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Plants do not grow in isolation, rather they are also hosts to a variety of microbes in their natural
environments. While, few thrive in the plants for their sole benefit, others may have a direct bearing on
plants in a symbiotic manner. Unravelling plant-microbe interactions is a crucial component to
recognize the beneficial and detrimental impact of microbes on plants. Also, by affecting the
environment around plants, microbes may indirectly influence the plants. The progress in sequencing
technologies in the genomics era and several omics tool has grown in biological science. Studying the
complex nature of plant-microbe interactions can offer several strategies to increase productivity of
plants in an environmentally friendly manner by providing better insights. This review brings forward
the recent works performed in building omics strategies that decipher the interactions between plantmicrobiome. At the same time, this study further explores other associated mutually beneficial aspects
of plant-microbe interactions such as plant growth promotion, nitrogen fixation, stress suppressions in
crops and bioremediation. This work also provides a better intelligence about metabolic interactions
between the microbe and the plant through omics approaches. The review explores advances in the
study of Arabidopsis as an important avenue to serve as a baseline tool to create models that help in
scrutinizing various factors that contribute to the elaborate relationship between the plant and microbes.
Causal relationships between plants and microbes can be established through systematic gnotobiotic
experimental studies to test hypotheses on biologically derived interactions. This review will bring forth
recent advances in the study of plant-microbe interactions keeping in view the advantages of these
interactions in improving nutrient uptake and plant health.