Galactofuranose-rich polysaccharides from Trebouxia sp. induce inflammation and exacerbate lethality by sepsis in mice

Rattmann, Yanna Dantas; Malquevicz-Paiva, Simone M.; Iacomini, Marcello; Cordeiro, Lucimara M.C.

doi:10.1016/j.phytochem.2013.05.020

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…The lethality of CLP procedure was based on the percentage of deaths observed after surgery. The mortality rate found in our work was in accordance with previous studies with mice submitted to a similar CLP protocol (Rittirsch et al 2009;Rattmann et al 2013). These authors demonstrated that death rate 24 h after CLP was around 12% and 30% in C57BL/6 male mice submitted to a mid-and highgrade CLP model respectively (Rittirsch et al 2009).…”

Section: Discussionsupporting

confidence: 91%

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Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice

Ferreira

Santos

Bruxel

et al. 2017

Int J Experimental Path

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Sepsis is associated with high mortality. Both critically ill humans and animal models of sepsis exhibit changes in their glucose homeostasis, that is, hypoglycaemia, with the progression of infection. However, the relationship between basal glycaemia, glucose tolerance and insulin sensitivity is not well understood. Thus, we aimed to evaluate this glucose homeostasis triad at the late stage of sepsis (24 h after surgery) in male Swiss mice subjected to lethal and sublethal sepsis by the caecal ligation and puncture (CLP) model. The percentage of survival 24 h after CLP procedure in the Lethal and Sublethal groups was around 66% and 100% respectively. Both Lethal and Sublethal groups became hypoglycaemic in fasting and fed states 24 h after surgery. The pronounced fed hypoglycaemia in the Lethal group was not due to worsening anorexic behaviour or hepatic inability to deliver glucose in relation to the Sublethal group. Reduction in insulin sensitivity in CLP mice occurred in a lethality-dependent manner and was not associated with glucose intolerance. Analysis of oral and intraperitoneal glucose tolerance tests, as well as the gastrointestinal motility data, indicated that CLP mice had reduced intestinal glucose absorption. Altogether, we suggest cessation of appetite and intestinal glucose malabsorption are key contributors to the hypoglycaemic state observed during experimental severe sepsis.

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Section: Discussionsupporting

confidence: 91%

“…; Rattmann et al . ). These authors demonstrated that death rate 24 h after CLP was around 12% and 30% in C57BL/6 male mice submitted to a mid‐ and high‐grade CLP model respectively (Rittirsch et al .…”

Section: Discussionmentioning

confidence: 97%

Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice

Ferreira

Santos

Bruxel

et al. 2017

Int J Experimental Path

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“…Noteworthy is that Gal f is a five-membered ring sugar that is mainly found on the surface of many pathogenic species such as Mycobacterium tuberculosis , Aspergillus and Leishmania species 5 , 6 . The peculiarity of this sugar arises from its high immunogenicity 7 , 8 and the fact that it is totally absent from mammals 5 . The detection of Gal f can therefore be of interest for diagnosis of infection 9 , 10 .…”

Section: Introductionmentioning

confidence: 99%

The LPG1x family from Leishmania major is constituted of rare eukaryotic galactofuranosyltransferases with unprecedented catalytic properties

Ati

Colas

Lafite

et al. 2018

Sci Rep

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Galactofuranosyltransferases are poorly described enzymes despite their crucial role in the virulence and the pathogenicity of numerous microorganisms. These enzymes are considered as potential targets for therapeutic action. In addition to the only well-characterised prokaryotic GlfT2 from Mycobacterium tuberculosis, four putative genes in Leishmania major were previously described as potential galactofuranosyltransferases. In this study, we have cloned, over-expressed, purified and fully determined the kinetic parameters of these four eukaryotic enzymes, thus demonstrating their unique potency in catalysing the transfer of the galactofuranosyl moiety into acceptors. Their individual promiscuity revealed to be different, as some of them could efficiently use NDP-pyranoses as donor substrates in addition to the natural UDP-galactofuranose. Such results pave the way for the development of chemoenzymatic synthesis of furanosyl-containing glycoconjugates as well as the design of improved drugs against leishmaniasis.

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Cannabinoid CB1 Receptor Antagonist Rimonabant Decreases Levels of Markers of Organ Dysfunction and Alters Vascular Reactivity in Aortic Vessels in Late Sepsis in Rats

et al. 2018

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Galactofuranose-rich polysaccharides from Trebouxia sp. induce inflammation and exacerbate lethality by sepsis in mice

Cited by 4 publications

References 40 publications

Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice

Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice

The LPG1x family from Leishmania major is constituted of rare eukaryotic galactofuranosyltransferases with unprecedented catalytic properties

Cannabinoid CB1 Receptor Antagonist Rimonabant Decreases Levels of Markers of Organ Dysfunction and Alters Vascular Reactivity in Aortic Vessels in Late Sepsis in Rats

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