Gait in children with infantile/atypical autism: Age-dependent decrease in gait variability and associations with motor skills

Manicolo, Olivia; Brotzmann, Mark; Arx, Priska Hagmann-von; Grob, Alexander; Weber, Peter

doi:10.1016/j.ejpn.2018.09.011

Cited by 37 publications

(33 citation statements)

References 55 publications

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“…To date, most studies have been carried out in children and adolescents, leaving quantitative movement experiments in autistic adults an understudied area. Combined with results that indicate an age-dependent decrease of motor impairments (Manicolo et al, 2019;Minshew et al, 2004), this justifies the question of whether motor impairments are persistent throughout the lifespan of autistic people. Here, we investigated whole-body movements in a quantitative manner using motion capture technology, comparing neutral walking in autistic and TD adults.…”

Section: Movement Impairments In Asdmentioning

confidence: 83%

“…Our data show no reduction in acceleration or velocity when comparing ASD and TD walking data. Reduced walking speed was found in ASD by few studies (Ambrosini et al, 1998;Armitano et al, 2020;Morrison et al, 2018;Weiss et al, 2013), but several others reported no quantitative differences between ASD and TD (Biffi et al, 2018;Calhoun et al, 2011;Chester & Calhoun, 2012;Hallett et al, 1993;Manicolo et al, 2019;Nayate et al, 2012;Vernazza-Martin et al, 2005). Our results corroborate the findings of the majority of studies on walking speed in ASD.…”

Section: Discussion Experiments One: Gaitmentioning

confidence: 98%

“…Other findings include differences in postural control (Minshew et al, 2004), slower armmovements in goal-directed tasks (Stoit et al, 2013), and abnormal fine motor control (handwriting) with associated atypical biomechanical strategies (Johnson et al, 2013) Some researchers proposed body movement impairments to be a fundamental aspect of ASD and a potential biomarker for diagnosis (Cook et al, 2013;Donnellan et al, 2013;Fournier et al, 2010;Leary & Hill, 1996;Parma & de Marchena, 2015;Teitelbaum et al, 1998). However, the results of studies across the lifespan and across the range of autism as a spectrum are equivocal (Biffi et al, 2018;Chester & Calhoun, 2012;Hallett et al, 1993;Manicolo et al, 2019;).…”

Section: Movement Impairments In Asdmentioning

confidence: 99%

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Quantitative Analysis of Motor Behavior in Adults with High Functioning Autism Spectrum Disorder

Lammers¹

2020

Preprint

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Autism spectrum disorder (ASD) is an umbrella term for a range of conditions that share core symptoms such as restricted interests, repetitive behaviors and deficits in social interaction and communication. Motor impairments in ASD have been investigated mainly in children and adolescents. Although the results are equivocal, some researchers proposed motor impairments to be a core symptom of ASD. Research in adults with ASD remains scarce, but existing evidence suggests that an age-related decrease in motor symptoms is likely. In addition, the level of functioning may have an influence on motor skills. In the current project, motion capture technology was used to quantify motor behavior of adults with and without high functioning ASD. Participants were recorded (1) while performing neutral walking movements, and (2) while performing mood-influenced everyday activities. The results show no significant differences in walking movements between participants with or without ASD. In contrast, the results of the mood-influenced movements show significant group differences. Together, these results suggest that general motor skills in adults with high functioning ASD are not impaired, while the production of nonverbal bodily cues is significantly different. These bodily cues carry information (e.g. about mood) that are relevant for nonverbal communication. It has been shown that the recognition of perceived movements increases when movements are more similar to the movements of the perceiver. The current results thus show that the difficulties in nonverbal communication between persons with and without ASD may stem from differences in movement profiles.

