Gaetano Perusini: The Forgotten Neuroscientist Behind “Alzheimer’s” Disease

Pellegrini, F.; Rosso, Mattia; Chu, Duong

doi:10.1177/10738584211059466

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…As previously reported, various scholars identified a previously unidentified pathological entity before Charcot and Vulpian; in particular, Von Frerichs and Valentiner had given it a name (brain sclerosis-Hirnskleroses) and had described its important characteristics; the first diagnosis "in life" is also attributed to von Frerichs. However, as in other cases (e.g., Alzheimer and Perusini, regarding Alzheimer's disease- [102]; and Dax and Brocà, regarding the localization of lesions that cause aphasia- [103]), the scientific community generally attributed the identification of a pathological condition to those who inserted the individual aspects into a coherent framework or followed a conceptual or methodological setting established a priori.…”

Section: Discussionmentioning

confidence: 99%

Focus or Neglect on Cognitive Impairment Following the History of Multiple Sclerosis

Nocentini

2023

NeuroSci

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Cognitive disorders are now considered an integral part of the picture of multiple sclerosis. If we trace the history of the accounts of this disease, from the early descriptions by Jean-Martin Charcot, the first to provide systematic characteristics of multiple sclerosis, to present-day accounts, reports of cognitive disturbances have demonstrated an alternating trend. Cognitive disturbances were identified in the beginning, quite clearly for the times. Then, for a long time, they were considered infrequent or attributed to other factors. Finally, since the 1980s, cognitive disturbances have been the subject of increasingly in-depth studies, and are currently assumed to be a very important consequence of multiple sclerosis. In this work, the history of the description of cognitive disorders of multiple sclerosis will be retraced by analyzing the possible reasons for the differences in attention they have received over time. It emerged from the analysis that, as in the case of other pathologies, various factors have influenced how cognitive disorders have been taken into consideration. Some of these factors are inherent to the very nature of the cognitive impairments present in multiple sclerosis; others are linked to historical periods, or to the different ways of approaching the analysis of the phenomena caused by a disease. The reflections made on these topics should, among other things, increase our awareness of how scientific investigation is invariably placed in the historical context in which it is carried out.

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Section: Discussionmentioning

confidence: 99%

Focus or Neglect on Cognitive Impairment Following the History of Multiple Sclerosis

Nocentini

2023

NeuroSci

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“…Contrary to the common belief of those times, the two young doctors were convinced that the endemic goiter could not be explained by Morel's "degenerative theory" (also accepted by Kraepelin), but that it was linked to external "environmental" causes. This research was then considered fundamental, especially in light of the fact that, after a few years, the Italian Permanent Committee for the Fight against Cretinism adopted the guidelines for adding iodine to cooking salt [4].…”

Section: Editorialmentioning

confidence: 99%

“…In this latter field, Perusini left an indelible mark; his discoveries and annotations have stood the test of time until now. A more detailed description of his research on Alzheimer's disease can be found elsewhere [4]. However, it is important to mention a few here: (1) the concurrence of neurofibril changes with plaque formation; (2) observations on the nature and origin of senile plaques; (3) the understanding of the…”

Section: Editorialmentioning

confidence: 99%

The Short and Brave Life of Gaetano Perusini: A Tribute to His Role in Shaping Neuroscience

Pellegrini,

Mutali,

Zeppieri

2024

Cureus

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Gaetano Perusini was an early enigma in neuroscience. In an age where myths and religion still held tightly to medical knowledge, Dr. Perusini was a trailblazer, inventor, and decorated forerunner. Born in Udine, worshiped in Italy, educated across Europe, published all over the western hemisphere, and taken away from us during a time of worldwide strife, his story continues to fascinate us today. This is a short chronicle of the major events in his life that also celebrates his widely acclaimed influence on understanding Alzheimer's disease.

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Comprehensive Analysis of Long Non-Coding RNAs N4-Acetylcytidine in Alzheimer’s Disease Mice Model Using High-Throughput Sequencing

Chang

et al. 2022

JAD

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Background: N4-acetylcytidine (ac4C), an important posttranscriptional modification, is involved in various disease processes. Long noncoding RNAs (lncRNAs) regulate gene expression mainly through epigenetic modification, transcription, and posttranscriptional modification. Alzheimer’s disease (AD) is a neurodegenerative disease characterized by amyloidosis of the brain. However, the role of lncRNA ac4C modification in AD remains unclear. Objective: In this study, we investigated the association between ac4C modification and AD, and the underlying mechanisms of ac4C modification in AD. Methods: The male 9-month-old APP/PS1 double transgenic mice, age- and sex-matched wild type (WT) mice were used in this study. Then, ac4C-RIP-seq and RNA-seq were used to comprehensively analyze lncRNA ac4C modification in AD mice. The lncRNA-miRNA-mRNA regulatory networks using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses showed the regulatory relationships among these three lncRNAs and AD. Results: The results showed that there were 120 significantly different ac4C peaks located on 102 lncRNAs in AD, of which 55 were hyperacetylated and 47 were hypoacetylated. Simultaneously, 231 differentially expressed lncRNAs were identified, including 138 upregulated lncRNAs and 93 downregulated lncRNAs. Moreover, 3 lncRNAs, lncRNA Gm26508, lncRNA A430046D13Rik, and lncRNA 9530059O14Rik, showed significant changes in both the ac4C and RNA levels using conjoint analysis. Conclusion: The abundance of lncRNA ac4C modification is significantly different in AD and indicates that lncRNA ac4C is associated with the occurrence and development of AD, which could provide a basis for further exploration of the related regulatory mechanisms.

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Gaetano Perusini: The Forgotten Neuroscientist Behind “Alzheimer’s” Disease

Cited by 3 publications

References 7 publications

Focus or Neglect on Cognitive Impairment Following the History of Multiple Sclerosis

Focus or Neglect on Cognitive Impairment Following the History of Multiple Sclerosis

The Short and Brave Life of Gaetano Perusini: A Tribute to His Role in Shaping Neuroscience

Comprehensive Analysis of Long Non-Coding RNAs N4-Acetylcytidine in Alzheimer’s Disease Mice Model Using High-Throughput Sequencing

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