Gait subgroups among older adults with chronic pain differ in cerebellum and basal ganglia gray matter volumes

Lipat, Ania L.; Clark, David J.; Hass, Chris J.; Cruz-Almeida, Yenisel

doi:10.1016/j.exger.2022.111773

Cited by 6 publications

(1 citation statement)

References 46 publications

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“…The abovementioned studies focused on gait and balance treatment, whereas we trained the upper limbs exclusively. In contrast to gait [ 50 , 51 , 52 ], during upper limb movements, prevalent cerebral activation occurs in the cortical areas (i.e., sensorimotor cortex, supplementary motor area, premotor cortex, inferior frontal gyrus and ipsilateral anterior cingulate) both in neurological patients and healthy controls [ 53 , 54 ]. Motor exercise may increase the production of growth factors and promote gray and white matter changes, especially in the prefrontal region, with a particular effect on executive functions [ 55 , 56 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Upper Limb Motor Rehabilitation on Cognition in Parkinson’s Disease: An Observational Study

et al. 2022

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Parkinson’s disease is characterized by motor and cognitive deficits that usually have an impact on quality of life and independence. To reduce impairment, various rehabilitation programs have been proposed, but their effects on both cognitive and motor aspects have not been systematically investigated. Furthermore, most intervention is focused on lower limb treatment rather than upper limbs. In the present study, we investigated the effect of 3-week upper limb vibratory stimulation training on cognitive functioning in 20 individuals with Parkinson’s disease. We analyzed cognitive (Montreal Cognitive Assessment, Trial Making Test, Digit Symbol, Digit Span Forward and Backward and Alertness) and motor performance (Unified Parkinson’s Disease Rating Scale—part III; Disability of the Arm, Shoulder and Hand Questionnaire) before treatment, at the end of treatment and one month post treatment. After rehabilitation, a statistically significant improvement was observed in terms of global cognitive status, attention, global motor functioning and disability. The results suggest an impact of upper limb motor rehabilitation on cognition in Parkinson’s disease. Future studies on neuromotor interventions should investigate their effects on cognitive functioning to improve understanding of cognitive motor interaction in Parkinson’s disease.

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