Galactose-α-1,3-galactose syndrome: an Italian survey

Villalta, Danilo; Cecchi, Lorenzo; Farsi, Alessandro; Chiarini, Francesca; Minale, Paola; Voltolini, Susanna; Scala, Enrico; Quercia, O; Muratore, L.; Pravettoni, Valerio; Calamari, A; Cortellini, Gabriele; Asero, R

doi:10.23822/eurannaci.1764-1489.35

Cited by 13 publications

(12 citation statements)

References 19 publications

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“…Its pathogenesis is still elusive. Sensitization occurs after tick bites, of various species across the world, so that this form of allergy is frequent in rural areas and in summer months, during which the likelihood of being bitten by ticks is higher, and in susceptible patients, especially those with non-B blood groups, who are involved in outside activities [41] [42].…”

Section: The α-Gal Syndromementioning

confidence: 99%

Adult anaphylaxis: A state-of-the-art review

Rossi

Lenti

2022

European Journal of Internal Medicine

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Section: The α-Gal Syndromementioning

confidence: 99%

Adult anaphylaxis: A state-of-the-art review

Rossi

Lenti

2022

European Journal of Internal Medicine

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“…Serum specific IgE antibodies to the nonprimate mammalian epitope α-Gal are associated with the α-Gal syndrome: delayed allergy to the red meat manifested as late-onset anaphylaxis, urticaria or angioedema after ingestion of pig, beef or lamb meat, anaphylaxis with immediate onset at initial parenteral exposure to drugs significantly containing α-Gal, such as cetuximab [12,13,17,55]. Mechanisms for inducing IgE-mediated sensitization to α-Gal are complex.…”

Section: The α-Gal Syndromementioning

confidence: 99%

“…The assessment of CD63 + basophils induced by α-Gal and after stimulation with anti-FcεRI may be used to distinguish asymptomatic sensitization from α-Gal syndrome [32]. The most used diagnostic methods in the α-Gal syndrome are the intradermal test for cetuximab allergy and the detection of specific IgE against α-Gal for the allergy to red meat [55]. Implementing BAT beyond research poses some questions about reproducibility [58].…”

Section: Allergy Diagnosis For Drug Allergy In α-Gal Syndromementioning

confidence: 99%

DRUG ALLERGIES DUE TO IgE SENSITIZATION TO α-GAL

Popescu¹

2019

FARMACIA

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Serum specific IgE antibodies for non-primate mammalian carbohydrate galactose-α-1,3-galactose (α-Gal) are associated to α-Gal syndrome: delayed allergy to red meat manifested as anaphylaxis, angioedema or urticaria after ingestion of beef, pig or lamb meat, immediate-onset anaphylaxis at first parenteral exposure to drugs significantly containing α-Gal. IgE-mediated drug allergy in the α-Gal syndrome was reported for some therapeutic monoclonal antibodies, such as cetuximab, snake antivenom, and varicella-zoster vaccine, but there are risks also for colloid plasma volume substitutes, vaccines containing gelatine of porcine/bovine animal origin as an excipient, and drugs with porcine pancreatin or bovine-origin magnesium stearate. RezumatAnticorpii IgE specifici serici pentru carbohidratul galactoză-α-1,3-galactoză (α-Gal) al mamiferelor non-primate sunt asociați cu sindromul α-Gal: alergie tardivă la carnea roșie manifestată ca anafilaxie, angioedem sau urticarie după ingerarea de carne de vită, porc sau miel, anafilaxie imediată la prima expunere parenterală la medicamente care conțin în mod semnificativ α-Gal. Alergia mediată de IgE la medicamente în sindromul α-Gal a fost raportată pentru anumiți anticorpi monoclonali terapeutici, cum ar fi cetuximabul, antiveninul de șarpe și vaccinul varicelo-zosterian, dar există riscuri și pentru substituenții plasmatici coloidali de volum, vaccinuri care conțin gelatină de origine animală porcină/bovină ca excipient și medicamente cu pancreatină porcină sau stearat de magneziu de origine bovină.

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“…In Europe, the frequency of positivity of sIgE to α-Gal has been reported to be 5.5% in Denmark [17], 15.7% in a representative Spanish cohort [18] and 24.7% in a rural area in northeast Italy [19]. In the United States (U.S.), more than 5000 cases have been described [20].…”

Section: Introductionmentioning

confidence: 99%

The Quantification of IgG Specific to α-Gal Could Be Used as a Risk Marker for Suffering Mammalian Meat Allergy

Joral

Azketa

Sánchez

et al. 2022

Foods

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The alpha-Gal Syndrome is a delayed meat allergy characterized by the presence of sIgE against α-Gal epitope. It is known that the α-Gal present in tick saliva induces the sensitization to this epitope ending in the production of sIgG and sIgE to α-Gal. It could be considered that the more times a person is bitten by tick species, the higher the probability of making the switch from sIgG to sIgE to α-Gal and developing allergy, but it is no clear when the switch occurs. To determine the likelihood that a subject bitten by ticks but without AGS be at risk of developing this allergy, we quantified the levels of sIgG to α-Gal by an automated system (ImmunoCap). To stablish a cut-off value for sIgG to α-Gal, a receiving operating curve (ROC) was constructed. The statistical analysis demonstrated that the risk of suffering AGS in individuals bitten by ticks was 35% when the sIgG to α-Gal was greater than or equal to 40 µg/mL. Our data indicate that the sIgG values against α-Gal could be used as a prognostic marker for developing mammalian meat allergy.

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Galactose-α-1,3-galactose syndrome: an Italian survey

Cited by 13 publications

References 19 publications

Adult anaphylaxis: A state-of-the-art review

Adult anaphylaxis: A state-of-the-art review

DRUG ALLERGIES DUE TO IgE SENSITIZATION TO α-GAL

The Quantification of IgG Specific to α-Gal Could Be Used as a Risk Marker for Suffering Mammalian Meat Allergy

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