Galactography in Patients with Nipple Discharge

Lamont, Jeffrey P.; Dultz, R; Kuhn, Joseph A.; Grant, Michael D.; Jones, Ronald C.

doi:10.1080/08998280.2000.11927676

Cited by 16 publications

(10 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When ductography findings are positive, they have helped localize the intraductal lesions, increasing the diagnostic yield for surgical excision from 67% to 100%. 31 In our study, the sensitivity of ductography was similar to that previously reported (75%); however, the specificity was higher than previously reported values (72% in our study compared with 49% in the other reported studies). 18 This may be a consequence of stateof-the-art utilization of ductography by radiologists with five or more years of experience with ductography techniques.…”

Section: Discussionsupporting

confidence: 89%

“…Ductography is a nonspecific study since it cannot differentiate between benign and malignant lesions. When ductography findings are positive, they have helped localize the intraductal lesions, increasing the diagnostic yield for surgical excision from 67% to 100% . In our study, the sensitivity of ductography was similar to that previously reported (75%); however, the specificity was higher than previously reported values (72% in our study compared with 49% in the other reported studies) .…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Is Ductography Still Warranted in the 21st century?

et al. 2019

View full text Add to dashboard Cite

Objective To determine the utility of ductography in conjunction with mammography and ultrasound in patients with pathologic nipple discharge, and the incremental role of MRI after triple‐modality evaluation. Materials and Methods We retrospectively reviewed the medical records of patients who had presented with pathologic nipple discharge and had undergone mammography and/or ultrasound and ductography between January 1, 2005, and October 31, 2010. We tested the diagnostic sensitivity, specificity and accuracy of combined triple‐modality evaluation as well as of MRI performed in addition to these imaging techniques. We used the gold standard of image‐guided biopsies, surgical excision, or long‐term clinical and imaging follow‐up. Results Among 94 study patients, benign papillomas were identified in 42 (44.7%), abscess in one (1%), duct ectasia in four (4.3%), and malignancy (invasive ductal carcinoma or ductal carcinoma in situ) or high‐risk lesion (atypical ductal hyperplasia) in 10 (10.6%). Forty‐six patients (49%) underwent surgical excision; 89.1% of which had presurgical planning with ductography. In 35 (37.2%) with negative imaging, resolution of nipple discharge was confirmed on median clinical and imaging follow‐up of 36 months. Two patients with negative imaging were lost to follow‐up. Sensitivity, specificity, PPV, and NPV for accurately demonstrating the etiology of pathologic nipple discharge were 13%, 97%, 89%, and 37% respectively for mammography; 73%, 97%, 98%, and 64% respectively for ultrasound; 76%, 72%, 84%, and 61% respectively for ductography; 86%, 70%, 85%, and 72% respectively for combined ultrasound and ductography; and 75%, 100%, 100% and 67% respectively for DCE‐MRI. Conclusion The combination of mammography, ultrasound and ductography is highly accurate for identifying the etiology of pathologic nipple discharge. DCE‐MRI can be used as an alternate to ductography if necessary.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 88%

Is Ductography Still Warranted in the 21st century?

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The positive predictive value of ductography for malignancy has been reported as up to 19%, 32,33 but has been shown to improve the diagnostic yield of surgical excision from 67% to 100%. 34 The absence of an abnormality on ductography does not exclude malignancy, as the false-negative rate has been reported to be as high as 20%-30%. 32,33 In a review of 143 ductograms with histologic correlation, 5 normal ductograms were identified, 2 of which were found to have cancer, including one with calcifications in a quadrant other than the secreting duct, and one which was diagnosed by cytology.…”

Section: Clinical Significancementioning

confidence: 99%

Management of Nipple Discharge and the Associated Imaging Findings

Patel

Falcon

Drukteinis

2015

The American Journal of Medicine

View full text Add to dashboard Cite

“…In some cases, a discharge from the nipple is the only sign of carcinoma (12). A clear or watery discharge has been associated with breast cancer in up to 7% of cases (14).…”

Section: Causes Of Nipple Dischargementioning

confidence: 99%

MR Ductography: Comparison with Conventional Ductography as a Diagnostic Method in Patients with Nipple Discharge

Hirose¹,

Nobusawa²,

Gokan³

2007

RadioGraphics

View full text Add to dashboard Cite

Nipple discharge is a common symptom that mostly results from benign conditions. The most significant cause is carcinoma, which accounts for 1%-45% of cases. Therefore, identification of intraductal lesions is important. Conventional ductography, the recommended method of identifying lesions, is invasive and has inherent limitations. Magnetic resonance (MR) ductography is performed with heavily T2-weighted sequences; it is noninvasive and requires neither radiation nor contrast media. Like conventional ductography, MR ductography shows the dilated ducts as tubular structures with high signal intensity. Intraductal lesions appear as a signal defect, duct wall irregularity, or ductal obstruction. No specific conventional ductographic or MR ductographic finding allows differentiation between benign and malignant disease, and neither technique can demonstrate the extent of disease. MR mammography with intravenous injection of contrast material reveals the extent of disease, and a dynamic study may help distinguish between malignant and benign lesions. Fusion imaging with MR ductography and MR mammography demonstrates not only the presence of an intraductal abnormality but also the extent of the lesion on one image, thus clearly showing the relationship between the dilated duct and the intraductal lesion.

show abstract

Galactography in Patients with Nipple Discharge

Cited by 16 publications

References 17 publications

Is Ductography Still Warranted in the 21st century?

Is Ductography Still Warranted in the 21st century?

Management of Nipple Discharge and the Associated Imaging Findings

MR Ductography: Comparison with Conventional Ductography as a Diagnostic Method in Patients with Nipple Discharge

Contact Info

Product

Resources

About