Gadolinium-DTPA (Magnevist^®) als Kontrastmittel für die arterielle DSA

Abstract

16 DSA investigations using intra-arterial Gd-DTPA were performed on 12 patients. The contrast medium was administered either as a 0.5 molar gadolinium solution (commercially available) or diluted with distilled water to a 0.2-0.4 molar gadolinium solution. The injection was made either by pressure injector or by hand. The aortic arch, abdominal aorta and pelvic and lower limb arteries were examined. 14 of the 16 procedures were diagnostically adequate, but compared with iodinated contrast materials, contrast was less marked. There were no cardiovascular, neurological or allergic side effects. Three patients suffered a feeling of heat and one patient had mild pain during the injection. Even large volumes rapidly injected (up to 20 ml/s of the commercially available solution) were well tolerated. DSA with intra-arterial Gd-DTPA seems to be a suitable alternative for vascular imaging if iodine-containing contrast materials are contraindicated.

Feasibility of MR-guided Angioplasty of Femoral Artery Stenoses Using Real-time Imaging and Intraarterial Contrast-enhanced MR Angiography

“…Until now, no experience existed with intraarterial MRA in humans. Some studies deal with the intraarterial application of gadolinium-complex in DSA [9,10], with allergic reactions to iodide contrast agents, renal insufficiency, and hyperthyroidism the reasons for selecting a gadolinium complex. The osmolality of gadodiamide is 780 mmol/kg.…”

Renal Insufficiency: Usefulness of Gadodiamide-enhanced Renal Angiography to Supplement CO2-enhanced Renal Angiography for Diagnosis and Percutaneous Treatment

“…Several authors (23)(24)(25)(60)(61)(62) have described the use of gadolinium-based contrast agents in angiographic studies of the abdominal aorta and mesenteric, pelvic, peripheral, and renal arteries.…”

“…There is no reported animal experience with intraarterial delivery of gadolinium-based contrast agents. Two studies with 15 and 12 patients and several case reports (23)(24)(25)(60)(61)(62) have been published in which intraarterial gadolinium-based contrast agents were used for digital subtraction angiography. At the time this article was written, we had used gadolinium-based contrast agents distributed in arteries throughout the body (with the exception of the cerebral vessels and heart) in more than 100 patients, without evidence of vascular thrombosis.…”

X-Ray Contrast Media

“…Initial clinical applications suggest the suitability of chelates for X-ray techniques but safety issues remain to be solved [108,109]. The images or other third party material in this chapter are included in the chapter's Creative Commons license, unless indicated otherwise in a credit line to the material.…”