GAG mimetic functionalised solid and mesoporous silica nanoparticles as viral entry inhibitors of herpes simplex type 1 and type 2 viruses

Lee, Edward C.; Davis-Poynter, Nicholas; Nguyen, Chau T. H.; Peters, Amelia A.; Monteith, Gregory R.; Strounina, Ekaterina; Popat, Amirali; Ross, Benjamin P.

doi:10.1039/c6nr03878f

Cited by 40 publications

(57 citation statements)

References 23 publications

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“…In accordance with our previous results, 17 unfunctionalized MSNs ( 1 ) did not reduce the formation of plaques of both HSV-1 and HSV-2 ( Figure S6 ). Therefore, the antiviral activity of nanoparticles observed in this study can be attributed to the action of the attached functional groups, with an aryl sulfonate ( 3 ) being optimal for antiviral activity amongst the series of tested compounds ( 3–7 ).…”

Section: Resultssupporting

confidence: 93%

“…Our previous study 17 and related studies 14 − 16 determined that aryl and alkyl sulfonate groups attached to nanoparticles have low toxicity to cells. Forming MSNs is also likely to reduce the toxicity relative to solid silica nanoparticles because of the decreased number of outer surface silanol groups.…”

Section: Resultsmentioning

confidence: 99%

“…This GAG mimetic was selected because it is the simplest form of aromatic sulfonate and MSNs functionalized with this group were previously demonstrated to inhibit the entry of HSV into susceptible cells. 17 The morphology of the nanoparticles was visualized by transmission electron microscopy (TEM), and their size was estimated using dynamic light scattering (DLS). The zeta potentials of all three analogues of MSN-phenyl-SO 3 ( 3 ) in aqueous suspension were less than −40 mV, which is likely to confer good colloidal stability because of the interparticle repulsion.…”

Section: Resultsmentioning

confidence: 99%

“… 14 − 16 In our recent study, an aryl sulfonate GAG mimetic-functionalized onto mesoporous silica nanoparticles (MSNs) was demonstrated to have low toxicity and inhibit the entry of HSV-1 and HSV-2 into susceptible cells, whereas unfunctionalized MSNs and the GAG mimetic alone were inactive. 17 However, an investigation into the structure–activity relationship (SAR) of functional groups attached to MSNs in the context of anti-HSV activity has not been explored. Hence, in this study, we modified MSNs with various functional groups related to the GAG structure and investigated their SARs against HSV-1 and HSV-2 infection of susceptible cells.…”

Section: Introductionmentioning

confidence: 99%

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Structure–Activity Relationships of GAG Mimetic-Functionalized Mesoporous Silica Nanoparticles and Evaluation of Acyclovir-Loaded Antiviral Nanoparticles with Dual Mechanisms of Action

Lee¹,

Nguyen²,

Strounina³

et al. 2018

ACS Omega

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Mesoporous silica nanoparticles (MSNs) are drug delivery agents that are able to incorporate drugs within their pores. Furthermore, MSNs can be functionalized by attachment of bioactive ligands on their surface to enhance their activity, and nanoparticles modified with glycosaminoglycan (GAG) mimetics inhibit the entry of herpes simplex virus (HSV) into cells. In this study, structure–activity relationships of GAGs attached to MSNs were investigated in relation to HSV-1 and HSV-2, and acyclovir was loaded into the pores of MSNs. The sulfonate group was demonstrated to be essential for antiviral activity, which was enhanced by incorporating a benzene group within the ligand. Loading acyclovir into GAG mimetic-functionalized MSNs reduced the viral infection, resulting in nanoparticles that simultaneously target two distinct viral pathways, namely, inhibition of viral entry and inhibition of DNA replication.

