time reports on changes in GAL-LI nerve structures of the porcine descending colon during Lawsonia intracellularis infection

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“…In dogs, galanin induces relaxation of jejunal smooth muscle cells (8). It inhibits the secretion of gastric mucosa cells and hormonesglucagon and insulin, regulates electrolyte transport across gastric mucosa, and probably demonstrates the neuroprotective effects (14,17,19).…”

Section: Discussionmentioning

confidence: 99%

“…These functions depend on the species and part of the digestive tract. For example GAL induces the contraction of the muscles in rat ileum (7), while in the canine pylorus and ileum it displays relaxatory activity (8). Moreover, galanin regulates the secretion of gastric acid and pancreatic enzymes, as well as modulates ion channels to control the secretion of other neurotransmitters (13,25,27).…”

Section: Introductionmentioning

confidence: 99%

Galanin - Immunoreactive Nerve Fibers in the Mucosal Layer of the Canine Gastrointestinal Tract During Inflammatory Bowel Disease

Rychlik

Gonkowski

Nowicki

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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The effect of inflammatory bowel disease (IBD) on the density of galanin -immunoreactive (GAL-IR) nerve fibers was determined in the mucosa of canine duodenum, jejunum, and descending colon. Fiber density was evaluated by a single immunofluorescence method in biopsy specimens obtained from healthy dogs and patients with variable severity of the disease. The density of GAL-IR nerve fibers was determined by the semi-quantitative method by counting fibers in the field of view (0.l mm 2 ). Fiber density was higher in dogs with moderate and severe IBD than in healthy animals. The results of the study suggest that GAL present in intestinal nerve fibers could play a role in the pathogenesis and development of canine IBD.

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Galanin inhibition of vasoactive intestinal polypeptide release and circular muscle motility in the isolated perfused canine ileum

Cited by 37 publications

References 10 publications

Zinc Transporter 3 (Znt3) as an Active Substance in the Enteric Nervous System of the Porcine Esophagus

Zinc Transporter 3 (Znt3) as an Active Substance in the Enteric Nervous System of the Porcine Esophagus

Proliferative enteropathy (PE): Induced changes in galanin-like immunoreactivity in the enteric nervous system of the porcine distal colon

Galanin - Immunoreactive Nerve Fibers in the Mucosal Layer of the Canine Gastrointestinal Tract During Inflammatory Bowel Disease

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