Gag-Specific Cytotoxic T-Lymphocyte-Based Control of Primary Simian Immunodeficiency Virus Replication in a Vaccine Trial

Abstract

Gag-specific cytotoxic T lymphocytes (CTLs

Evaluation of humoral, mucosal, and cellular immune responses following co-immunization of HIV-1 Gag and Env proteins expressed by Newcastle disease virus

“…[19][20][21] Vaccine trials in non-human primates have also shown an association between Gag-specific cell mediated responses and virologic control in vaccinated monkeys following SIV challenge. 7,22,23 Newcastle disease virus (NDV), a member of the genus Avulavirus in the family Paramyxoviridae, has a number of characteristics that make it useful as a vaccine vector in humans. A wide range of NDV strains exist that can be used as vectors.…”

Characterization of T-Cell Responses in Macaques Immunized with a Single Dose of HIV DNA Vaccine

“…Nevertheless, studies of the nature of protective responses against HIV and SIV indicated that the magnitude and breadth of CD8 ϩ T-cell responses to Gag and other HIV antigens correlate with the control of virus replication (26,28,65). Using first the mouse model, we reported that a single-dose injection of ⌬4SHIV KU2 induced long-lasting and polyfunctional CD8 ϩ T-cell responses against all HIV antigens with substantial responses toward Gag (5).…”

HIV-1 Tat-Based Vaccines: An Overview and Perspectives in the Field of HIV/AIDS Vaccine Development

“…[63][64][65][66][67]. These strategies based on recombinant proteins, DNA plasmids, or expression vectors have proven to be effective in controlling viremia and progression to AIDS in non-human primates [68][69][70][71][72][73][74][75]. Nevertheless, evidence indicates that the targeting of T-cell responses on immunodominant epitopes can facilitate the insurgence of viral mutants that escape the vaccineinduced immune control [76,77].…”