Galactosylated reduction and pH dual-responsive triblock terpolymer Gal-PEEP-a-PCL-ss-PDMAEMA: a multifunctional carrier for the targeted and simultaneous delivery of doxorubicin and DNA

Abstract

A multifunctional bioreducible system based on galactosamine-modified PEEP-a-PCL-ss-PDMAEMA has been prepared and used for the targeted co-delivery of doxorubicin and DNA.

Synthesis and micellization properties of triblock copolymers PDMAEMA-b-PCL-b-PDMAEMA and their applications in the fabrication of amphotericin B-loaded nanocontainers

“…Although researches recently show that polymer materials containing segments of PCL and PDMAEMA can be potentially used in drug delivery applications [13,15,[23][24][25][26][27][28], there is not a general consensus about the effect of their structure on their performance. The aim of this study is to establish relationships between the composition and molecular weight of triblock copolymers PDMAEMA-b-PCL-b-PDMAEMA with the colloidal properties of micelles obtained from their assembly in aqueous medium.…”

Synthesis and properties of antifouling poly(CL-co-zDMAEMA) zwitterionic copolymer by one-step hybrid copolymerization

“…5, both the cationic copolymer and the zwitterionic copolymer can form stable and uniform micelles of 100 nm in bR h N. And the bR h N of micelles decreases weakly with decreasing PDMAEMA segment. This is probably due to the fact that shorter PDMAEMA segments have a reduced solvation capacity and favor small aggregates [5]. By speculation and validation, copolymer P60 and P60S can disperse directly into the Milli-Q water and selfassemble into the micelles because of enough hydrophilic PDMAEMA segments.…”

“…Usually, the hydrophobic core of the micelles serves as a container for hydrophobic drugs, and the outer hydrophilic shell maintains a hydration barrier to provide colloidal stability. These polymer micelles with good compatibility and fine stability can enhance the aqueous solubility of drugs, reduce side effects, and improve the preferential accumulation at tumor sites by the enhanced permeability and retention (EPR) effect [2,4,5].…”

Tumour‐Targeted Drug Delivery with Mannose‐Functionalized Nanoparticles Self‐Assembled from Amphiphilic β‐Cyclodextrins

“…The drug release behaviour of DOX@C 3 ‐CD‐Man7 was investigated by measuring the fluorescence intensity at 590 nm ( λ ex =480 nm) with reference to a standard curve (Figure e) . PBS solutions of different pH were used as the external stimuli.…”

“…The drug releaseb ehaviour of DOX@C 3 -CD-Man7 wasi nvestigated by measuring the fluorescence intensity at 590 nm (l ex = 480 nm) with reference to astandard curve ( Figure 1e). [19] PBS solutions of different pH were used as the externals timuli. At physiological pH (7.4), only as mall amount of DOX was released from DOX@C 3 -CD-Man7 (less than 17 %) after 48 h. However,t he amount released increased rapidlyw hen DOX@C 3 -CD-Man7 was dispersed in acidic solution( pH 5.5), ultimately reaching approximately 52 %a fter 48 h. When PBS buffer (pH 3.5) was applied, the loaded DOX was released rapidly into the medium, eventually reaching approximately 90 %.…”