Gadolinium(III) texaphyrin: a novel MRI contrast agent

Abstract

Magnetic resonance imaging (MRI) is now well established as an important tool for the diagnosis and evaluation of a variety of diseases.* 1 2345Nonetheless, considerable effort continues to be devoted to the development and study of potential MRI contrast

Gadolinium(III) texaphyrin: a tumor selective radiation sensitizer that is detectable by MRI.

“…We have developed a new radiation sensitizer [i.e., gadolinium(III) texaphyrin (Gd-tex2+)] that, due to its novel mechanism of action, and tumor-selective localizing ability, meets these criteria. An additional benefit of this radiation sensitizer that has not been available with previous sensitizers is that it is detectable in vivo by magnetic resonance imaging (MRI) methods (24,25). Monitoring the selective accumulation of gadolinium(III) texaphyrin in neoplasms by MRI enables the possibility of treatment planning and subsequent monitoring of the response I 2 of cancers to the radiation therapy.…”

Synthesis ,Characterisation And Anti Cancerus Studies of Schiff Base Complexes of Co(II),Cu(II) And Ni(II) Using DFMPM And L-Histidine

“…The antimicrobial study showed that Ni(II) have more antibacterial activity than other two complexes. Anti cancerous study shows that when of [NiL(NO 3 …”

“…The presence of H -C = N-group is indicated by the singlet at δ = 7.023ppm. The multiplet at δ 6.537 ppm -δ = 6.639 ppm and δ = 5.168 ppm -δ = 5.691 ppm were due to the olifinic protons of the side chain and -O-CH 2 -group of the ligand respectively [21][22] . Figure 13), the presence of H -C = N-group is indicated by the singlet at δ = 7.250 ppm it is due to the olifinic protons of the side chain and -O-CH 2 -group.…”

“…A variety of Schiff's base and its complexes have been studied extensively [1] . Cardanol is the main component obtained by vaccum distillation of roasted cashew nut shell liquid (CNSL) and was used for the preparation of bioactive transition Schiff base metal complexs using standard methods [2][3] . The ligand and complexes were characterised by UV-visible, FTIR, 1 HNMR, elemental analysis, melting point, conductivity, metal ion intake, anti bacterial, anti fungal, anti cancer, DNA cleavage, larvacidal and anti inflammatory activity were studied .…”

Synthesis and Characterization of UO2(VI), Th(IV), ZrO(IV) and VO(IV) Complexes with Schiff-Base Octaazamacrocyclic Ligands

“…Mixed donor Schiff bases have been used extensively in catalysis. The design and synthesis of macrocyclic lanthanide complexes is currently attracting considerable attention since they can be used as supramolecular devices and sensors, 1,2 contrast agents in magnetic resonance imaging, [3][4][5] potential radiopharmaceuticals, 6 as possible bioinorganic models for the active sites in metallobiomolecules, 7,8 as synthetic nucleases for in vivo application. 9 The chemistry of macrocyclic complexes has attracted the interest of both inorganic and bioinorganic chemists in recent years.…”