Gadolinium nanoparticles as diagnostic and therapeutic agents: Their delivery systems in magnetic resonance imaging and neutron capture therapy

Narmani, Asghar; Farhood, Bagher; Haghi‐Aminjan, Hamed; Mortezazadeh, Tohid; Aliasgharzadeh, Akbar; Mohseni, Mehran; Najafi, Masoud; Abbasi, Hadis

doi:10.1016/j.jddst.2018.01.011

Cited by 100 publications

(41 citation statements)

References 117 publications

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“…Although the introduction of novel technologies in radiotherapy instruments can help the management of radiation toxicity, the risk of damage to normal functions of organs remain. These novel technologies such as conformal radiotherapy, intensity-modulated radiotherapy (IMRT), image-guided radiotherapy (IGRT), stereotactic body radiotherapy (SBRT), drug delivery techniques and using heavy ion particles facilitate normal tissue sparing during the course of treatment [42,43]. Most of these techniques reduce the volume of irradiated organs, while heavy particle radiation reduces the dose to the normal tissue via an interesting property named Brag peak [44].…”

Section: Radiation Toxicity In Radiotherapymentioning

confidence: 99%

Radiation Protection and Mitigation by Natural Antioxidants and Flavonoids: Implications to Radiotherapy and Radiation Disasters

Yahyapour

Shabeeb

Cheki

et al. 2018

CMP

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Section: Radiation Toxicity In Radiotherapymentioning

confidence: 99%

Radiation Protection and Mitigation by Natural Antioxidants and Flavonoids: Implications to Radiotherapy and Radiation Disasters

Yahyapour

Shabeeb

Cheki

et al. 2018

CMP

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“…Nowadays nanoparticles (NPs) based technologies are developed in wide spectrum of prognosis, diagnosis, treatment, and prevention in medicine. These technologies are related with practical applications of different NPs including nano‐polymers, nanofibers, nanomembranes, nanosized chips, and nanomachines for protein, nucleic acid, peptide, and therapeutic agent delivery or their applications in nanosensors‐based detection (Petros & De Simone, ; Barratt, ; Narmani, Kamali, Amini, et al, ). The monodispersity, nanosize and shape, good biocompatibility, high capacity of surface modification and functionalization, great in vivo stability, excellent pharmacokinetic properties, and other specific aspects of NPs indicate great promise for their application in the treatment of cancers (Hawker & Wooley, ; Kesharwani, Jain, & Jain, ).…”

Section: Introductionmentioning

confidence: 99%

Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems

Narmani

Rezvani

Farhood

et al. 2019

Drug Development Research

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Conventional chemotherapeutic approaches in cancer therapy such as surgery, chemotherapy, and radiotherapy have several disadvantages due to their nontargeted distributions in the whole body. On the other hand, nanoparticles (NPs) based therapies are remarkably progressing to solve several limitations of conventional drug delivery systems (DDSs) including nonspecific biodistribution and targeting, poor water solubility, weak bioavailability and biodegradability, low pharmacokinetic properties, and so forth. The enhanced permeability and retention effect escape from Pglycoprotein trap in cancer cells as a passive targeting mechanism, and active targeting strategies are also other most important advantages of NPs in cancer diagnosis and therapy. Folic acid (FA) is one of the biologic molecules which has been targeted overexpressed-folic acid receptor (FR) on the surface of cancer cells. Therefore, conjugation of FA to NPs most easily enhances the FR-mediated targeting delivery of therapeutic agents. Here, the recent works in FA which have been decorated NPs-based DDSs are discussed and cancer therapy potency of these NPs in clinical trials are presented. K E Y W O R D Scancer diagnosis and therapy, folic acid, nanoparticles, nanotechnology, targeted drug delivery

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“…19 Among these nuclides, 157 Gd and 155 Gd have the largest cross-sections to capture with thermal neutron, as their cross-sections of neutron capture are 255,000 and 60,800 barns, respectively. 20 These are approximately 66 and 16 times greater than those of 10 B, respectively. Furthermore, it is notable that cross sections of neutron capture for the other isotopes are insignificantly small for dose calculations.…”

Section: Gdnctmentioning

confidence: 82%

Physical, dosimetric and clinical aspects and delivery systems in neutron capture therapy

Farhood

Samadian

Ghorbani

et al. 2018

Reports of Practical Oncology & Radiotherapy

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Neutron capture therapy (NCT) is a targeted radiotherapy for cancer treatment. In this method, neutrons with a spectra/specific energy (depending on the type of agent used for NCT) are captured with an agent that has a high cross-section with these neutrons. There are some agents that have been proposed in NCT including B,Gd and S. Among these agents, onlyB is used in clinical trials. Application of Gd is limited to in-vivo and in-vitro research. In addition,S has been applied in the field of Monte Carlo simulation. In BNCT, the only two delivery agents which are presently applied in clinical trials are BPA and BSH, but other delivery systems are being developed for more effective treatment in NCT. Neutron sources used in NCT are fission reactors, accelerators, and Cf. Among these, fission reactors have the most application in NCT. So far, BNCT has been applied to treat various cancers including glioblastoma multiforme, malignant glioma, malignant meningioma, liver, head and neck, lung, colon, melanoma, thyroid, hepatic, gastrointestinal cancer, and extra-mammary Paget's disease. This paper aims to review physical, dosimetric and clinical aspects as well as delivery systems in NCT for various agents.

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Gadolinium nanoparticles as diagnostic and therapeutic agents: Their delivery systems in magnetic resonance imaging and neutron capture therapy

Cited by 100 publications

References 117 publications

Radiation Protection and Mitigation by Natural Antioxidants and Flavonoids: Implications to Radiotherapy and Radiation Disasters

Radiation Protection and Mitigation by Natural Antioxidants and Flavonoids: Implications to Radiotherapy and Radiation Disasters

Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems

Physical, dosimetric and clinical aspects and delivery systems in neutron capture therapy

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