Galactia lindenii lectin type-II. Proposal of its potential use in diagnostic tools

Abstract

Galactia lindenii lectin type-II (GLL-II) belongs to the group of the legume lectins. The present study investigated the GLL-II staining patterns in histological sections of neoplastic and non-neoplastic thyroid tissues. Besides, hemagglutination assays (HA) using the GLL-II on red blood cells (RBCs) of different glycomic profile were performed, complementing previous results. The differential staining in Papillary Thyroid Cancer (PTC), Invasive Encapsulated Follicular Variant Papillary Thyroid Carcinoma (IEFV-PTC), Hashimoto's thyroiditis (HT), and non-neoplastic thyroid with goiter changes, together with the HA results and along with reviewed glycoprofiles of unhealthy conditions in other organs, allowed us to propose the potential utility of GLL-II in lectin platforms used to discriminate human pathological samples from normal ones. The present study shed light on potential applications of GLL-II in determining alterations of glycosylation patterns in specific cells, tissues, or body fluids, as well as glycotopes biomarkers of healthy or pathological conditions.