Galangin and Pinocembrin from Propolis Ameliorate Insulin Resistance in HepG2 Cells via Regulating Akt/mTOR Signaling

Liu, Yinkang; Liang, Xiali; Zhang, Gensheng; Kong, Lingjie; Peng, Wenjun; Zhang, Hongcheng

doi:10.1155/2018/7971842

Cited by 35 publications

(31 citation statements)

References 38 publications

(38 reference statements)

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“…A particularly interesting finding was the existence of strong dependencies between the concentrations of pinocembrin and galangin. Of note, these two compounds are reported to ameliorate insulin resistance [70]. Moderate correlations with regard to the pairs luteolin and quercetin, chrysin and pinocembrin, caffeic acid and pinocembrin, chrysin and apigenin, as well as chrysin and galangin were observed.…”

Section: Correlations Between Tested Parameters Of Honeymentioning

confidence: 90%

Antioxidant Activity and Phenolic Profile of Selected Organic and Conventional Honeys from Poland

et al. 2020

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Honey is a natural food product hypothesized to have significant health-beneficial value. The results of recent studies indicate that the biological activity of honey can also be ascribed to phenolic compounds and their antioxidant activity. The aims of this study were: To determine the phenolic profiles of several varieties of Polish honey and their correlation with various factors influencing the quality of honey, plus to verify the impact of production method (organic/conventional) and the pollen content on these profiles. In total, 11 organic and 11 conventional honey samples from Poland were investigated. The botanical origin of the samples was identified through melissopalynological analysis, whereas individual phenolic compounds were determined by the LC/MS analysis. The Folin–Ciocalteau assay was used for the determination of the total phenolic content (TPC). Moreover, the CIE L*a*b* color values were measured and matched with the above-mentioned parameters. The results of the study contribute to the discussion on the health benefits of organic farming. It was found that chrysin may act as a potential indicator compound. The study confirms the existence of the link between TPC and color, and it shows that there is a correlation between pinocembrin and galangin, two compounds that are reported to ameliorate insulin resistance.

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Section: Correlations Between Tested Parameters Of Honeymentioning

confidence: 90%

Antioxidant Activity and Phenolic Profile of Selected Organic and Conventional Honeys from Poland

et al. 2020

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“…This finding indicates that pinocembrin can be used as a preventive agent for kidney damage before injury. Pinocembrin may enhance the activities of hexokinase and pyruvate kinase via the Akt/mTOR signaling pathway, thereby improving insulin resistance [63]. In daily life, given its antibacterial and antioxidant activities, pinocembrin can be used as mouth cleaning agent and sunscreen [7,64].…”

Section: Pharmacological Effects Of Pinocembrinmentioning

confidence: 99%

Advances in Biosynthesis, Pharmacology, and Pharmacokinetics of Pinocembrin, a Promising Natural Small-Molecule Drug

et al. 2019

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Pinocembrin is one of the most abundant flavonoids in propolis, and it may also be widely found in a variety of plants. In addition to natural extraction, pinocembrin can be obtained by biosynthesis. Biosynthesis efficiency can be improved by a metabolic engineering strategy and a two-phase pH fermentation strategy. Pinocembrin poses an interest for its remarkable pharmacological activities, such as neuroprotection, anti-oxidation, and anti-inflammation. Studies have shown that pinocembrin works excellently in treating ischemic stroke. Pinocembrin can reduce nerve damage in the ischemic area and reduce mitochondrial dysfunction and the degree of oxidative stress. Given its significant efficacy in cerebral ischemia, pinocembrin has been approved by China Food and Drug Administration (CFDA) as a new treatment drug for ischemic stroke and is currently in progress in phase II clinical trials. Research has shown that pinocembrin can be absorbed rapidly in the body and easily cross the blood–brain barrier. In addition, the absorption/elimination process of pinocembrin occurs rapidly and shows no serious accumulation in the body. Pinocembrin has also been found to play a role in Parkinson’s disease, Alzheimer’s disease, and specific solid tumors, but its mechanisms of action require in-depth studies. In this review, we summarized the latest 10 years of studies on the biosynthesis, pharmacological activities, and pharmacokinetics of pinocembrin, focusing on its effects on certain diseases, aiming to explore its targets, explaining possible mechanisms of action, and finding potential therapeutic applications.

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“…Isolated hepatocytes may be a desirable model in which to investigate the effects of propolis on hepatocytes. However, hepatoma cell lines, such as HepG2 cells, have previously been used [158,225,226], possibly owing to the ease of operation. After ligation of insulin and IR, IR β-chain (IRβ) is phosphorylated.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models

Kitamura

2019

Molecules

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Propolis is a natural product resulting from the mixing of bee secretions with botanical exudates. Since propolis is rich in flavonoids and cinnamic acid derivatives, the application of propolis extracts has been tried in therapies against cancer, inflammation, and metabolic diseases. As metabolic diseases develop relatively slowly in patients, the therapeutic effects of propolis in humans should be evaluated over long periods of time. Moreover, several factors such as medical history, genetic inheritance, and living environment should be taken into consideration in human studies. Animal models, especially mice and rats, have some advantages, as genetic and microbiological variables can be controlled. On the other hand, cellular models allow the investigation of detailed molecular events evoked by propolis and derivative compounds. Taking advantage of animal and cellular models, accumulating evidence suggests that propolis extracts have therapeutic effects on obesity by controlling adipogenesis, adipokine secretion, food intake, and energy expenditure. Studies in animal and cellular models have also indicated that propolis modulates oxidative stress, the accumulation of advanced glycation end products (AGEs), and adipose tissue inflammation, all of which contribute to insulin resistance or defects in insulin secretion. Consequently, propolis treatment may mitigate diabetic complications such as nephropathy, retinopathy, foot ulcers, and non-alcoholic fatty liver disease. This review describes the beneficial effects of propolis on metabolic disorders.

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Galangin and Pinocembrin from Propolis Ameliorate Insulin Resistance in HepG2 Cells via Regulating Akt/mTOR Signaling

Cited by 35 publications

References 38 publications

Antioxidant Activity and Phenolic Profile of Selected Organic and Conventional Honeys from Poland

Antioxidant Activity and Phenolic Profile of Selected Organic and Conventional Honeys from Poland

Advances in Biosynthesis, Pharmacology, and Pharmacokinetics of Pinocembrin, a Promising Natural Small-Molecule Drug

Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models

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