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Section: Movement Impairments In Asdmentioning

confidence: 83%

Section: Discussion Experiments One: Gaitmentioning

confidence: 98%

Section: Movement Impairments In Asdmentioning

confidence: 99%

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Quantitative Analysis of Motor Behavior in Adults with High Functioning Autism Spectrum Disorder

Lammers¹

2020

Preprint

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“…A seguir serão apresentados os estudos encontrados que exibiram hipótese nula, mas que também apresentam grande contribuição para a dialeticidade científica. Manicolo et al (2019) relata que crianças com TEA apresentaram maior variabilidade da marcha do que as crianças dos grupos controle, indicando sim um padrão de caminhada menos regular, mas essa questão não pode ser associada a marcos motores antes da caminhada. A maior variabilidade da marcha em crianças com TEA mostraram uma diminuição dependente da idade, sugerindo que a regularidade da marcha converge para a de crianças em desenvolvimento típico.…”

Section: Discussionunclassified

O desenvolvimento motor e a aquisição de habilidades motoras em autistas

Vito

Santos²

2020

POBS

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O desenvolvimento motor e as habilidades motoras em crianças autistas ainda permanecem pouco compreendidas. Estudos sugerem fortes relações entre o transtorno do espectro autista (TEA) com déficits do desenvolvimento motor e a aquisição de habilidades motoras, mas apesar disso, ainda hoje, essa questão não é considerada como critério diagnóstico. Fator intrigante entre os pesquisadores da área. A presente pesquisa realizou uma Revisão Integrativa da Literatura (RIL), com o objetivo de relacionar estudos sobre o desenvolvimento motor e a aquisição das habilidades motoras em crianças com TEA quando comparadas com crianças típicas. A pesquisa foi relizada na base de dados do Pub Med, através dos descritores “autismo” e “desenvolvimento motor” e “habilidades motoras”, após a aplicação dos critérios de inclusão e exclusão foram selecionados quinze artigos para análise. Os estudos incluídos apresentam um consenso razoável sobre a existência de atrasos motores em crianças com TEA, contudo em sua quase unanimidade, apontam para a necessidade de pesquisas mais aprofundadas por motivos diversos, seja pelo baixo número de participantes ou pelas dificuldades de isolar as caracterísitcas autísticas, em seus diferentes níveis.

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“…Early attainment is associated with better cognitive outcomes in adulthood, such as higher education, better executive function, and a higher level of intelligence [ 9 ]. Furthermore, it has been shown that delayed motor development associates with psychopathological disorders such as schizophrenia, autism and neurosis [ 7 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Delayed Motor Milestones Achievement in Infancy Associates with Perturbations of Amino Acids and Lipid Metabolic Pathways

et al. 2020

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The relationship between developmental milestone achievement in infancy and later cognitive function and mental health is well established, but underlying biochemical mechanisms are poorly described. Our study aims to discover pathways connected to motor milestone achievement during infancy by using untargeted plasma metabolomic profiles from 571 six-month-old children in connection with age of motor milestones achievement (Denver Developmental Index) in the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother–child cohort. We used univariate regression models and multivariate modelling (Partial Least Squares Discriminant Analysis: PLS-DA) to examine the associations and the VDAART (Vitamin D Antenatal Asthma Reduction Trial) cohort for validation. The univariate analyses showed 62 metabolites associated with gross-motor milestone achievement (p < 0.05) as well as the PLS-DA significantly differentiated between slow and fast milestone achievers (AUC = 0.87, p = 0.01). Higher levels of tyramine-O-sulfate in the tyrosine pathway were found in the late achievers in COPSAC (p = 0.0002) and in VDAART (p = 0.02). Furthermore, we observed that slow achievers were characterized by higher levels of fatty acids and products of fatty acids metabolism including acyl carnitines. Finally, we also observed changes in the lysine, histidine, glutamate, creatine and tryptophan pathways. Observing these metabolic changes in relation to gross-motor milestones in the first year of life, may be of importance for later cognitive function and mental health.

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Gait in children with infantile/atypical autism: Age-dependent decrease in gait variability and associations with motor skills

Cited by 37 publications

References 55 publications

Quantitative Analysis of Motor Behavior in Adults with High Functioning Autism Spectrum Disorder

Quantitative Analysis of Motor Behavior in Adults with High Functioning Autism Spectrum Disorder

O desenvolvimento motor e a aquisição de habilidades motoras em autistas

Delayed Motor Milestones Achievement in Infancy Associates with Perturbations of Amino Acids and Lipid Metabolic Pathways

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