Galanin and the galanin antagonist M40 do not change fat intake in a fat-chow choice paradigm in rats

Corwin, Rebecca L.; Rowe, Paul M; Crawley, Jacqueline N.

doi:10.1152/ajpregu.1995.269.3.r511

Cited by 16 publications

(12 citation statements)

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“…Baclofen reduced shortening intake under the present limited access binge-type conditions. Previous reports have shown no effect of two peptides thought to be involved in the regulation of fat intake (galanin and enterostatin) using similar protocols [76][77][78]. Taken together, these findings indicate that food intake induced by limited access is different from food intake induced by other protocols.…”

Section: Discussionsupporting

confidence: 52%

Baclofen reduces fat intake under binge-type conditions

Buda-Levin

Wojnicki

Corwin

2005

Physiology & Behavior

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The GABA-B agonist baclofen reduces drug self-administration in rats and has shown promise clinically in the treatment of substance abuse. Baclofen generally does not reduce food intake in non-binge feeding protocols. In this study, baclofen was tested in a fat-binge protocol. Thirty male rats were divided into three groups (B: binge; FM: fat-matched; C: chow). B received a bowl of vegetable shortening for 2 h on Monday, Wednesday, and Friday (MWF) and continuous access to powdered chow (regular chow) in all phases. FM had continuous access to a regular chow+shortening mixture (FM chow) that provided the same proportion of shortening and regular chow that the B rats consumed in all phases. In addition, FM had the following: phase 1: no separate bowl of shortening; phase 2: 2-h MWF access to a separate bowl of shortening; phase 3, daily 2-h access to a separate bowl of shortening; C rats had continuous access to the regular chow in all phases. In addition, C had the following: phase 1: no separate bowl of shortening; phase 2: 2-h MWF access to a separate bowl of shortening; in phase 3, daily 2-h access to a separate bowl of shortening. Baclofen (1.0, 1.8 mg/kg, i.p.) reduced shortening intake regardless of access condition. Baclofen had no effect on, or stimulated, FM and regular chow intake. These results demonstrate that baclofen can reduce fat intake in rats under binge-type conditions. Furthermore, these results indicate that bingeing, as modeled in our protocol, is different from other forms of food intake and may share similarities with substance abuse.

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Section: Discussionsupporting

confidence: 52%

Baclofen reduces fat intake under binge-type conditions

Buda-Levin

Wojnicki

Corwin

2005

Physiology & Behavior

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“…Consistent with a mitogenic function, mice overexpressing GAL develop pituitary adenomas [11–12]. GAL induces its functional effects via three different G-protein coupled receptors, galanin receptor 1 (GALR1), GALR2 and GALR3 [13]. Since antagonistic roles have been reported for individual galanin receptors, it is necessary to characterize the signaling cascade of each GALR.…”

Section: Introductionmentioning

confidence: 99%

Rap1 mediates galanin receptor 2-induced proliferation and survival in squamous cell carcinoma

Banerjee

Henson

Russo

et al. 2011

Cellular Signalling

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Previously we showed that galanin, a neuropeptide, is secreted by human squamous cell carcinoma of the head and neck (SCCHN) in which it exhibits an autocrine mitogenic effect. We also showed that rap1, a ras-like signaling protein, is a critical mediator of SCCHN progression. Given the emerging importance of the galanin cascade in regulating proliferation and survival, we investigated the effect of GAL on SCCHN progression via induction of galanin receptor 2 (GALR2)-mediated rap1 activation. Studies were performed in multiple SCCHN cell lines by inducing endogenous GALR2, by stably overexpressing GALR2 and by downregulating endogenous GALR2 with siGALR2. Cell proliferation and survival, mediated by the ERK and AKT signaling cascades, respectively, were evaluated by functional and immunoblot analysis. The role of rap1 in GALR2-mediated proliferation and survival was evaluated by modulating expression. Finally, the effect of GALR2 on tumor growth was determined. GALR2 stimulated proliferation and survival via ERK and AKT activation, respectively. Knockdown or inactivation of rap1 inhibited GALR2-induced, AKT and ERK-mediated survival and proliferation. Overexpression of GALR2 promoted tumor growth in vivo. GALR2 promotes proliferation and survival in vitro, and promotes tumor growth in vivo, consistent with an oncogenic role for GALR2 in SCCHN.

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“…[13][14][15][16][17][18]23 As for NPY, time of brain sampling is a critical factor for the effect of an HF diet on galanin concentration in the PVN and median eminence. [13][14][15][16][17][18]23 As for NPY, time of brain sampling is a critical factor for the effect of an HF diet on galanin concentration in the PVN and median eminence.…”

Section: G Alanin and N Eurotensinmentioning

confidence: 99%

“…It preferentially stimulates carbohydrate intake 7,8 (see also Chapter 25 by Leibowitz in this book) and to a lesser extent fat intake. [13][14][15] Other experiments do not confirm this unique effect on fat intake 16,17 and/or suggested that individual food preferences might play a role in the feeding response to galanin injection. 9,10 Galanin, a 29-AA peptide, is synthetized in neurons of the PVN as well as in the ARC and other brain areas.…”

Section: Introductionmentioning

confidence: 99%

Quantitative and Macronutrient- Related Regulation of Hypothalamic Neuropeptide Y, Galanin, and Neurotensin

Beck¹

1999

Neural and Metabolic Control of Macronutrient Intake

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Galanin and the galanin antagonist M40 do not change fat intake in a fat-chow choice paradigm in rats

Cited by 16 publications

References 0 publications

Baclofen reduces fat intake under binge-type conditions

Baclofen reduces fat intake under binge-type conditions

Rap1 mediates galanin receptor 2-induced proliferation and survival in squamous cell carcinoma

Quantitative and Macronutrient- Related Regulation of Hypothalamic Neuropeptide Y, Galanin, and Neurotensin

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