Gait analysis and knee joint kinematics before a and 6 month after of corrective valgus osteotomy at patients with medial knee arthritis

Skvortsov, Dmitry; Kaurkin, Sergey N.; Prizov, A. P.; Altukhova, Alyona; Goncharov, Evgeniy; Nikitin, Artem

doi:10.1007/s00264-022-05370-9

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…It is a common and validated technique for painful medial compartmental OA of the knee with varus deformity, primarily for relatively young and active patients, producing good results with fewer drawbacks than other techniques in short-and mid-term follow-up [18]. In addition to the clinical improvement of the knee joint, determined by pain reduction, high tibial osteotomy (HTO) permits the restoration of normal gait biomechanics, as observed in our previous studies [19,20]. Furthermore, recent studies have demonstrated that HTO efficacy is increased when various post-treatments are applied [21].…”

Section: Introductionmentioning

confidence: 96%

Long-Term Structural Changes in the Osteochondral Unit in Patients with Osteoarthritis Undergoing Corrective Osteotomy with Platelet-Rich Plasma or Stromal Vascular Fraction Post-Treatment

Prizov,

Tchetina,

Volkov

et al. 2024

Biomedicines

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This pilot study examined the long-term structural changes in the osteochondral unit of 20 patients with knee osteoarthritis (KOA) who underwent high tibial osteotomy (HTO) and received post-treatment with either platelet-rich plasma (PRP) or stromal vascular fraction (SVF). Ten patients were injected with autologous PRP (PRP subgroup), while another ten patients received autologous SVF (SVF subgroup) six weeks after surgery and were monitored for 18 months. Histological samples of bone and cartilage (2 mm in diameter and 2 cm long) were taken from tibial and femoral sites during surgery and 18-month post-HTO, and morphometric analyses were conducted using Mega-Morf12 software. Both post-treatment resulted in an increase in articular cartilage height at both sites (p < 0.001 in the tibia and femur), indicating positive outcomes. Significant improvements in subchondral and trabecular bone architecture were also observed, with SVF injection showing higher reparative capacity in terms of bone volume (p < 0.001 for the tibia and p = 0.004 for the femur), subchondral bone height (p < 0.001 for the tibia and p = 0.014 for the femur), trabecular bone volume (p < 0.001 for the femur), and intertrabecular space (p = 0.009 for the tibia and p = 0.007 for the femur). This pilot study, for the first time, demonstrates that HTO surgery combined with PRP and SVF post-treatments can lead to significant enhancements in knee articular cartilage and bone architecture in KOA patients, with SVF showing higher regenerative potential. These findings may contribute to improving treatment strategies for better clinical outcomes in HTO therapy for patients with KOA.

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Section: Introductionmentioning

confidence: 96%

Long-Term Structural Changes in the Osteochondral Unit in Patients with Osteoarthritis Undergoing Corrective Osteotomy with Platelet-Rich Plasma or Stromal Vascular Fraction Post-Treatment

Prizov,

Tchetina,

Volkov

et al. 2024

Biomedicines

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“…It is a complex disorder involving the entire joint, with changes occurring in the synovial fluid, underlying bone, ligaments, and surrounding muscles. While it has traditionally been viewed as a wear-and-tear disease, modern understanding acknowledges that inflammatory processes play a crucial role in its progression [3].…”

Section: Introductionmentioning

confidence: 99%

Stromal Vascular Fraction Therapy for Knee Osteoarthritis: A Systematic Review

Goncharov,

Koval,

Nikolaevich Bezuglov

et al. 2023

Medicina

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Background and Objectives: Knee osteoarthritis (OA) is a widespread joint disease, set to increase due to aging and rising obesity. Beyond cartilage degeneration, OA involves the entire joint, including the synovial fluid, bones, and surrounding muscles. Existing treatments, such as NSAIDs and corticosteroid injections, mainly alleviate symptoms but can have complications. Joint replacement surgeries are definitive but carry surgical risks and are not suitable for all. Stromal vascular fraction (SVF) therapy is a regenerative approach using cells from a patient’s adipose tissue. SVF addresses as degenerative and inflammatory aspects, with potential for cartilage formation and tissue regeneration. Unlike traditional treatments, SVF may reverse OA changes. Being autologous, it reduces immunogenic risks. Materials and Methods: A systematic search was undertaken across PubMed, Medline, and Scopus for relevant studies published from 2017 to 2023. Keywords included “SVF”, “Knee Osteoarthritis”, and “Regenerative Medicine”. Results: This systematic search yielded a total of 172 articles. After the removal of duplicates and an initial title and abstract screening, 94 full-text articles were assessed for eligibility. Of these, 22 studies met the inclusion criteria and were subsequently included in this review. Conclusions: This review of SVF therapy for knee OA suggests its potential therapeutic benefits. Most studies confirmed its safety and efficacy, and showed improved clinical outcomes and minimal adverse events. However, differences in study designs and sizes require a careful interpretation of the results. While evidence supports SVF’s positive effects, understanding methodological limitations is key. Incorporating SVF is promising, but the approach should prioritize patient safety and rigorous research.

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Effect of floor and chair sit-to-stand motions on determination of optimal surgical site for anterior cruciate ligament reconstruction surgery

Cho,

Han,

Bae

2024

J Mech Sci Technol

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Gait analysis and knee joint kinematics before a and 6 month after of corrective valgus osteotomy at patients with medial knee arthritis

Cited by 5 publications

References 31 publications

Long-Term Structural Changes in the Osteochondral Unit in Patients with Osteoarthritis Undergoing Corrective Osteotomy with Platelet-Rich Plasma or Stromal Vascular Fraction Post-Treatment

Long-Term Structural Changes in the Osteochondral Unit in Patients with Osteoarthritis Undergoing Corrective Osteotomy with Platelet-Rich Plasma or Stromal Vascular Fraction Post-Treatment

Stromal Vascular Fraction Therapy for Knee Osteoarthritis: A Systematic Review

Effect of floor and chair sit-to-stand motions on determination of optimal surgical site for anterior cruciate ligament reconstruction surgery

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