Galangin-Loaded Gold Nanoparticles: Molecular Mechanisms of Antiangiogenesis Properties in Breast Cancer

Abstract

Angiogenesis is important for tissue during normal physiological processes as well as in a number of diseases, including cancer. Drug resistance is one of the largest difficulties to antiangiogenesis therapy. Due to their lower cytotoxicity and stronger pharmacological advantage, phytochemical anticancer medications have a number of advantages over chemical chemotherapeutic drugs. In the current study, the effectiveness of AuNPs, AuNPs-GAL, and free galangin as an antiangiogenesis agent was evaluated. Different physicochemical and molecular approaches have been used including the characterization, cytotoxicity, scratch wound healing assay, and gene expression of VEGF and ERKI in MCF-7 and MDA-MB-231 human breast cancer cell line. Results obtained from MTT assay show cell growth reduction in a time- and dose-dependent aspect; also, in comparison to individual treatment, a synergistic impact was indicated. CAM assay results demonstrated galangin-gold nanoparticle capacity to suppress angiogenesis in chick embryo. Additionally, altering VEGF and ERKI gene expression was recorded. Taken together, all the results can conclude that galangin-conjugated gold nanoparticles can be a promising antiangiogenesis supplemental drug in breast cancer treatment.

Anti-Giardia Activity of Gold Nanoparticle and Flavonoid-Loaded Gold Nanoparticles

“…8). The results of the current study agree with the finding of several studies (Alhadrami et al, 2021;Qaddoori & Al-Shmgani, 2023).…”

Integrating network pharmacology, bioinformatics, and experimental validation to unveil the molecular targets and mechanisms of galangin for treating hepatocellular carcinoma

“…Galangin is the main functional component extracted from Alpinia officinarum Hance [11,12]. Many studies have shown that galangin can inhibit the growth and invasion of various malignant tumors, including lung cancer [13], breast cancer [14], liver cancer [15], bladder cancer [16], and leukemia [17]. Its anticancer spectrum is relatively wide and has a good application prospect.…”

Synthesis and Characterization of Proteolytic Enzyme Loaded on Silver Nanoparticles

“…AgNO3 solution was prepared by dissolving 0.0618 g of AgNO3 in 100 ml of distilled water at 45 °C to obtain a 1 mM silver nitrate solution, then 2 ml of (1%) trisodium citrate was added. The solution was kept on a stirrer for minutes, and then stored until used at 4°C [8]. Freshly prepared bromelain with a final concentration of 10 mg/mL dissolved in distilled water was added to the AgNPs solution and stirred for 6 hours [9].…”