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Structure–Activity Relationships of GAG Mimetic-Functionalized Mesoporous Silica Nanoparticles and Evaluation of Acyclovir-Loaded Antiviral Nanoparticles with Dual Mechanisms of Action

Lee¹,

Nguyen²,

Strounina³

et al. 2018

ACS Omega

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“…[89] Viruses inactivation were carried out with different nanoparticles such as TiO 2 NPs, [84b] Au NPs, [88d] and Silica NPs. [90] The composite of various nanomaterials also exhibits promising results that may comprise the delivery of target species through nanocarrier. The nucleic acid-based antiviral drugs face problems of cell penetration.…”

Section: Case Studiesmentioning

confidence: 99%

COVID‐19: Emergence of Infectious Diseases, Nanotechnology Aspects, Challenges, and Future Perspectives

Gupta

Kumar

et al. 2020

ChemistrySelect

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Wuhan, a city of China, is the epicenter for the pandemic outbreak of coronavirus disease-2019 (COVID-19). It has become a severe public health challenge to the world and established a public health emergency of international worry. This infectious disease has pulled down the economy of almost all top developed nations. The coronaviruses (CoVs) known for various epidemics caused time to time. Infectious diseases such as severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS), followed by COVID-19, are all coronaviruses led outbreaks that scourged the history of mankind. CoVs evolved themselves to more infectious, transmissible, and more pandemic with time. To prevent the spread of the SARS-CoV-2, many countries have ordered the complete lockdown to combat the outbreak. This paper briefly discussed the historical background of CoVs and the evolution of human coronaviruses (HCoVs), the case studies and the development of their antiviral medications. The viral infection encountered with present-day challenges and futuristic approaches with the help of nanotechnology to minimize the spread of infectious viruses. The antiviral drugs and their clinical advances, along with herbal medicines for viral inhibition and immunity boosters, are described. Elaboration of tables related to CoVs for the compilation of the literature has been adopted for the better understanding.

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Nanotechnology‐Based Approach to Combat Pandemic COVID 19: A Review

Shukla

Tyagi

Bhandari

et al. 2021

Macromolecular Symposia

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The emergence of a novel Corona virus (COVID 19) originated on December 19 from China. The city of Wuhan, the capital city of Hubei province, China, is responsible for an outbreak of respiratory illness known as COVID 19 and it has been rapidly spread across the world claiming millions of lives. The sudden outbreak of novel Coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2 or 2019‐nCoV), is a big concern for their speedy mitigation using the predictable treatment and creating its approach around the world. Researchers and doctors are in search of rapid diagnosis kit, drugs, and viral‐resistant personal protective equipment (PPE) to clinical diagnosis, medication, and prevent the spread of COVID 19. A rational approach with adaptability and broad viewpoint to challenge the growing pain could be overcome by the application of appropriate technology. The nanotechnology‐based approach can significantly serve the purpose of the current pandemic situation of COVID 19. But same time implementation of innovative and creative nanotech approach, there is a decisive need for the full knowledge of SARS‐CoV‐2 pathogenesis. Moreover, to defeat COVID 19, particularly nanotech‐based system with their viral inhibitory properties to increase the effective nanotech approach is essential. In this scenario, this review aims to summarize the past, present, and future of nanotech‐based systems that can be used to treat COVID 19, highlighting Nano‐based compounds. Lastly, the potential application of the different category of Inorganic Nanomaterials/Inorganic organic conjugate /hybrid system and their practical applicability as suitable means for inspiring against COVID 19 has also been discussed.

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GAG mimetic functionalised solid and mesoporous silica nanoparticles as viral entry inhibitors of herpes simplex type 1 and type 2 viruses

Cited by 40 publications

References 23 publications

Structure–Activity Relationships of GAG Mimetic-Functionalized Mesoporous Silica Nanoparticles and Evaluation of Acyclovir-Loaded Antiviral Nanoparticles with Dual Mechanisms of Action

Structure–Activity Relationships of GAG Mimetic-Functionalized Mesoporous Silica Nanoparticles and Evaluation of Acyclovir-Loaded Antiviral Nanoparticles with Dual Mechanisms of Action

COVID‐19: Emergence of Infectious Diseases, Nanotechnology Aspects, Challenges, and Future Perspectives

Nanotechnology‐Based Approach to Combat Pandemic COVID 19: A Review

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