2018
DOI: 10.14336/ad.2017.0925
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Gait Analyses in Mice: Effects of Age and Glutathione Deficiency

Abstract: Minor changes (~0.1 m/s) in human gait speed are predictive of various measures of decline and can be used to identify at-risk individuals prior to further decline. These associations are possible due to an abundance of human clinical research. However, age-related gait changes are not well defined in rodents, even though rodents are used as the primary pre-clinical model for many disease states as well as aging research. Our study investigated the usefulness of a novel automated system, the CatWalk™ XT, to me… Show more

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Cited by 12 publications
(13 citation statements)
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“…This might be ascribed to the particularly stressful MWM conditions, lowering its inter-individual sensitivity for aged animals [54,55]. Our CatWalk analysis also supports verapamil's rejuvenating effect on senile sensorimotor abnormalities while adding further information to the existing knowledge on age-related gait changes in preclinical rodent models [56].…”
Section: Discussionsupporting
confidence: 66%
“…This might be ascribed to the particularly stressful MWM conditions, lowering its inter-individual sensitivity for aged animals [54,55]. Our CatWalk analysis also supports verapamil's rejuvenating effect on senile sensorimotor abnormalities while adding further information to the existing knowledge on age-related gait changes in preclinical rodent models [56].…”
Section: Discussionsupporting
confidence: 66%
“…Prior studies focused on male mice ( Bair et al, 2019 ; Tarantini et al, 2019 ) or combined cohorts ( Zhang et al, 2014 ). One study in which male and female mice in different age groups were compared did not reveal sex differences in average speed, cycle duration (sum of swing time and stance time), base or swing speed, but that study did not have a longitudinal design and mice were being followed up to old age only (17 months; Mock et al, 2018 ). Furthermore, the latter study did not control for changes in speed, as discussed above.…”
Section: Discussionmentioning
confidence: 99%
“…To separate changes in walking style from a decline in gait speed alone, measurements of spatial and temporal gait metrics can be helpful ( Wilson et al, 2019 ). While there are many valid methods to capture gait metrics in human or animal models, the challenge lies in the interpretation of changes in gait metrics in the setting of declining speed: key gait metrics that dictate speed, i.e., stride length, stance time and swing time and their derivatives, change as a function of speed and do so independently ( Figure 1 ; Broom et al, 2017 ; Mock et al, 2018 ). This problem is further magnified when datasets are averaged.…”
Section: Introductionmentioning
confidence: 99%
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