1987
DOI: 10.7164/antibiotics.40.122
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Galactostatin, a new .BETA.-galactosidase inhibitor from Streptomyces lydicus.

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Cited by 33 publications
(10 citation statements)
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“…The amino-sugar analog migalastat (galactostatin) was isolated as a fermentation product and is close in structure to nojirimycin ( 13a ) and galactose ( 13b ) . Because miglustat ( 13c ) was similar to the terminal galactose of the substrate for α-galactoside A, globotriasoylceramide, the natural product has been considered as a possible modulator of the enzyme .…”
Section: Case Studies: Drugs From Biological and Clinical Efforts (Re...mentioning
confidence: 99%
“…The amino-sugar analog migalastat (galactostatin) was isolated as a fermentation product and is close in structure to nojirimycin ( 13a ) and galactose ( 13b ) . Because miglustat ( 13c ) was similar to the terminal galactose of the substrate for α-galactoside A, globotriasoylceramide, the natural product has been considered as a possible modulator of the enzyme .…”
Section: Case Studies: Drugs From Biological and Clinical Efforts (Re...mentioning
confidence: 99%
“…This was given the trivial name of nojirimycin following structural characterisation after isolation from Streptomyces nojiriensis [37][38][39]. The finding of two related compounds nojirimycin B (2) and galactostatin (3) followed soon after [40,41]. The isolation and identifcation of iminosugars from plants proceeded these initial discoveries from micro-organisms, firstly with the monocyclic structures fagomine (4) and moranoline (5, deoxynojirimycin) followed by the isolation of bicyclic structures.…”
Section: Iminosugars: Classification Occurrence and Historical Contextmentioning
confidence: 99%
“…1-Deoxygalactonojirimycin (galactostatin, 11) a known powerful competitive inhibitor of plant -galactosidase [58][59][60], was examined as a candidate of chemical chaperon in the treatment of Fabry's disease ( Fig. 5) [61].…”
Section: Inhibitors Of Galactosidasesmentioning
confidence: 99%