Gaining Insights Into the Relationship of Obesity, Weight Loss, and Psoriasis

Cardiometabolic Comorbidities in Patients With Psoriasis: Focusing on Risk, Biological Therapy, and Pathogenesis

“…A recent meta-analysis of prospective studies showed that the relative risk of the relevance between psoriasis risk and per 5-unit increment in body mass index (BMI), per 10-cm increment in waist circumference, per 0.1-unit increment in the waist-to-hip ratio , per 5 kg of weight gain was 1.19 (95% CI: 1.10–1.28), 1.24 (95% CI: 1.17–1.31), 1.37 (95% CI: 1.23–1.53), and 1.11 (95% CI: 1.07–1.16), respectively, concluding that risk of psoriasis increases with the degree of obesity measured by the four abovementioned aspects ( Aune et al, 2018 ). As the severity of psoriasis has a positive correlation with weight gain, several studies investigated the impact of weight loss on psoriasis severity through low-energy diet or bariatric surgery ( Jensen et al, 2013 ; Shelling and Kirsner, 2013 ; Debbaneh et al, 2014 ). They found that weight loss in overweight patients with psoriasis showed a declined trend of psoriasis severity manifested as a reduction of PASI and improved quality of life ( Jensen et al, 2013 ; Shelling and Kirsner, 2013 ; Debbaneh et al, 2014 ).…”

“…As the severity of psoriasis has a positive correlation with weight gain, several studies investigated the impact of weight loss on psoriasis severity through low-energy diet or bariatric surgery ( Jensen et al, 2013 ; Shelling and Kirsner, 2013 ; Debbaneh et al, 2014 ). They found that weight loss in overweight patients with psoriasis showed a declined trend of psoriasis severity manifested as a reduction of PASI and improved quality of life ( Jensen et al, 2013 ; Shelling and Kirsner, 2013 ; Debbaneh et al, 2014 ). It is possible that psoriasis might develop first and bring about obesity.…”

Study Protocol: Role of Intermittent Fasting on Disease Severity and Quality of Life in Psoriasis and Psoriatic Arthritis: A Single-Blind Parallel Group Randomized Control Trial

“…1,2,4,5 Increased body mass index (BMI) is associated with increased risk of new-onset psoriasis, and higher BMIs are associated with increased severity of psoriasis at onset, measured by Psoriasis Area and Severity Index (PASI). 6 An additional cross-sectional study showed that the PASI score was positively correlated with all three measures of weight, including BMI, waist circumference, and waist-to-hip ratio. 7 It has been suggested that a component of the improved PASI score seen with weight loss is due to the higher relative dosing of systemic therapies.…”

“…7 It has been suggested that a component of the improved PASI score seen with weight loss is due to the higher relative dosing of systemic therapies. 6 Based on a 2018 study published for the National Psoriasis Foundation Medical Board, several dietary recommendations were developed using data from 55 distinct research studies. 1 First, the foundation concluded that dietary weight reduction is beneficial for patients with psoriasis who are overweight.…”

“…While caloric restriction and IF produce similar reduction in weight and improved insulin sensitivity, IF offers additional anti-inflammatory benefits, reduced oxidative stress, and circadian rhythm synchrony, which are advantageous for inflammatory conditions, such as psoriasis. 6,8,14 The pathophysiology behind the influence of dietary interventions in dermatology is complex. Increased levels of keystone pro-inflammatory cytokines implicated in psoriasis, IL-17, IL-23, IL-6 and TNF-α, are also seen at elevated levels in patients who are obese.…”