Gait analysis in rats with peripheral nerve injury

Yu, Peirong; Matloub, Hani S.; Sanger, James R.; Narini, P

doi:10.1002/1097-4598(200102)24:2<231::aid-mus80>3.0.co;2-5

Cited by 74 publications

(54 citation statements)

References 17 publications

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“…In contrast, the swing phase duration remained unaffected by walking speed (R 2 = 0.119 for left leg and R 2 = 0.176 for right leg). Consistent with previous findings (Yu et al, 2001), the step length ratio (SLR) found to be independent of the walking speed (p-value = 0.25).…”

Section: Gait Parameterssupporting

confidence: 91%

“…The experimental setup was adapted from the design by Yu et al (2001). Animals were videotaped while spontaneously walking inside a Plexiglas chamber towards a darkened goal box.…”

Section: Gait Analysismentioning

confidence: 99%

“…Regardless, novel objective techniques are needed to quantify the dystonias and provide sensitive measures to detect subtle forms of the movement disorder . Gait analysis has been used extensively to quantify experimental spinal cord injuries (Cheng et al, 1997;Metz et al, 2000), peripheral neuropathy (Yu et al, 2001) and Parkinson disease (Amende et al, 2005) in rodent models. In these studies, quantitative aspects of gait have been assessed from video recordings of freely moving animals.…”

Section: Introductionmentioning

confidence: 99%

“…Stance to Swing ratio (SSR): Duration of the stance and the swing phases were determined by analyzing the videos on a frame by frame basis. The stance to swing ratio (SSR) was obtained by dividing the right stance/swing ratio with that of the left (Yu et al, 2001).…”

mentioning

confidence: 99%

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Quantification of gait in dystonic Gunn rats

Chaniary

Baron

Rice

et al. 2009

Journal of Neuroscience Methods

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Section: Gait Parameterssupporting

confidence: 91%

“…The experimental setup was adapted from the design by Yu et al (2001). Animals were videotaped while spontaneously walking inside a Plexiglas chamber towards a darkened goal box.…”

Section: Gait Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Quantification of gait in dystonic Gunn rats

Chaniary

Baron

Rice

et al. 2009

Journal of Neuroscience Methods

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“…67 Other gait parameters have therefore been investigated, including analysis of the ankle angle. 36,57,64,65,72 An advantage of ankle motion analysis is that it can also be used to investigate the accuracy of reinnervation of muscles involved in ankle plantar (tibial nerve function) and dorsiflexion (peroneal nerve function), 14 especially if used simultaneously with electromyography recordings in the tibialis anterior and gastrocnemius muscles. 27 We have used digital video analysis to investigate the recovery of ankle motion after different types of sciatic nerve injury and repair (crush injury, direct coaptation, and autograft repair).…”

Section: Motion Analysismentioning

confidence: 99%

Misdirection and guidance of regenerating axons after experimental nerve injury and repair

Ruiter

Spinner

Verhaagen

et al. 2014

JNS

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Misdirection of regenerating axons is one of the factors that can explain the limited results often found after nerve injury and repair. In the repair of mixed nerves innervating different distal targets (skin and muscle), misdirection may, for example, lead to motor axons projecting toward skin, and vice versa-that is, sensory axons projecting toward muscle. In the repair of motor nerves innervating different distal targets, misdirection may result in reinnervation of the wrong target muscle, which might function antagonistically. In sensory nerve repair, misdirection might give an increased perceptual territory. After median nerve repair, for example, this might lead to a dysfunctional hand.Different factors may be involved in the misdirection of regenerating axons, and there may be various mechanisms that can later correct for misdirection. In this review the authors discuss these different factors and mechanisms that act along the pathway of the regenerating axon. The authors review recently developed evaluation methods that can be used to investigate the accuracy of regeneration after nerve injury and repair (including the use of transgenic fluorescent mice, retrograde tracing techniques, and motion analysis). In addition, the authors discuss new strategies that can improve in vivo guidance of regenerating axons (including physical guidance with multichannel nerve tubes and biological guidance accomplished using gene therapy). 493Abbreviations used in this paper: BDNF = brain-derived neurotrophic factor; DY = diamidino yellow; FB = fast blue; GC = growth cone; GDNF = glial cell line-derived neurotrophic factor; LV = lentiviral vector; NGF = nerve growth factor.

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Sticky and Strain‐Gradient Artificial Epineurium for Sutureless Nerve Repair in Rodents and Nonhuman Primates

Seong,

Choi,

Choi

et al. 2024

Advanced Materials

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The need for the development of soft materials capable of stably adhering to nerve tissues without any suturing followed by additional damages has been at the fore at a time when success in postoperative recovery depends largely on the surgical experience and/or specialized microsuturing skills of the surgeon. Despite fully recognizing such prerequisite conditions, designing the materials with robust adhesion to wet nerves as well as acute/chronic anti‐inflammation remains to be resolved. Herein, we present a sticky and strain‐gradient artificial epineurium (SSGAE) that overcomes the most critically challenging aspect for realizing sutureless repair of severely injured nerves. In this regard, the SSGAE with a skin‐inspired hierarchical structure entailing strain‐gradient layers, anisotropic Janus layers including hydrophobic top and hydrophilic bottom surfaces, and synergistic self‐healing capabilities enables immediate and stable neurorrhaphy in both rodent and nonhuman primate models, indicating that our bioinspired materials strategy significantly contributes to translational medicine for effective peripheral nerve repair.This article is protected by copyright. All rights reserved

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Gait analysis in rats with peripheral nerve injury

Cited by 74 publications

References 17 publications

Quantification of gait in dystonic Gunn rats

Quantification of gait in dystonic Gunn rats

Misdirection and guidance of regenerating axons after experimental nerve injury and repair

Sticky and Strain‐Gradient Artificial Epineurium for Sutureless Nerve Repair in Rodents and Nonhuman Primates

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