“…Across nearly all cancers, including those affecting children, adolescents, and young adults, XPO1 is expressed ( Figure 1 ) [ 52 , 53 , 54 , 55 , 56 , 57 , 58 ], and higher expression has been correlated with inferior outcome. XPO1 is located on chromosome arm 2p, a region frequently associated with somatic copy number changes in cancer (e.g., gastric cancer, CLL, lymphomas, neuroblastoma, and rhabdomyosarcoma), and a region that includes putative proto-oncogenes N-MYC , REL , and BCL11A [ 7 , 59 , 60 , 61 , 62 ]. This region may be key to understanding how XPO1 regulation is coopted to promote oncogenesis and to distinguish between sufficiency and necessity of overexpression to promote aggressive disease.…”